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Escherichia coli
Escherichia coli is a normal inhabitant of the intestines of all vertebrate animals, including humans. Normally E. coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesizing appreciable amounts of vitamins. However, enteropathogenic and enterohemmorrhagic E. coli strains are important causal agents of infectious diarrhea, particularly amongst pediatric populations. Enterohemmorrhagic E. coli (EHEC) is an important zoonotic pathogen of humans, causing severe diarrhea (hemorrhagic colitis) and sometimes hemolytic-uremic syndrome (HUS). Unfortunately, antibiotics increase the risk of HUS, and there are no current therapies for EHEC infections in human other than general supportive measures. EHEC can be transmitted by food and water. EHEC serotype O157:H7 is the leading cause of HUS in North America and Europe. Infection by E. coli O157:H7 is most commonly caused by the consumption of undercooked, contaminated ground beef or beef products, but can also be caused by contaminated drinking or recreational water, raw milk, and person to person contact. The infection mechanisms by which EHEC causes hemorrhagic colitis and HUS are not fully understood.
PHIDIAS includes a list of programs for analysis of
Escherichia coli
and the interactions between host and
Escherichia coli:
- General Information: General information about Escherichia coli and E. coli O157:H7 infection/Diarrhea is described in Phinfo. Please click here for advanced topic search.
- Escherichia coli GBrowse: Escherichia coli genome browser. This program allows searching, comparison, and visualization of
Escherichia coli genomes and individual DNA/protein/RNA sequences. It is part of PGBrowser and also allows comparison with other genome sequences.
- Gene Query: This program searches
Escherichia coli and host genes. This is part of Phigen that also be used to compare with other pathogen genes.
- Protein Domains in Escherichia coli: This program searches
Escherichia coli -specific protein domains. As an integrated part of Pacodom, this program can also be used to search and compare protein domains of other pathogens
- Host-
Escherichia coli
Interaction Network: this program analyze networks involving the interactions between Escherichia coli and hosts. It is part of Phinet that also targets for many other pathogens.
- Escherichia coli-specific Gene Expression: Phix
- Interaction between Escherichia coli and Macrophages: MacroPath
Other Relevant Projects Developed by He Group:
Additional Web Links:
- EcoCyc:
EcoCyc is a scientific database for Escherichia coli K-12 strain MG1655. EcoCyc performs literature-based curation of the entire genome, and of its transcriptional regulation, transporters, and metabolic pathways.
- RegulonDB:
RegulonDB offers curated knowledge of the transcriptional regulatory network of Escherichia coli K12, currently the best-known electronically encoded database of the genetic regulatory network of any free-living organism.
- NCBI Entrez Genome Project:
NCBI Entrez Portal to different E. coli genome sequence projects.
- GenProtENZYME: E. coli genome and proteome database:
GenProtEC is dedicated to the functions encoded by the Escherichia coli K-12 (strain MG1655) genome defined in the GenBank Accession No. NC_000913.2 deposit.
- IECA: International E. coli Alliance E. coli Database Portal:
Portal to online E. coli resources.
- E.coli at CDC:
General information about E. coli.
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