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Found 25 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
3949 bhuR Bordetella pertussis Tohama I 2664030 33591576 BP0347 BX640412 NP_879220 outer membrane heme receptor Virulence factor MUTATION: attenuated in mice (Brickman et al., 2006). 16495546
3950 prn Bordetella pertussis Tohama I 2664290 33592195 BP1054 BX640414 NP_879839 pertactin precursor Virulence factor MUTATION: mutant was 30% to 40% less efficient at adhering to CHO cells and to human HeLa cells compared to parent (Leininger et al., 1991). 1988935
3951 cyaC Bordetella pertussis Tohama I 2664491 33591933 BP0758 BX640413 NP_879577 cyclolysin-activating lysine-acyltransferase Virulence factor MUTATION: cyaC mutant had toxin activities less than 1% of the wild type (Barry et al., 1991). 1987161
3952 cyaA Bordetella pertussis Tohama I 2664492 33591934 BP0760 BX640413 NP_879578 bifunctional hemolysin-adenylate cyclase precursor Virulence factor MUTATION: mutant strain was unable to multiply as fast and is avirulent in murine respiratory models (Khelef et al., 1992). 1614333
3953 brkB Bordetella pertussis Tohama I 2664891 33594368 BP3493 BX640421 NP_882012 serum resistance protein Virulence factor MUTATION: attenuated in infant mice (Smith et al., 2001). 11348687
3954 brkA Bordetella pertussis Tohama I 2664892 33594369 BP3494 BX640421 NP_882013 serum resistance protein Virulence factor MUTATION: attenuated in infant mice (Smith et al., 2001). 11348687
3955 tonB Bordetella pertussis Tohama I 2664931 33594402 BP3531 BX640421 NP_882046 siderophore-mediated iron transport protein Virulence factor MUTATION: tonB exb double mutant is attenuated in mice (Pradel et al., 2000). 10722583
3956 exbB Bordetella pertussis Tohama I 2664932 33594403 BP3532 BX640421 NP_882047 MotA/TolQ/ExbB proton channel family protein Virulence factor MUTATION: tonB exbB double mutant is attenuated in mice (Pradel et al., 2000). 10722583
3957 ptxA Bordetella pertussis 2665068 33594638 BP3783 NP_882282.1 toxin subunit 1 Virulence factor MUTATION: deletion mutant displayed a significant defect in respiratory tract colonization in mice (Carbonetti et al., 2004). 15155640
3958 ptxB Bordetella pertussis 2665069 33594639 BP3784 NP_882283.1 toxin subunit 2 Virulence factor MUTATION: deletion mutant displayed a significant defect in respiratory tract colonization in mice (Carbonetti et al., 2004). 15155640
3959 BP0123 Bordetella pertussis Tohama I 2665353 33591381 BP0123 BX640411 NP_879025 putative cAMP phosphodiesterase Virulence factor MUTATION: deletion mutant avirulent in the infant mouse model (Weiss and Hewlett, 1986). 2877614
3960 fim3 Bordetella pertussis Tohama I 2665596 33592658 BP1568 BX640415 NP_880302 serotype 3 fimbrial subunit precursor Virulence factor MUTATION: deletion mutant showed significantly reduced ability to colonize in the trachea of a mouse respiratory infection model (Mooi et al., 1992). 1350044
3961 BP3072 Bordetella pertussis Tohama I 2666331 33593999 BP3072 BX640420 NP_881643 lipid A biosynthesis lauroyl acyltransferase Virulence factor MUTATION: lpxL1 deficient mutant displayed defect in infection of human macrophages (Geurtsen et al., 2007). 17967899
3962 tcfA Bordetella pertussis Tohama I 2666888 33592330 BP1201 BX640414 NP_879974 tracheal colonization factor precursor Virulence factor MUTATION: TcfA mutation reduced bacteria by 10 fold compared to parent strain (Finn and Stevens, 1995). 7476158
3963 dnt Bordetella pertussis Tohama I 2666936 33594321 BP3439 BX640421 NP_881965 dermonecrotic toxin Virulence factor MUTATION: deletion mutant attenuated in mice (Feunou et al., 2008). 18762220
3964 bvgR Bordetella pertussis Tohama I 2667056 33592924 BP1876 AF071567 NP_880568 regulatory protein BvgR Virulence factor MUTATION: mutant showed reduced colonization in mice compared to wild-type (Smith et al., 2001). 11348687
3965 bvgS Bordetella pertussis Tohama I 2667057 33592925 BP1877 BX640416 NP_880569 virulence sensor protein Virulence factor MUTATION: mutant displayed reduced virulence, and lost ability to express some Bvg+-phase factors (Cotter and Miller, 1997). 9194696
3966 bvgA Bordetella pertussis Tohama I 2667058 33592926 BP1878 BX640416 NP_880570 virulence factors transcription regulator Virulence factor MUTATION: mutant strain showed growth inhibition and reduced colonization (Stibitz, 1998). 9573202
3967 fhaB Bordetella pertussis 2667059 33592927 BP1879 NP_880571.1 filamentous hemagglutinin/adhesin Virulence factor MUTATION: FhaB mutation abolished bacterial adhesion to Chinese Hamster Ovary cells (Aricò et al., 1993). 8415678
3968 bscN Bordetella pertussis Tohama I 2667132 33593244 BP2245 BX640417 NP_880888 type III secretion system ATPase Virulence factor MUTATION: deletion mutant showed a decrease in cytotoxicity and secretion of proteins in vitro as well as reduced colonization in the trachea of a rat infection model (Yuk et al., 1998). 9663681
3969 fimD Bordetella pertussis Tohama I 2667435 33592930 BP1883 BX640416 NP_880574 fimbrial adhesin Virulence factor MUTATION: FimD mutant strain showed reduced colonization in the lungs and trachea of mice (Smith et al., 2001). 11348687
3970 fhaC Bordetella pertussis Tohama I 2667436 33592931 BP1884 BX640416 NP_880575 hemolysin activator-like protein Virulence factor MUTATION: mutation strongly reduced binding to CHO cells (Aricò et al., 1993). 8415678
3971 fauA Bordetella pertussis Tohama I 2667469 33593446 BP2463 BX640418 NP_881090 ferric alcaligin siderophore receptor Virulence factor MUTATION: fauA mutant is attenuated in mice (Brickman and Armstrong, 2007). 17724074
4950 aroA Bordetella pertussis 144037 Virulence factor MUTATION: An aroA mutant is highly attenuated in mice (Roberts et al., 1990). 2407655
4951 fla