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Found 30 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4336 pbp1A Streptococcus agalactiae 2603V/R 1013087 22536482 SAG0298 NP_687333.1 penicillin-binding protein 1A Virulence factor MUTATION: pbp1A mutant is attenuated in rats (Jones et al., 2000). 10998175
4337 ciaR from Streptococcus agalactiae 2603V/R Streptococcus agalactiae 2603V/R 1013789 22537145 SAG0985 NP_687996.1 DNA-binding response regulator CiaR Virulence factor MUTATION: ciaR mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC (Quach et al., 2009). 19114476
4338 lmb from Streptococcus agalactiae 2603V/R Streptococcus agalactiae 2603V/R 1014041 22537388 SAG1234 NP_688239.1 laminin-binding surface protein Virulence factor MUTATION: lmb mutant has reduced invasion of human brain microvascular endothelial cells compared to the wildtype (Tenenbaum et al., 2007). 17400016
4339 csrS Streptococcus agalactiae 2603V/R 1014433 22537764 SAG1624 NP_688615.1 sensor histidine kinase CsrS Virulence factor MUTATION: csrS mutant is attenuated in mice (Jiang et al., 2005). 15659687
4340 csrR Streptococcus agalactiae 2603V/R 1014434 22537765 SAG1625 NP_688616.1 DNA-binding response regulator CsrR Virulence factor MUTATION: csrR mutant is attenuated in mice (Jiang et al., 2005). 15659687
4341 gbs1020 Streptococcus agalactiae NEM316 1030007 25011074 gbs1020 NP_735469.1 DNA-binding response regulator CiaR Virulence factor MUTATION: gbs1020 (CiaR) mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC (Quach et al., 2009). 19114476
4342 cpsD Streptococcus agalactiae NEM316 1030264 25011294 gbs1244 NP_735689.1 capsular polysaccharide chain length regulator/exporter Virulence factor MUTATION:cpsD mutant results in an unencapsulated strain which is avirulent in a neonatal rat model of sepsis compared to the wild type strain, and is also sensitive to killing by human phagocytes in vitro (Rubens et al., 1993). 8355611
4343 lmb from Streptococcus agalactiae NEM316 Streptococcus agalactiae NEM316 1030333 25011353 gbs1307 NP_735748.1 laminin-binding surface protein Virulence factor MUTATION: lmb mutant has reduced invasion of human brain microvascular endothelial cells compared to wildtype (Tenenbaum et al., 2007). 17400016
4344 scpB from Streptococcus agalactiae NEM316 Streptococcus agalactiae NEM316 1030336 25011354 gbs1308 NP_735749.1 streptococcal C5a peptidase Virulence factor MUTATION: scpB mutant has significantly reduced invasion of HEp2 and A549 human cell lines (Cheng et al., 2002). 11953377
4345 gbs1402 Streptococcus agalactiae NEM316 1030444 25011444 gbs1402 NP_735839.1 MarR family transcriptional regulator Virulence factor MUTATION: gbs1402 (pefR) mutant is attenuated in mice (Fernandez et al., 2010). 20421944
4346 gbs1477 Streptococcus agalactiae NEM316 1030552 25011519 gbs1477 NP_735914.1 hypothetical protein Virulence factor MUTATION: gbs1477 (pilB) mutant had significantly reduced invasion of hBMECs (Maisey et al., 2007). 17041051
4347 gbs1529 Streptococcus agalactiae NEM316 1030619 25011571 gbs1529 NP_735966.1 cell wall surface anchor family protein Virulence factor MUTATION: Deletion of srr1(gbs1529) in NCTC 10/84 resulted in a significant decrease in adherence to and invasion of hBMECs (van et al., 2009). 19392623
4370 pepX Streptococcus agalactiae A909 3685108 76786791 SAK_1744 YP_330344.1 x-prolyl-dipeptidyl aminopeptidase Virulence factor MUTATION: pepX mutant is attenuated in rats (Jones et al., 2000). 10998175
4371 cydA Streptococcus agalactiae A909 3685696 76787464 SAK_1750 YP_330350.1 cytochrome d ubiquinol oxidase, subunit II Virulence factor MUTATION: cydA mutant is attenuated in rats (Yamamoto et al., 2005). 15813741
4372 murF Streptococcus agalactiae A909 3685706 76788062 SAK_0893 YP_329515.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Virulence factor MUTATION: murF mutant is attenuated in rats (Jones et al., 2000). 10998175
4373 ciaR from Streptococcus agalactiae A909 Streptococcus agalactiae A909 3685802 76787511 SAK_1080 YP_329701.1 DNA-binding response regulator CiaR Virulence factor MUTATION: ciaR mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC (Quach et al., 2009). 19114476
4374 SAK_0517 Streptococcus agalactiae A909 3685804 76787513 SAK_0517 YP_329152.1 C protein alpha-antigen Virulence factor MUTATION: C protein alpha antigen mutant is attenuated in mice (Li et al., 1997). 9371832
4375 lmb from Streptococcus agalactiae A909 Streptococcus agalactiae A909 3685811 76787520 SAK_1319 YP_329931.1 laminin-binding surface protein Virulence factor MUTATION: lmb mutant has reduced invasion of human brain microvascular endothelial cells compared to the wildtype (Tenenbaum et al., 2007). 17400016
4376 carB Streptococcus agalactiae A909 3686058 76788218 SAK_1132 YP_329753.1 carbamoyl phosphate synthase large subunit Virulence factor MUTATION: carB mutant is attenuated in rats (Jones et al., 2000). 10998175
4377 scpB from Streptococcus agalactiae A909 Streptococcus agalactiae A909 3686098 76788661 SAK_1320 YP_329932.1 C5a peptidase ScpB Virulence factor MUTATION: scpB mutant had significantly reduced invasion of HEp2 and A549 human cell lines (Cheng et al., 2002). 11953377
4378 lepA Streptococcus agalactiae A909 3686142 76788416 SAK_1022 YP_329644.1 GTP-binding protein LepA Virulence factor MUTATION: lepA mutant is attenuated in rats (Jones et al., 2000). 10998175
4379 scrB from Streptococcus agalactiae A909 Streptococcus agalactiae A909 3686267 76788376 SAK_1703 YP_330305.1 sucrose-6-phosphate hydrolase Virulence factor MUTATION: scrB mutant is attenuated in rats (Jones et al., 2000). 10998175
4380 rpoE Streptococcus agalactiae A909 3686398 76787332 SAK_0156 YP_328830.1 DNA-directed RNA polymerase subunit delta Virulence factor MUTATION: rpoE mutant is attenuated in rats (Seepersaud et al., 2006). 16513739
4381 cpsY Streptococcus agalactiae A909 3686453 76788234 SAK_1263 YP_329877.1 transcriptional regulator CpsY Virulence factor MUTATION: An isogenic strain bearing a kanamycin insertion in mtaR (cpsY) was attenuated for survival in a neonatal-rat model of sepsis and grew poorly in human plasma (Shelver et al., 2003). 14594832
4382 pepN Streptococcus agalactiae A909 3686784 76788425 SAK_1081 YP_329702.1 aminopeptidase N Virulence factor MUTATION: pepN mutant is attenuated in rats (Jones et al., 2000). 10998175
4383 cylE Streptococcus agalactiae A909 3686789 76788430 SAK_0797 YP_329421.1 CylE protein Virulence factor MUTATION: cylE mutant has decreased invasion of lung epithelial cells (Doran et al., 2002). 11807693
4384 guaA Streptococcus agalactiae A909 3686928 76788259 SAK_1062 YP_329683.1 glutamine-hydrolyzing Virulence factor MUTATION: guaA mutant is attenuated in rats (Jones et al., 2000). 10998175
4385 lgt Streptococcus agalactiae A909 3687119 76788292 SAK_0863 YP_329485.1 prolipoprotein diacylglyceryl transferase Virulence factor MUTATION: lgt mutant has a significant reduction in adherence to human endothelial cells of fetal origin (Bray et al., 2009). 19383708
4468 fbsA Streptococcus agalactiae 6313 25956188 fibrinogen receptor FbsA Virulence factor MUTATION: fbsA mutant has attenuated growth in human blood (Schubert et al., 2002).
12406229
4877 Type III Capsule Streptococcus agalactiae Virulence factor MUTATION: a sialic-deficient type 3 capsular polysaccharide mutant was avirulent in in a neonatal rat model of GBS infection and was sensitive to killing by human leukocytes in vitro (Wessels et al., 1992). 1309720