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Found 238 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
759 spoT from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1145050 22124023 y0103 NP_667446.1 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
760 purH from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1145449 22124417 y0502 NP_667840.1 AICAR formyltransferase; IMP cyclohydrolase Virulence factor MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004). 14742535
761 hfq from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1145577 22124544 y0630 NP_667967.1 RNA-binding protein Hfq Virulence factor MUTATION: hfq mutant is highly attenuated in mice after subcutaneous or intravenous injection and has attenuated survival in macrophages (Geng et al., 2009). 19593436
762 greA from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1145626 22124593 y0679 NP_668016.1 transcription elongation factor GreA Virulence factor MUTATION: greA mutants are attenuated in mice (Flashner et al., 2004). 14742535
763 relA from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1145758 22124724 y0811 NP_668147.1 GDP/GTP pyrophosphokinase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
764 pcm from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1145779 22124743 y0832 NP_668166.1 protein-L-isoaspartate O-methyltransferase Virulence factor MUTATION: pcm mutant is attenuated in mice (Flashner et al., 2004). 14742535
765 nlpD from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1145780 22124744 y0833 NP_668167.1 predicted outer membrane lipoprotein Virulence factor MUTATION: nlpD mutant is attenuated in mice (Tidhar et al., 2009). 19759820
766 purK from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146049 22125006 y1102 NP_668429.1 AIR carboxylase, CO(2)-fixing subunit Virulence factor MUTATION: purK mutant is attenuated in mice (Flashner et al., 2004). 14742535
767 y1136 Yersinia pestis KIM 10 1146083 22125040 y1136 AE009952 NP_668463 hypothetical protein Virulence factor MUTATION: y1136 mutant is attenuated in mice (Flashner et al., 2004). 14742535
768 pgm from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146205 22125158 y1258 NP_668581.1 phosphoglucomutase Virulence factor MUTATION: pgm mutant of Y. pestis is attenuated in mice (Welkos et al., 2002). 12009274
769 ompX from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146271 22125223 y1324 NP_668646.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
770 y1436 Yersinia pestis KIM 10 1146382 22125333 y1436 AE009952 NP_668756 enzyme Virulence factor MUTATION: y1436 mutant is attenuated in mice (Flashner et al., 2004). 14742535
771 y1537 Yersinia pestis KIM 10 1146484 22125434 y1537 AE009952 NP_668857 hypothetical protein Virulence factor MUTATION: y1537 mutant is attenuated in mice (Flashner et al., 2004). 14742535
772 ompX from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146629 22125577 y1682 NP_669000.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
773 y1718 Yersinia pestis KIM 10 1146665 22125612 y1718 AE009952 NP_669035 hypothetical protein Virulence factor MUTATION: y1718 mutant is attenuated in mice (Flashner et al., 2004). 14742535
774 phoP from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146741 22125688 y1794 NP_669111.1 DNA-binding response regulator in two-component regulatory system with PhoQ Virulence factor MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain (Oyston et al., 2000). 10816493
775 mgtC from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146767 22125713 y1820 NP_669136.1 transport ATPase Virulence factor MUTATION: mgtC mutants are defective in early intracellular survival in macrophages compared to wild type Y. pestis (Grabenstein et al., 2006). 16790745
776 yfeB from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146843 22125789 y1896 NP_669212.1 ATP-binding protein for iron and manganese ABC transporter Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
777 yfeA from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146844 22125790 y1897 NP_669213.1 periplasmic-binding protein for iron and manganese ABC transporter Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
778 ompX from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1146981 22125926 y2034 NP_669349.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
779 msbB from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1147194 22126133 y2247 NP_669556.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Virulence factor MUTATION: lpxM (msbB) mutant is avirulent in mice and guinea pigs (Feodorova et al., 2007). 17913308
780 y2285 Yersinia pestis KIM 10 1147232 22126170 y2285 AE009952 NP_669593 putative sulfate transporter YchM Virulence factor MUTATION: YchM mutant is attenuated in mice (Flashner et al., 2004). 14742535
781 y2316 Yersinia pestis KIM 10 1147263 22126201 y2316 AE009952 NP_669624 hypothetical protein Virulence factor MUTATION: y2316 mutant is attenuated in mice (Flashner et al., 2004). 14742535
782 ybtP from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1147344 22126281 y2397 NP_669704.1 permease and ATP-binding protein of yersiniabactin-iron ABC transporter Virulence factor MUTATION: ybtP mutant is avirulent in mouse bubonic plague model (Fetherston et al., 1999). 10231486
783 irp2 from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1147346 22126283 y2399 NP_669706.1 HMWP2 nonribosomal peptide synthetase Virulence factor MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media (Fetherston et al., 1995). 7896707
784 psn Yersinia pestis KIM 10 1147351 22126288 y2404 NP_669711.1 pesticin/yersiniabactin outer membrane receptor Virulence factor MUTATION: psn mutant is unable to grow on iron-deficient media at 37 degrees C (Fetherston et al., 1995). 7896707
785 y2785 Yersinia pestis KIM 10 1147732 22126663 y2785 AE009952 NP_670086 hypothetical protein Virulence factor MUTATION: yadBC mutant is attenuated in mice and is less invasive of HeLa cells than the wild-type (Forman et al., 2008). 18025093
786 y2786 Yersinia pestis KIM 10 1147733 22126664 y2786 AE009952 NP_670087 hypothetical protein Virulence factor MUTATION: yadBC mutant is attenuated in mice and is less invasive of HeLa cells than the wild-type (Forman et al., 2008). 18025093
787 psaA from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1147829 22126759 y2882 NP_670182.1 pH 6 Antigen fimbrial subunit Virulence factor MUTATION: psaA mutants have a 100-fold reduced 50% lethal dose in mice (Lindler et al., 1990). 2164509
788 psaE from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1147831 22126761 y2884 NP_670184.1 regulator Virulence factor MUTATION: psaE mutants are attenuated in mice (Lindler et al., 1990). 2164509
789 y3010 Yersinia pestis KIM 10 1147957 22126887 y3010 AE009952 NP_670310 hypothetical protein Virulence factor MUTATION: y3010 mutant is attenuated in mice (Flashner et al., 2004). 14742535
790 smpB from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1148026 22126955 y3079 NP_670378.1 SsrA-binding protein Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
791 dnaE from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1148067 22126996 y3120 NP_670419.1 DNA polymerase III subunit alpha Virulence factor MUTATION: dnaE mutant is attenuated in mice (Flashner et al., 2004). 14742535
792 y3395 Yersinia pestis KIM 10 1148342 22127271 y3395 AE009952 NP_670694 hypothetical protein Virulence factor MUTATION: y3395 mutant is attenuated in mice (Flashner et al., 2004). 14742535
793 thrL Yersinia pestis KIM 10 1148666 22127593 y3719 AE009952 NP_671016 thr operon leader peptide Virulence factor MUTATION: y3719 mutant is attenuated in mice (Flashner et al., 2004). 14742535
794 yapE from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1148792 22127716 y3845 NP_671139.1 autotransporter protein Virulence factor MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model (Lawrenz et al., 2009). 18936182
795 y3857 Yersinia pestis KIM 10 1148804 22127728 y3857 AE009952 NP_671151 metalloprotease Virulence factor MUTATION: y3857 mutant is attenuated in mice (Flashner et al., 2004). 14742535
796 dam from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1148884 22127807 y3937 NP_671230.1 DNA adenine methylase Virulence factor MUTATION: dam mutant is attenuated in mice (Robinson et al., 2005). 16188402
797 crp from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1148903 22127826 y3956 NP_671249.1 cAMP-regulatory protein Virulence factor MUTATION: crp mutant is attenuated in mice (Sun et al., 2010). 20086087
798 caf1M from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149242 39980777 Y1098 NP_857879.2 F1 capsule Virulence factor MUTATION: caf1M mutants are attenuated in mice (Welkos et al., 2004). 14711524
1117 pla from Yersinia pestis CO92 Yersinia pestis CO92 1172643 16082686 YPPCP1.07 NP_395233.1 outer membrane protease Virulence factor MUTATION: pla mutant is attenuated in mice (Sodeinde et al., 1992). 1439793
1118 yopE from Yersinia pestis CO92 Yersinia pestis CO92 1172651 16082697 YPCD1.06 NP_395143.1 putative outer membrane virulence protein Virulence factor MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice (Rosqvist et al., 1990). 2191183
1119 yopQ from Yersinia pestis CO92 Yersinia pestis CO92 1172664 16082708 YPCD1.19c NP_395154.1 Yop targeting protein Virulence factor MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days (Straley and Bowmer, 1986). 3002984
1120 yopT from Yersinia pestis CO92 Yersinia pestis CO92 1172665 16082709 YPCD1.20 NP_395155.1 Yop targeted effector Virulence factor TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998). 9723929
1121 yopM from Yersinia pestis CO92 Yersinia pestis CO92 1172671 16082715 YPCD1.26c NP_395161.1 secreted effector protein Virulence factor MUTATION: yopM mutant is attenuated in mice compared to the wild type (Leung et al., 1990). 2401564
1122 yopD from Yersinia pestis CO92 Yersinia pestis CO92 1172673 16082716 YPCD1.28c NP_395162.1 secreted effector protein Virulence factor MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991). 1937815
1123 yopB from Yersinia pestis CO92 Yersinia pestis CO92 1172674 16082717 YPCD1.29c NP_395163.1 secreted effector protein Virulence factor MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (Håkansson et al., 1996). 8918459
1124 sycD from Yersinia pestis CO92 Yersinia pestis CO92 1172675 16082718 YPCD1.30c NP_395164.1 secretion chaperone Virulence factor MUTATION: lcrH mutant is avirulent in mice (Price and Straley, 1989). 2707857
1125 lcrV from Yersinia pestis CO92 Yersinia pestis CO92 1172676 16082719 YPCD1.31c NP_395165.1 secreted effector protein Virulence factor MUTATION: lcrV mutants are avirulent in mice (Skrzypek and Straley, 1995). 7730287
1126 virF from Yersinia pestis CO92 Yersinia pestis CO92 1172694 16082737 YPCD1.49 NP_395183.1 transcriptional regulator Virulence factor MUTATION: lcrF mutant is attenuated in mice (Flashner et al., 2004). 14742535
1127 yopH from Yersinia pestis CO92 Yersinia pestis CO92 1172712 16082755 YPCD1.67c NP_395201.1 putative secreted protein-tyrosine phosphatase Virulence factor MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996). 8809758
1128 ypkA from Yersinia pestis CO92 Yersinia pestis CO92 1172717 16082760 YPCD1.72c NP_395206.1 secreted protein kinase Virulence factor MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice (Galyov et al., 1993). 8441468
1129 caf1M from Yersinia pestis CO92 Yersinia pestis CO92 1172837 16082874 YPMT1.82 NP_395428.1 putative F1 chaperone protein Virulence factor MUTATION: caf1M mutants are attenuated in mice (Welkos et al., 2004). 14711524
1130 caf1A from Yersinia pestis CO92 Yersinia pestis CO92 1172838 16082875 YPMT1.83 NP_395429.1 putative F1 capsule anchoring protein Virulence factor MUTATION: caf1A mutants are attenuated in mice (Welkos et al., 2004). 14711524
1131 spoT from Yersinia pestis CO92 Yersinia pestis CO92 1172888 16120391 YPO0038 NP_403704.1 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
1132 dam from Yersinia pestis CO92 Yersinia pestis CO92 1173000 16120497 YPO0154 NP_403810.1 DNA adenine methylase Virulence factor MUTATION: dam mutant is attenuated in mice (Robinson et al., 2005). 16188402
1133 crp from Yersinia pestis CO92 Yersinia pestis CO92 1173020 16120516 YPO0175 NP_403829.1 cAMP-regulatory protein Virulence factor MUTATION: crp mutant is attenuated in mice (Sun et al., 2010). 20086087
1134 hfq from Yersinia pestis CO92 Yersinia pestis CO92 1173219 16120708 YPO0373 NP_404021.1 RNA-binding protein Hfq Virulence factor MUTATION: hfq mutant is highly attenuated in mice after subcutaneous or intravenous injection and has attenuated survival in macrophages (Geng et al., 2009). 19593436
1135 arcA Yersinia pestis CO92 1173302 218927655 YPO0458 AL590842 YP_002345530 two-component response regulator Virulence factor MUTATION: arcA mutant is attenuated in mice (Flashner et al., 2004). 14742535
1136 YPO1003 Yersinia pestis CO92 1173841 218928173 YPO1003 AL590842 YP_002346048 hypothetical protein Virulence factor MUTATION: YPO1003 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1137 dnaE from Yersinia pestis CO92 Yersinia pestis CO92 1173899 16121359 YPO1059 NP_404672.1 DNA polymerase III subunit alpha Virulence factor MUTATION: dnaE mutant is attenuated in mice (Flashner et al., 2004). 14742535
1138 ssrA from Yersinia pestis CO92 Yersinia pestis CO92 1173948 0 YPOs04 - misc_RNA Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1139 smpB from Yersinia pestis CO92 Yersinia pestis CO92 1173949 16121401 YPO1101 NP_404714.1 SsrA-binding protein Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1140 YPO1179 Yersinia pestis CO92 1174028 218928342 YPO1179 AL590842 YP_002346217 hypothetical protein Virulence factor MUTATION: YPO1179 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1141 psaE from Yersinia pestis CO92 Yersinia pestis CO92 1174143 16121583 YPO1301 NP_404896.1 putative regulatory protein Virulence factor MUTATION: psaE mutants are attenuated in mice (Lindler et al., 1990). 2164509
1142 psaA from Yersinia pestis CO92 Yersinia pestis CO92 1174145 16121585 YPO1303 NP_404898.1 pH 6 antigen precursor (antigen 4) (adhesin) Virulence factor MUTATION: psaA mutants have a 100-fold reduced 50% lethal dose in mice (Lindler et al., 1990). 2164509
1143 YPO1387 Yersinia pestis CO92 1174228 218928535 YPO1387 AL590842 YP_002346410 hypothetical protein Virulence factor MUTATION: yadBC mutant (yadB is YPO1387) is attenuated in mice and is less invasive to HeLa cells than the wildtype (Forman et al., 2008). 18025093
1144 YPO1388 Yersinia pestis CO92 1174229 218928536 YPO1388 AL590842 YP_002346411 hypothetical protein Virulence factor MUTATION: yadBC (yadC is YPO1388) mutant is attenuated in mice and is less invasive of HeLa cells than the wild-type (Forman et al., 2008). 18025093
1145 phoP from Yersinia pestis CO92 Yersinia pestis CO92 1174473 16121902 YPO1634 NP_405215.1 DNA-binding response regulator in two-component regulatory system with PhoQ Virulence factor MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain (Oyston et al., 2000). 10816493
1146 mgtC from Yersinia pestis CO92 Yersinia pestis CO92 1174499 16121925 YPO1660 NP_405238.1 Mg(2+) transport ATPase protein C Virulence factor MUTATION: mgtC mutants are defective in early intracellular survival in macrophages compared to wild type Y. pestis (Grabenstein et al., 2006). 16790745
1147 ail Yersinia pestis CO92 1174696 218928979 YPO1860 AL590842 YP_002346854 attachment invasion locus protein Virulence factor MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice (Bartra et al., 2008). 18025094
1148 fyuA from Yersinia pestis CO92 Yersinia pestis CO92 1174745 16122154 YPO1906 NP_405467.1 pesticin/yersiniabactin receptor protein Virulence factor MUTATION: psn mutant is unable to grow on iron-deficient media at 37 degrees C (Fetherston et al., 1995). 7896707
1149 irp2 from Yersinia pestis CO92 Yersinia pestis CO92 1174750 16122159 YPO1911 NP_405472.1 yersiniabactin biosynthetic protein Virulence factor MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media (Fetherston et al., 1995). 7896707
1150 ybtP from Yersinia pestis CO92 Yersinia pestis CO92 1174752 16122161 YPO1913 NP_405474.1 lipoprotein inner membrane ABC-transporter Virulence factor MUTATION: ybtP mutant is avirulent in mouse bubonic plague model (Fetherston et al., 1999). 10231486
1151 YPO1994 Yersinia pestis CO92 1174831 218929104 YPO1994 AL590842 YP_002346979 hypothetical protein Virulence factor MUTATION: YPO1994 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1152 YPO2027 Yersinia pestis CO92 1174861 0 YPO2027 - pseudo Virulence factor MUTATION: YPO2027 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1153 msbB from Yersinia pestis CO92 Yersinia pestis CO92 1174901 16122302 YPO2063 NP_405615.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Virulence factor MUTATION: lpxM (msbB) mutant is avirulent in mice and guinea pigs (Feodorova et al., 2007). 17913308
1154 ail from Yersinia pestis CO92 Yersinia pestis CO92 1175024 16122420 YPO2190 NP_405733.1 attachment invasion locus protein precursor Virulence factor MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice (Bartra et al., 2008). 18025094
1155 slyA Yersinia pestis CO92 1175206 16122597 YPO2374 NP_405910.1 transcriptional regulator SlyA Virulence factor MUTATION: slyA (rovA) mutant is attenuated in mice (Cathelyn et al., 2006). 16938880
1156 lpp from Yersinia pestis CO92 Yersinia pestis CO92 1175228 16122617 YPO2394 NP_405930.1 major outer membrane lipoprotein Virulence factor MUTATION: lpp deletion mutant is attenuated in mice (Liu et al., 2010). 19737605
1157 yfeA from Yersinia pestis CO92 Yersinia pestis CO92 1175273 16122660 YPO2439 NP_405973.1 periplasmic-binding protein Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
1158 yfeB from Yersinia pestis CO92 Yersinia pestis CO92 1175274 16122661 YPO2440 NP_405974.1 ATP-binding transport protein Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
1159 YPO2471 Yersinia pestis CO92 1175305 218929560 YPO2471 AL590842 YP_002347435 hypothetical protein Virulence factor MUTATION: YPO2471 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1160 ompX from Yersinia pestis CO92 Yersinia pestis CO92 1175340 16122727 YPO2506 NP_406040.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
1161 pgm from Yersinia pestis CO92 Yersinia pestis CO92 1175516 16122891 YPO2686 NP_406204.1 phosphoglucomutase Virulence factor MUTATION: pgm mutant of Y. pestis is attenuated in mice (Welkos et al., 2002). 12009274
1162 YPO2793 Yersinia pestis CO92 1175620 218929860 YPO2793 AL590842 YP_002347735 hypothetical protein Virulence factor MUTATION: YPO2793 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1163 guaA Yersinia pestis CO92 1175694 16123062 YPO2870 NP_406375.1 bifunctional GMP synthase/glutamine amidotransferase protein Virulence factor MUTATION: guaBA operon mutant is highly attenuated in mice (Oyston et al., 2010). 20096773
1164 guaB Yersinia pestis CO92 1175695 16123063 YPO2871 NP_406376.1 inositol-5-monophosphate dehydrogenase Virulence factor MUTATION: guaBA operon mutant is highly attenuated in mice (Oyston et al., 2010). 20096773
1165 ail from Yersinia pestis CO92 Yersinia pestis CO92 1175729 16123096 YPO2905 NP_406409.1 attachment invasion locus protein Virulence factor MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice (Bartra et al., 2008). 18025094
1166 YPO2947 Yersinia pestis CO92 1175766 16123130 YPO2947 NP_406443.1 hypothetical protein Virulence factor MUTATION: YPO2947 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1167 YPO3045 Yersinia pestis CO92 1175866 16123222 YPO3045 NP_406535.1 hypothetical protein Virulence factor MUTATION: YP03045 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1168 purK from Yersinia pestis CO92 Yersinia pestis CO92 1175898 16123254 YPO3077 NP_406567.1 phosphoribosylaminoimidazole carboxylase ATPase subunit Virulence factor MUTATION: purK mutant is attenuated in mice (Flashner et al., 2004). 14742535
1169 nlpD from Yersinia pestis CO92 Yersinia pestis CO92 1176173 16123506 YPO3356 NP_406819.1 predicted outer membrane lipoprotein Virulence factor MUTATION: nlpD mutant is attenuated in mice (Tidhar et al., 2009). 19759820
1170 pcm from Yersinia pestis CO92 Yersinia pestis CO92 1176174 16123507 YPO3357 NP_406820.1 protein-L-isoaspartate O-methyltransferase Virulence factor MUTATION: pcm mutant is attenuated in mice (Flashner et al., 2004). 14742535
1171 relA from Yersinia pestis CO92 Yersinia pestis CO92 1176197 16123529 YPO3380 NP_406842.1 GDP/GTP pyrophosphokinase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
1172 YPO3398 Yersinia pestis CO92 1176215 16123547 YPO3398 NP_406860.1 glutamyl-Q tRNA(Asp) synthetase Virulence factor MUTATION: yadBC double mutant is less invasive of HeLa cells compared to the wild type and decreased virulence in bubonic plague in mice (Forman et al., 2008). 18025093
1173 greA from Yersinia pestis CO92 Yersinia pestis CO92 1176324 16123651 YPO3505 NP_406964.1 transcription elongation factor GreA Virulence factor MUTATION: greA mutants are attenuated in mice (Flashner et al., 2004). 14742535
1174 purH from Yersinia pestis CO92 Yersinia pestis CO92 1176554 16123865 YPO3728 NP_407178.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Virulence factor MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004). 14742535
1175 YPO3973 Yersinia pestis CO92 1176811 16124100 YPO3973 NP_407413.1 metalloprotease Virulence factor MUTATION: YPO3973 mutant is attenuated in mice (Flashner et al., 2004). 14742535
1176 yapE from Yersinia pestis CO92 Yersinia pestis CO92 1176822 16124111 YPO3984 NP_407424.1 putative autotransporter protein Virulence factor MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model (Lawrenz et al., 2009). 18936182
1773 purH from Yersinia pestis Antiqua Yersinia pestis Antiqua 4118909 108809592 YPA_3601 YP_653508.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Virulence factor MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004). 14742535
1774 relA from Yersinia pestis Antiqua Yersinia pestis Antiqua 4120004 108808868 YPA_2877 YP_652784.1 GDP/GTP pyrophosphokinase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
1775 greA from Yersinia pestis Antiqua Yersinia pestis Antiqua 4121636 108806053 YPA_0055 YP_649969.1 transcription elongation factor GreA Virulence factor MUTATION: greA mutants are attenuated in mice (Flashner et al., 2004). 14742535
1776 pcm from Yersinia pestis Antiqua Yersinia pestis Antiqua 4122242 108808777 YPA_2786 YP_652693.1 protein-L-isoaspartate O-methyltransferase Virulence factor MUTATION: pcm mutant is attenuated in mice (Flashner et al., 2004). 14742535
1777 ssrA from Yersinia pestis Antiqua Yersinia pestis Antiqua 4122330 0 YPA_r031 - tmRNA Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1778 smpB from Yersinia pestis Antiqua Yersinia pestis Antiqua 4122331 108806576 YPA_0579 YP_650492.1 SsrA-binding protein Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1813 smpB from Yersinia pestis Nepal516 Yersinia pestis Nepal516 4123391 108813057 YPN_2897 YP_648824.1 SsrA-binding protein Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1814 ssrA from Yersinia pestis Nepal516 Yersinia pestis Nepal516 4123392 0 YPN_r084 - tmRNA Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1815 relA from Yersinia pestis Nepal516 Yersinia pestis Nepal516 4123547 108810878 YPN_0713 YP_646645.1 GDP/GTP pyrophosphokinase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
1816 purH from Yersinia pestis Nepal516 Yersinia pestis Nepal516 4124166 108810403 YPN_0237 YP_646170.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Virulence factor MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004). 14742535
1817 pcm from Yersinia pestis Nepal516 Yersinia pestis Nepal516 4124797 108810901 YPN_0736 YP_646668.1 protein-L-isoaspartate O-methyltransferase Virulence factor MUTATION: pcm mutant is attenuated in mice (Flashner et al., 2004). 14742535
1818 ompX from Yersinia pestis Nepal516 Yersinia pestis Nepal516 4125180 108812262 YPN_2100 YP_648029.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
1819 greA from Yersinia pestis Nepal516 Yersinia pestis Nepal516 4125871 108813409 YPN_3249 YP_649176.1 transcription elongation factor GreA Virulence factor MUTATION: greA mutants are attenuated in mice (Flashner et al., 2004). 14742535
1820 greA from Yersinia pestis Pestoides F Yersinia pestis Pestoides F 5062094 145600801 YPDSF_3554 YP_001164877.1 transcription elongation factor GreA Virulence factor MUTATION: greA mutants are attenuated in mice (Flashner et al., 2004). 14742535
1821 relA from Yersinia pestis Pestoides F Yersinia pestis Pestoides F 5062871 145600237 YPDSF_2980 YP_001164313.1 GDP/GTP pyrophosphokinase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
1822 pcm from Yersinia pestis Pestoides F Yersinia pestis Pestoides F 5062894 145600260 YPDSF_3003 YP_001164336.1 protein-L-isoaspartate O-methyltransferase Virulence factor MUTATION: pcm mutant is attenuated in mice (Flashner et al., 2004). 14742535
1823 purH from Yersinia pestis Pestoides F Yersinia pestis Pestoides F 5063065 145600973 YPDSF_3726 YP_001165049.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Virulence factor MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004). 14742535
1824 smpB from Yersinia pestis Pestoides F Yersinia pestis Pestoides F 5063531 145599861 YPDSF_2596 YP_001163937.1 SsrA-binding protein Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1825 ssrA from Yersinia pestis Pestoides F Yersinia pestis Pestoides F 5063532 0 YPDSF_R0054 - tmRNA Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1826 ompX from Yersinia pestis Pestoides F Yersinia pestis Pestoides F 5064369 145599198 YPDSF_1918 YP_001163274.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
1926 yscH from Yersinia pestis Angola Yersinia pestis Angola 5798229 162417765 YpAngola_B0059 YP_001604490.1 type III secretion protein YopR Virulence factor MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis (Allaoui et al., 1995). 8709853
1927 yopK from Yersinia pestis Angola Yersinia pestis Angola 5798230 162417795 YpAngola_B0015 YP_001604448.1 YopK protein Virulence factor MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days (Straley and Bowmer, 1986). 3002984
1928 lcrH from Yersinia pestis Angola Yersinia pestis Angola 5798234 162417760 YpAngola_B0031 YP_001604462.1 type III secretion low calcium response chaperone LcrH Virulence factor MUTATION: lcrH mutant is avirulent in mice (Price and Straley, 1989). 2707857
1929 lcrF from Yersinia pestis Angola Yersinia pestis Angola 5798258 162417806 YpAngola_B0050 YP_001604481.1 thermoregulatory protein LcrF Virulence factor MUTATION: lcrF mutant is attenuated in mice (Flashner et al., 2004). 14742535
1930 yopE from Yersinia pestis Angola Yersinia pestis Angola 5798272 162417742 YpAngola_B0003 YP_001604439.1 outer membrane virulence protein YopE Virulence factor MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice (Rosqvist et al., 1990). 2191183
1931 yopH from Yersinia pestis Angola Yersinia pestis Angola 5798273 162417751 YpAngola_B0067 YP_001604497.1 protein-tyrosine-phosphatase YopH Virulence factor MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996). 8809758
1932 yopB from Yersinia pestis Angola Yersinia pestis Angola 5798275 162417812 YpAngola_B0030 YP_001604461.1 translocator protein YopB Virulence factor MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (Håkansson et al., 1996). 8918459
1933 yopM from Yersinia pestis Angola Yersinia pestis Angola 5798276 162417819 YpAngola_B0025 YP_001604457.1 effector protein YopM Virulence factor MUTATION: yopM mutant is attenuated in mice compared to the wild type (Leung et al., 1990). 2401564
1934 yopT from Yersinia pestis Angola Yersinia pestis Angola 5798299 162417779 YpAngola_B0016 YP_001604449.1 cysteine protease YopT Virulence factor TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998). 9723929
1935 yopD from Yersinia pestis Angola Yersinia pestis Angola 5798303 162417734 YpAngola_B0029 YP_001604460.1 translocator protein YopD Virulence factor MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991). 1937815
1936 lcrV from Yersinia pestis Angola Yersinia pestis Angola 5798320 162417744 YpAngola_B0032 YP_001604463.1 virulence-associated V antigen LcrV Virulence factor MUTATION: lcrV mutants are avirulent in mice (Skrzypek and Straley, 1995). 7730287
1937 pla from Yersinia pestis Angola Yersinia pestis Angola 5798447 162417902 YpAngola_0009 YP_001604531.1 plasminogen activator Pla Virulence factor MUTATION: pla mutant is attenuated in mice (Sodeinde et al., 1992). 1439793
1938 pla from Yersinia pestis Angola Yersinia pestis Angola 5798450 162417870 YpAngola_0023 YP_001604542.1 plasminogen activator Pla Virulence factor MUTATION: pla mutant is attenuated in mice (Sodeinde et al., 1992). 1439793
1939 spoT from Yersinia pestis Angola Yersinia pestis Angola 5798508 162419160 YpAngola_A0043 YP_001604684.1 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
1940 ail from Yersinia pestis Angola Yersinia pestis Angola 5798908 162418778 YpAngola_A0444 YP_001605049.1 attachment invasion locus protein Virulence factor MUTATION: a Y. pestis ail deletion mutant was rapidly killed by sera from all mammals tested except mice (Bartra et al., 2008). 18025094
1941 purH from Yersinia pestis Angola Yersinia pestis Angola 5798929 162419129 YpAngola_A0465 YP_001605070.1 bifunctional purine biosynthesis protein PurH Virulence factor MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004). 14742535
1942 pcm from Yersinia pestis Angola Yersinia pestis Angola 5799423 162418533 YpAngola_A0960 YP_001605524.1 protein-L-isoaspartate O-methyltransferase Virulence factor MUTATION: pcm mutant is attenuated in mice (Flashner et al., 2004). 14742535
1943 relA from Yersinia pestis Angola Yersinia pestis Angola 5799446 162418825 YpAngola_A0983 YP_001605545.1 GTP pyrophosphokinase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
1944 purK from Yersinia pestis Angola Yersinia pestis Angola 5799740 162419683 YpAngola_A1274 YP_001605809.1 phosphoribosylaminoimidazole carboxylase, ATPase subunit Virulence factor MUTATION: purK mutant is attenuated in mice (Flashner et al., 2004). 14742535
1945 ssrA from Yersinia pestis Angola Yersinia pestis Angola 5799838 0 YpAngola_A4223 - tmRNA Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1946 smpB from Yersinia pestis Angola Yersinia pestis Angola 5799839 162421221 YpAngola_A1372 YP_001605898.1 SsrA-binding protein Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
1947 ompX from Yersinia pestis Angola Yersinia pestis Angola 5800238 162418882 YpAngola_A1767 YP_001606256.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
1948 fyuA from Yersinia pestis Angola Yersinia pestis Angola 5800563 162421186 YpAngola_A2093 YP_001606551.1 yersiniabactin/pesticin receptor FyuA Virulence factor MUTATION: psn (fyuA) mutant is unable to grow on iron-deficient media at 37 degrees C (Fetherston et al., 1995). 7896707
1949 irp2 from Yersinia pestis Angola Yersinia pestis Angola 5800568 162419029 YpAngola_A2098 YP_001606556.1 yersiniabactin synthetase, HMWP2 component Virulence factor MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media (Fetherston et al., 1995). 7896707
1950 ybtP from Yersinia pestis Angola Yersinia pestis Angola 5800570 162421511 YpAngola_A2100 YP_001606558.1 yersiniabactin ABC transporter, ATP-binding/permease protein Virulence factor MUTATION: ybtP mutant is avirulent in mouse bubonic plague model (Fetherston et al., 1999). 10231486
1951 lpp from Yersinia pestis Angola Yersinia pestis Angola 5801054 162419719 YpAngola_A2583 YP_001606992.1 major outer membrane lipoprotein Virulence factor MUTATION: lpp deletion mutant is attenuated in mice (Liu et al., 2010). 19737605
1952 yfeA from Yersinia pestis Angola Yersinia pestis Angola 5801102 162419227 YpAngola_A2630 YP_001607037.1 chelated iron ABC transporter, periplasmic iron binding protein YfeA Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
1953 yfeB from Yersinia pestis Angola Yersinia pestis Angola 5801103 162419654 YpAngola_A2631 YP_001607038.1 chelated iron ABC transporter, ATP-binding protein YfeB Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
1954 phoP from Yersinia pestis Angola Yersinia pestis Angola 5801327 162418657 YpAngola_A2855 YP_001607237.1 transcriptional regulatory protein PhoP Virulence factor MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain (Oyston et al., 2000). 10816493
1955 pgm from Yersinia pestis Angola Yersinia pestis Angola 5802050 162420967 YpAngola_A3574 YP_001607899.1 phosphoglucomutase, alpha-D-glucose phosphate-specific Virulence factor MUTATION: pgm mutant of Y. pestis is attenuated in mice (Welkos et al., 2002). 12009274
1956 crp from Yersinia pestis Angola Yersinia pestis Angola 5802179 162420734 YpAngola_A3702 YP_001608021.1 catabolite gene activator Virulence factor MUTATION: crp mutant is attenuated in mice (Sun et al., 2010). 20086087
1957 greA from Yersinia pestis Angola Yersinia pestis Angola 5802460 162421747 YpAngola_A3982 YP_001608277.1 transcription elongation factor GreA Virulence factor MUTATION: greA mutants are attenuated in mice (Flashner et al., 2004). 14742535
1958 ymt from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236150 149192814 YPE_4333 YP_001294045.1 murine toxin Virulence factor MUTATION: ymt mutants are unable to block X. cheopsis fleas and have low survival rates in the flea gut (Hinnebusch et al., 2002). 11976454
1959 caf1M from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236158 149192807 YPE_4324 YP_001294038.1 putative F1 chaperone protein Virulence factor MUTATION: caf1M mutants are attenuated in mice (Welkos et al., 2004). 14711524
1960 caf1A from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236159 149192806 YPE_4323 YP_001294037.1 putative F1 capsule anchoring protein Virulence factor MUTATION: caf1A mutants are attenuated in mice (Welkos et al., 2004). 14711524
2479 yopK from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236061 149192717 YPE_4233 YP_001293949.1 secreted targeting protein, possible regulator, Type III system Virulence factor MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days (Straley and Bowmer, 1986). 3002984
2480 yopT from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236062 149192716 YPE_4232 YP_001293948.1 Translocated cysteine protease/Rho GTPase toxin Virulence factor TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998). 9723929
2481 yopM from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236067 149192712 YPE_4227 YP_001293944.1 leucine-rich 15-repeat translocated effector protein Virulence factor MUTATION: yopM mutant is attenuated in mice compared to the wild type (Leung et al., 1990). 2401564
2482 yopD from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236068 149192711 YPE_4226 YP_001293943.1 putative secreted pore/translocation protein Virulence factor MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991). 1937815
2483 yopB from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236069 149192710 YPE_4225 YP_001293942.1 putative secreted pore/translocation protein Virulence factor MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (Håkansson et al., 1996). 8918459
2484 lcrH from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236070 149192709 YPE_4224 YP_001293941.1 putative yopB/yopD chaperone Virulence factor MUTATION: lcrH mutant is avirulent in mice (Price and Straley, 1989). 2707857
2485 lcrV from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236071 149192708 YPE_4223 YP_001293940.1 V antigen Virulence factor MUTATION: lcrV mutants are avirulent in mice (Skrzypek and Straley, 1995). 7730287
2486 lcrF from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236089 149192690 YPE_4205 YP_001293922.1 putative thermoregulatory protein Virulence factor MUTATION: lcrF mutant is attenuated in mice (Flashner et al., 2004). 14742535
2487 yscH from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236097 149192682 YPE_4197 YP_001293914.1 type III secreted virulence protein Virulence factor MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis (Allaoui et al., 1995). 8709853
2488 yopH from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236107 149192673 YPE_4187 YP_001293905.1 translocated protein-tyrosine kinase, inhibitor of phagocytosis Virulence factor MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996). 8809758
2489 ypkA from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236112 149192671 YPE_4182 YP_001293903.1 Protein kinase, host Rho GTPase toxin Virulence factor MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice (Galyov et al., 1993). 8441468
2490 yopE from Yersinia pestis CA88-4125 Yersinia pestis CA88-4125 5236139 149192652 YPE_4152 YP_001293884.1 Translocated host-GTPase-activating protein Virulence factor MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice (Rosqvist et al., 1990). 2191183
2491 ymt from Yersinia pestis Yersinia pestis 3077319 52788173 pG8786_122 YP_094001.1 toxin protein Virulence factor MUTATION: ymt mutants are unable to block X. cheopsis fleas and have low survival rates in the flea gut (Hinnebusch et al., 2002). 11976454
2492 caf1A from Yersinia pestis Yersinia pestis 3077339 52788125 pG8786_073 YP_093953.1 F1 capsule anchoring protein Virulence factor MUTATION: caf1A mutants are attenuated in mice (Welkos et al., 2004). 14711524
2493 caf1M from Yersinia pestis Yersinia pestis 3077340 52788126 pG8786_074 YP_093954.1 F1 capsule protein Virulence factor MUTATION: caf1M mutants are attenuated in mice (Welkos et al., 2004). 14711524
2494 caf1M from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767618 45478669 YP_pMT084 NP_995525.1 putative F1 chaperone protein Virulence factor MUTATION: caf1M mutants are attenuated in mice (Welkos et al., 2004). 14711524
2495 caf1A from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767657 45478668 YP_pMT083 NP_995524.1 putative F1 capsule anchoring protein Virulence factor MUTATION: caf1A mutants are attenuated in mice (Welkos et al., 2004). 14711524
2496 ymt from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767661 45478703 YP_pMT119 NP_995559.1 murine toxin Virulence factor MUTATION: ymt mutants are unable to block X. cheopsis fleas and have low survival rates in the flea gut (Hinnebusch et al., 2002). 11976454
2497 sycD from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767486 45478554 YP_pCD53 NP_995381.1 putative yopB/yopD chaperone SycD Virulence factor MUTATION: lcrH (sycD) mutant is avirulent in mice (Price and Straley, 1989). 2707857
2498 yopB from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767487 45478555 YP_pCD54 NP_995382.1 putative Yop targeting protein YopB Virulence factor MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (Håkansson et al., 1996). 8918459
2499 yopD from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767507 45478556 YP_pCD55 NP_995383.1 putative Yop negative regulation/targeting component YopD Virulence factor MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991). 1937815
2500 yopT from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767512 45478564 YP_pCD67 NP_995391.1 putative cytotoxic effector protein YopT Virulence factor TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998). 9723929
2501 yopH from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767526 45478518 YP_pCD17 NP_995345.1 putative protein-tyrosine phosphatase Yop effector YopH Virulence factor MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996). 8809758
2502 lcrV from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767532 45478553 YP_pCD52 NP_995380.1 V antigen LcrV Virulence factor MUTATION: lcrV mutants are avirulent in mice (Skrzypek and Straley, 1995). 7730287
2503 yopQ from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767553 45478565 YP_pCD68 NP_995392.1 putative virulence determinant protein YopQ Virulence factor MUTATION: yopK (yopQ) mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days (Straley and Bowmer, 1986). 3002984
2504 virF from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767558 45478535 YP_pCD34 NP_995362.1 putative thermoregulatory protein VirF Virulence factor MUTATION: lcrF mutant is attenuated in mice (Flashner et al., 2004). 14742535
2505 ypkA from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767571 45478514 YP_pCD13 NP_995341.1 putative targeted effector protein kinase YpkA Virulence factor MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice (Galyov et al., 1993). 8441468
2506 yopM from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767574 45478559 YP_pCD60 NP_995386.1 putative targeted effector protein YopM Virulence factor MUTATION: yopM mutant is attenuated in mice compared to the wild type (Leung et al., 1990). 2401564
2507 yscH from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767576 45478527 YP_pCD26 NP_995354.1 putative type III secretion protein YscH Virulence factor MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis (Allaoui et al., 1995). 8709853
2508 yopE from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767578 45478574 YP_pCD81 NP_995401.1 putative outer membrane virulence protein YopE Virulence factor MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice (Rosqvist et al., 1990). 2191183
2509 ypkA from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149271 31795457 Y0009 NP_857907.1 secreted protein kinase Virulence factor MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice (Galyov et al., 1993). 8441468
2510 yopH from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149274 31795460 Y0013 NP_857910.1 secreted effector protein Virulence factor MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996). 8809758
2511 yscH Yersinia pestis 1149284 31795520 Y0024 NP_857920.1 secreted protein Virulence factor MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis (Allaoui et al., 1995). 8709853
2512 lcrF from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149292 31795474 Y0032 NP_857928.1 transcriptional regulator Virulence factor MUTATION: lcrF mutant is attenuated in mice (Flashner et al., 2004). 14742535
2513 lcrV from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149310 31795491 Y0050 NP_857946.1 secreted effector protein Virulence factor MUTATION: lcrV mutants are avirulent in mice (Skrzypek and Straley, 1995). 7730287
2514 lcrH from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149311 31795492 Y0051 NP_857947.1 secretion chaperone Virulence factor MUTATION: lcrH mutant is avirulent in mice (Price and Straley, 1989). 2707857
2515 yopB from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149312 31795493 Y0052 NP_857948.1 secreted effector protein Virulence factor MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (Håkansson et al., 1996). 8918459
2516 yopD from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149313 31795494 Y0053 NP_857949.1 secreted effector protein Virulence factor MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991). 1937815
2517 yopM from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149317 31795498 Y0059 NP_857953.1 Yop targeted effector protein Virulence factor MUTATION: yopM mutant is attenuated in mice compared to the wild type (Leung et al., 1990). 2401564
2518 yopT from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149322 31795525 Y0065 NP_857958.1 Yop targeted effector Virulence factor TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998). 9723929
2519 yopK from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149323 31795502 Y0066 NP_857959.1 Yop targeting protein Virulence factor MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days (Straley and Bowmer, 1986). 3002984
2520 yopE from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149332 31795510 Y0077 NP_857967.1 secreted effector Virulence factor MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice (Rosqvist et al., 1990). 2191183
2521 pla from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149148 31795332 YPKp07 NP_857784.1 outer membrane protease Virulence factor MUTATION: pla mutant is attenuated in mice (Sodeinde et al., 1992). 1439793
2522 yscH from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149097 31795264 YKCD1p10 NP_857725.1 secreted effector protein Virulence factor MUTATION: The LD50 for the mouse of the yscH mutant was 10-fold higher than that of the parental strain indicating that YopR is involved in pathogenesis (Allaoui et al., 1995). 8709853
2523 lcrF from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149104 31795271 YKCD1p18 NP_857733.1 transcriptional regulator Virulence factor MUTATION: lcrF mutant is attenuated in mice (Flashner et al., 2004). 14742535
2524 lcrV from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149118 31795291 YKCD1p35 NP_857751.1 secreted effector protein Virulence factor MUTATION: lcrV mutants are avirulent in mice (Skrzypek and Straley, 1995). 7730287
2525 lcrH from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149119 31795292 YKCD1p36 NP_857752.1 secretion chaperone Virulence factor MUTATION: lcrH mutant is avirulent in mice (Price and Straley, 1989). 2707857
2526 yopB from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149120 31795293 YKCD1p37 NP_857753.1 secreted effector protein Virulence factor MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells (Håkansson et al., 1996). 8918459
2527 yopD from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149121 31795294 YKCD1p38 NP_857754.1 secreted effector protein Virulence factor MUTATION: yopD mutants are unable to induce cytotoxicity in HeLa cells (Rosqvist et al., 1991). 1937815
2528 yopM from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149123 31795297 YKCD1p41 NP_857756.1 secreted effector protein Virulence factor MUTATION: yopM mutant is attenuated in mice compared to the wild type (Leung et al., 1990). 2401564
2529 yopK from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149124 31795300 YKCD1p49 NP_857759.1 targeting protein Virulence factor MUTATION: yopK mutant has an increased LD50 dose in mice, and infected mice died after 5 days as compared to mice infected with the wild type died after just 3 days (Straley and Bowmer, 1986). 3002984
2530 yopE from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149129 31795304 YKCD1p59 NP_857762.1 secreted effector protein Virulence factor MUTATION: yopE mutants are attenuated after oral or intraperitoneal infection in mice, but are not attenuated after intravenous infection in mice (Rosqvist et al., 1990). 2191183
2531 ypkA from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149139 31795319 YKCD1p81 NP_857776.1 similar to Yersinia pseudotuberculosis protein kinase A Virulence factor MUTATION: ypkA mutants of Y. pseudotuberculosis are attenuated in mice (Galyov et al., 1993). 8441468
2532 yopH from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149142 31795323 YKCD1p83 NP_857779.1 secreted effector protein Virulence factor MUTATION: yopH mutants are unable to resist phagocytosis by J774 cells, while wild type Yersinia is able to resist phagocytosis (Andersson et al., 1996). 8809758
2533 yopT from Yersinia pestis KIM 10 Yersinia pestis KIM 10 2700511 31795299 YKCD1p48 NP_857758.1 secreted effector protein Virulence factor TOXIN: Infection of HeLa cells with a mutant strain devoid of the five known Yop effectors (deltaHOPEM strain) but producing YopT resulted in the alteration of the cell cytoskeleton and the disruption of the actin filament structure. The cytotoxic effect is due to YopT (Iriarte and Cornelis, 1998). 9723929
2534 caf1A from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149093 31795235 YPKMT066 NP_857693.1 F1 capsule protein Virulence factor MUTATION: caf1A mutants are attenuated in mice (Welkos et al., 2004). 14711524
2535 caf1M from Yersinia pestis KIM 10 Yersinia pestis KIM 10 1149094 31795236 YPKMT067 NP_857694.1 F1 capsule protein Virulence factor MUTATION: caf1M mutants are attenuated in mice (Welkos et al., 2004). 14711524
2536 ugd Yersinia pestis biovar Microtus str. 91001 2763750 45441774 YP_1973 NP_993313.1 putative nucleotide sugar dehydrogenase Virulence factor MUTATION: ugd mutant had defects in intracellular survival in macrophages (Grabenstein et al., 2006). 16790745
2537 pcm from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2763931 45440187 YP_0330 NP_991726.1 protein-L-isoaspartate O-methyltransferase Virulence factor MUTATION: pcm mutant is attenuated in mice (Flashner et al., 2004). 14742535
2538 hfq from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764073 45440383 YP_0529 NP_991922.1 RNA-binding protein Hfq Virulence factor MUTATION: hfq mutant is highly attenuated in mice after subcutaneous or intravenous injection and has attenuated survival in macrophages (Geng et al., 2009). 19593436
2539 greA from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764186 45440432 YP_0578 NP_991971.1 transcription elongation factor GreA Virulence factor MUTATION: greA mutants are attenuated in mice (Flashner et al., 2004). 14742535
2540 ompX from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764362 45442111 YP_2321 NP_993650.1 outer membrane protein X Virulence factor MUTATION: ompX mutants are attenuated in their ability to attach to and invade HeLa cells (Kolodziejek et al., 2007). 17768237
2541 ssrA from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764482 0 YP_s4 - miscRNA Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
2542 smpB from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764498 45440889 YP_1055 NP_992428.1 SsrA-binding protein Virulence factor MUTATION: smpB ssrA mutant is attenuated in mice (Okan et al., 2010). 20065026
2543 yfeA from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764801 45442017 YP_2227 NP_993556.1 periplasmic-binding protein Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
2544 yfeB from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764839 45442018 YP_2228 NP_993557.1 ATP-binding transport protein Virulence factor MUTATION: yfeAB mutant is attenuated when given subcutaneously to mice and is avirulent when given to mice intravenously (Bearden and Perry, 1999). 10231495
2545 ybtP from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764925 45441470 YP_1656 NP_993009.1 permease and ATP-binding protein of yersiniabactin-iron ABC transporter Virulence factor MUTATION: ybtP mutant is avirulent in mouse bubonic plague model (Fetherston et al., 1999). 10231486
2546 irp2 from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764958 45441468 YP_1654 NP_993007.1 yersiniabactin biosynthetic protein Virulence factor MUTATION: irp2 mutants are unable to grow at 37 degrees in iron deficient media (Fetherston et al., 1995). 7896707
2547 fyuA from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2764984 45441463 YP_1649 NP_993002.1 pesticin/yersiniabactin receptor protein Virulence factor MUTATION: psn (fyuA) mutant is unable to grow on iron-deficient media at 37 degrees C (Fetherston et al., 1995). 7896707
2548 yapE from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2765067 45443096 YP_3347 NP_994635.1 putative autotransporter protein Virulence factor MUTATION: yapE mutant is attenuated in mice and has impaired colonization in bubonic plague model (Lawrenz et al., 2009). 18936182
2549 pgm from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2765450 45442271 YP_2488 NP_993810.1 phosphoglucomutase Virulence factor MUTATION: pgm mutant of Y. pestis is attenuated in mice (Welkos et al., 2002). 12009274
2550 lpp from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2765473 45441973 YP_2181 NP_993512.1 major outer membrane lipoprotein Virulence factor MUTATION: lpp deletion mutant is attenuated in mice (Liu et al., 2010). 19737605
2551 purK from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2765634 45440690 YP_0847 NP_992229.1 phosphoribosylaminoimidazole carboxylase ATPase subunit Virulence factor MUTATION: purK mutant is attenuated in mice (Flashner et al., 2004). 14742535
2552 purH from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2765673 45442845 YP_3091 NP_994384.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Virulence factor MUTATION: purH mutant is attenuated in mice (Flashner et al., 2004). 14742535
2553 phoP from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2765857 45441575 YP_1764 NP_993114.1 DNA-binding response regulator in two-component regulatory system with PhoQ Virulence factor MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain (Oyston et al., 2000). 10816493
2554 msbB from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2766044 45441708 YP_1906 NP_993247.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Virulence factor MUTATION: lpxM (msbB) mutant is attenuated in mice and guinea pigs (Feodorova et al., 2007). 17913308
2555 psaA from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2766170 45441116 YP_1289 NP_992655.1 pH 6 Antigen fimbrial subunit Virulence factor MUTATION: psaA mutants have a 100-fold reduced 50% lethal dose in mice (Lindler et al., 1990). 2164509
2556 spoT from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2766260 45439904 YP_0039 NP_991443.1 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
2557 mgtC from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2766450 45441600 YP_1790 NP_993139.1 Mg(2+) transport ATPase protein C Virulence factor MUTATION: mgtC mutants are defective in early intracellular survival in macrophages compared to wild type Y. pestis (Grabenstein et al., 2006). 16790745
2558 dam from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2766547 45440018 YP_0156 NP_991557.1 DNA adenine methylase Virulence factor MUTATION: dam mutant is attenuated in mice (Robinson et al., 2005). 16188402
2559 psaE from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2766548 45441118 YP_1291 NP_992657.1 putative regulatory protein Virulence factor MUTATION: psaE mutants are attenuated in mice (Lindler et al., 1990). 2164509
2560 relA from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2766682 45440165 YP_0306 NP_991704.1 GDP/GTP pyrophosphokinase Virulence factor MUTATION: relA spoT deletion mutants are attenuated in mice (Sun et al., 2009). 19701461
2561 crp from Yersinia pestis biovar Microtus str. 91001 Yersinia pestis biovar Microtus str. 91001 2767357 45440035 YP_0174 NP_991574.1 cAMP-regulatory protein Virulence factor MUTATION: crp mutant is attenuated in mice (Sun et al., 2010). 20086087