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Found 14 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4531 EhCP5 Entamoeba histolytica 114796864 cysteine proteinase 5 Virulence factor MUTATION: Parasites with antisense inhibition of EhCP5 were unable to disrupt LS 174T or HT-29F Cl.16 cell monolayers (Moncada et al., 2006).
16530514
4532 RabA Entamoeba histolytica 2623646 2623647 AAB86482.1 rab-like GTP-binding protein Virulence factor MUTATION: EhRabA mutant has reduced adhesion and host cell lysis of CHO monolayers (Welter et al., 2005).
15760656
4533 kerp1 Entamoeba histolytica HM-1:IMSS 3407934 67476017 EHI_098210 DS571169 XP_653629 Virulence factor MUTATION: parasites with blocked expression of kerp1 are attenuated in causing liver abscesses in hamsters (Santi-Rocca et al., 2008).
17711481
4534 ehap-a Entamoeba histolytica HM-1:IMSS 3410347 67481359 EHI_118270 DS571183 XP_656029 Virulence factor MUTATION: Ehap-a gene was silenced resulting in a nonvirulent phenotype in hamsters (Mirelman et al., 2008).
18493998
5177 CP5 114796866 cysteine proteinase 5 Virulence factor transfection and overexpression of ehcp5 was able to compensate the reduction of in vivo pathogenicity in parasites, which have been silenced for the gene encoding the pore-forming protein amoebapore A. In summary, these results further support the important role of EhCP5 in E. histolytica pathogenicity.(Tillack et al., 2006)
16753229
5178 EHI_118270 Entamoeba histolytica HM-1:IMSS 3410347 67481359 EHI_118270 DS571183 XP_656029 Virulence factor Transfectants of virulent E. histolytica strain HM-1:IMSS, in which the expression of amoebapore was inhibited by approximately 60%, were significantly less pathogenic.
(Bracha et al., 1999)
10564488
5179 URE3-BP 10505244 URE3-BP sequence specific DNA binding protein Virulence factor Amebae induced to express a dominant positive mutant form of URE3-BP had an increase in an elongated morphology (30% +/- 6% versus 14% +/- 5%; P = 0.001), a 2-fold competitive advantage at invading the intestinal epithelium (P = 0.017), and a 3-fold increase in liver abscess size (0.1 +/- 0.1 g versus 0.036 +/- 0.1 g; P = 0.03). These results support a role for URE3-BP in virulence regulation.(Gilchrist et al., 2010)
20689746
5180 EHI_188210 Entamoeba histolytica HM-1:IMSS 3408004 67476172 EHI_188210 DS571206 XP_653689 Virulence factor we have confirmed that two genes that are upregulated by ROS confer increased resistance to oxidative stress and have identified an unexpected role of EhSIAF and EhPTPA in host cell adherence and a role of EhSIAF in parasite virulence.(Rastew et al., 2012)
23009748
5181 EHI_056680 Entamoeba histolytica HM-1:IMSS 3403382 67465868 EHI_056680 DS571423 XP_649092 Virulence factor we have confirmed that two genes that are upregulated by ROS confer increased resistance to oxidative stress and have identified an unexpected role of EhSIAF and EhPTPA in host cell adherence and a role of EhSIAF in parasite virulence.(Rastew et al., 2012)
23009748
5182 DPD Entamoeba histolytica HM-1:IMSS 3410647 183231113 EHI_012980 DS571168 XP_656317 Virulence factor dihydropyrimidine dehydrogenase (DPD) is crucial for the parasites growth when the availability of glucose is limited. These data contribute to our understanding of the parasites ability to survive in glucose-poor environments and reveal a new role for the DPD enzyme.
(Baumel-Alterzon et al., 2013)
23016994
5183 EHI_108720 Entamoeba histolytica HM-1:IMSS 3405630 67470724 EHI_108720 DS571346 XP_651325 Virulence factor EHI_108720, or HRM-binding protein, represents a new stress-responsive transcription factor in E. histolytica that controls a transcriptional regulatory network associated with oxidative stress. Overexpression of EHI_108720 increased parasite virulence.(Pearson et al., 2013)
23250742
5184 rabB 7144601 RabB Virulence factor we over expressed the wild type EhrabB gene and a mutant gene encoding for a protein (RabBN118I) unable to bind guanine nucleotides and therefore constitutively inactive. The over expression of the mutated protein in E. histolytica trophozoites provoked a dominant negative effect, reflected in a significant decrease of both phagocytosis and cytopathic effect as well as in a failure to produce hepatic abscesses in hamsters. These results confirm that EhRabB is involved in phagocytosis and virulence of E. histolytica.(Juárez-Hernández et al., 2013)
23268174
5185 EhCP112 Entamoeba histolytica HM-1:IMSS 6220496 183236363 EHI_010850 DS571817 XP_001914429 Virulence factor EhCP112 silencing produces a significant reduction in cytolysis and phagocytosis of target cells, indicating the participation of this proteinase in these events. EhCP112 is involved in the in vitro virulence of E. histolytica.(Ocádiz-Ruiz et al., 2013)
23981435
5222 igl1 15216659 Gal/GalNAc lectin Igl1 Virulence factor Dominant-negative mutations in the Gal/GalNAc lectin affect adhesion and cytolysis. (Gilchrist and Petri, 1999) 10458982