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Found 11 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4479 opb Leishmania major 4581756 4581757 AAD24761.1 oligopeptidase B Virulence factor MUTATION: opb mutant is attenuated in murine macrophages (Munday et al., 2011). 20883728
4480 LPG1 Leishmania major 7239376 7239377 AAF43209.1 putative beta galactofuranosyl transferase Virulence factor MUTATION: lpg1 mutant are attenuated in mice and in macrophages (Späth et al., 2000).
4481 LIT1 Leishmania major strain Friedlin 5654245 157873579 LmjF31.3060 CT005268 XP_001685297 Virulence factor MUTATION: Inactivation of LIT1 gene results in attenuated virulence in murine footpad model of infection and reduced viability and replication in bone marrow macrophages (Marquis and Gros, 2007).
4484 GP63 Leishmania major strain Friedlin 5649648 157865343 LmjF10.0480 CT005249 XP_001681379 Virulence factor MUTATION: gp63 mutant is attenuated for survival in murine macrophages (McGwire and Chang, 1994).
5154 PDI 25990151 disulfide isomerase PDI Virulence factor Specific PDI inhibitors abolished the enzymatic activity of the recombinant protein and profoundly affected parasite growth. (Ben et al., 2002) 12065498
5155 LPG2 Leishmania major strain Friedlin 5655087 157876111 LMJF_34_3120 FR796430 XP_001686416 Virulence factor the lpg2(-)REV revertant was unable to synthesize LPG2-dependent PGs in the promastigote stage and thus remained highly attenuated in the ability to induce infection. (Späth et al., 2004) 15155672
5156 DAT Leishmania major strain Friedlin 5654871 157875635 LMJF_34_1090 FR796430 XP_001686202 Virulence factor LmDAT is the only dihydroxyacetone phosphate acyltransferase of the L. major localized in the peroxisome, important for growth and survival and essential for virulence.
(Zufferey and Ben, 2006)
5158 ATG4.2 Leishmania major strain Friedlin 5653545 157872135 LMJF_30_0270 FR796426 XP_001684616 Virulence factor the low infectivity of Δatg4.2 demonstrates that autophagy is important for the virulence of the parasite. (Williams et al., 2013) 23166325
5196 APX Leishmania major strain Friedlin 5654759 157875406 LMJF_34_0070 FR796430 XP_001686096 Virulence factor The null mutant cells exhibit hypervirulence after infection with macrophages as well as inoculation into BALB/c mice; in contrast, overexpressing cells show avirulence. LmAPX is an important factor for controlling parasite differentiation and survival within macrophages.(Pal et al., 2010)
5209 PLA2 Leishmania major strain Friedlin 3684469 72548599 LmjF35.3020 CP000081 XP_843407 Virulence factor Deletion of PLA2/PAF-AH in Leishmania Major is dramatically attenuated the virulence in BALB/c mice(Pawlowic and Zhang, 2012) 22954769
5215 GLF 59859955 UDP-galactopyranose mutase Virulence factor glf(-) mutant is deficient in LPG backbone and expresses truncated glycoinositolphospholipids. These structural changes do not influence the in vitro growth of the parasite but lead to an attenuation of virulence comparable with that observed with a mutant exclusively deficient in LPG.(Kleczka et al., 2007)