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Found 77 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4271 SPy_0019 Streptococcus pyogenes M1 GAS 900379 15674263 SPy_0019 AE004092 NP_268436 putative secreted protein Virulence factor MUTATION: SPy_0019 (cdhA) mutant has severe cell division, growth defects and is attenuated in mice (Pancholi et al., 2010). 20643653
4272 nga Streptococcus pyogenes M1 GAS 900488 15674370 SPy_0165 NP_268544.1 NAD glycohydrolase Virulence factor MUTATION: nga mutant is attenuated in mice (Tatsuno et al., 2010). 20470439
4273 speJ from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 900684 15674561 SPy_0436 NP_268735.1 putative exotoxin (superantigen) Virulence factor TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS (McCormick et al., 2001). 11179302
4274 sagA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 900920 15674789 SPy_0738 NP_268963.1 streptolysin S associated protein Virulence factor MUTATION: sagA mutant is attenuated in mice (Betschel et al., 1998). 9529097
4275 lsp from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 900995 15674864 SPy_0826 NP_269038.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4276 dltA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901401 15675261 SPy_1312 NP_269435.1 D-alanine--poly(phosphoribitol) ligase subunit 1 Virulence factor MUTATION: dltA mutant was diminished in its ability to adhere to and invade cultured human pharyngeal epithelial cells (Kristian et al., 2005). 16166534
4277 scpA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901674 15675796 SPy_2010 NP_269970.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4278 sic Streptococcus pyogenes M1 GAS 901676 15675798 SPy_2016 NP_269972.1 inhibitor of complement-mediated lysis Virulence factor MUTATION: sic mutant was phagocytosed and killed by human polymorphonuclear leukocytes significantly better than the wild-type strain (Hoe et al., 2002). 12032337
4279 emm1 Streptococcus pyogenes M1 GAS 901677 15675799 SPy_2018 NP_269973.1 M protein type 1 Virulence factor MUTATION: emm1 mutant had greatly reduced invasion of HeLa cells (Dombek et al., 1999). 10048029
4280 mga from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901678 15675800 SPy_2019 NP_269974.1 M protein trans-acting positive regulator Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008). 18588968
4281 speB from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901690 15675811 SPy_2039 NP_269985.1 pyrogenic exotoxin B Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains (Chiang-Ni and Wu, 2008). 18796357
4282 gidA from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 901831 15675920 SPy_2185 NP_270094.1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Virulence factor MUTATION: gidA mutant is highly attenuated in the murine ulcer model of soft tissue infection (Cho and Caparon, 2008). 18426891
4283 SPy_1633 Streptococcus pyogenes M1 GAS 901885 15675508 SPy_1633 AE004092 NP_269682 hypothetical protein Virulence factor MUTATION: SPy_1633 (cvfA) mutant is attenuated in mice (Kang et al., 2010). 20385762
4284 SPy_1718 Streptococcus pyogenes M1 GAS 901955 15675569 SPy_1718 AE004092 NP_269743 putative esterase Virulence factor MUTATION: SPy_1718 (sse) mutant is attenuated in mice (Zhu et al., 2009). 19805529
4285 fba from Streptococcus pyogenes M1 GAS Streptococcus pyogenes M1 GAS 902096 15675705 SPy_1889 NP_269879.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001). 11679068
4313 spyM18_1239 Streptococcus pyogenes MGAS8232 993646 19746214 spyM18_1239 NP_607350.1 putative exotoxin precursor (SpeM) Virulence factor TOXIN: Purified SpeM is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeM was lethal in one model of streptococcal toxic shock (Smoot et al., 2002). 12438391
4314 spyM18_1238 Streptococcus pyogenes MGAS8232 994087 19746213 spyM18_1238 NP_607349.1 putative exotoxin precursor (SpeL) Virulence factor TOXIN: Purified SpeL is pyrogenic and mitogenic for rabbit splenocytes and human peripheral blood mononuclear cells in picogram amounts. SpeL was lethal in two animal models of streptococcal toxic shock (Smoot et al., 2002). 12438391
4315 mga from Streptococcus pyogenes MGAS8232 Streptococcus pyogenes MGAS8232 994370 19746912 spyM18_2077 NP_608048.1 positive regulatory protein Mga Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008). 18588968
4316 scpA from Streptococcus pyogenes MGAS8232 Streptococcus pyogenes MGAS8232 994764 19746910 spyM18_2074 NP_608046.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4317 speA Streptococcus pyogenes MGAS8232 995014 19745506 spyM18_0393 NP_606642.1 exotoxin type A precursor Virulence factor TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits (Lee and Schlievert, 1989). 2504778
4318 sagA from Streptococcus pyogenes MGAS8232 Streptococcus pyogenes MGAS8232 995250 19745828 spyM18_0799 NP_606964.1 streptolysin S associated protein Virulence factor MUTATION: sagA mutant is attenuated in mice (Betschel et al., 1998). 9529097
4322 SpyM3_0013 Streptococcus pyogenes MGAS315 1008327 21909549 SpyM3_0013 NP_663817.1 putative amino acid permease Virulence factor MUTATION: SpyM3_0013 mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4323 SpyM3_0104 Streptococcus pyogenes MGAS315 1008418 21909640 SpyM3_0104 AE014074 NP_663908 protein F2 like fibronectin-binding protein Virulence factor MUTATION: F2 like fibronectin-binding protein mutant had attenuated attachment to to HEp-2 epithelial cells (Kreikemeyer et al., 2004). 14749329
4324 slo Streptococcus pyogenes MGAS315 1008444 21909666 SpyM3_0130 NP_663934.1 streptolysin O Virulence factor MUTATION: slo mutant was attenuated in mice (Limbago et al., 2000). 11035749
4325 atmB Streptococcus pyogenes MGAS315 1008547 21909769 SpyM3_0233 NP_664037.1 ABC transporter substrate-binding protein Virulence factor MUTATION: atmB mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4326 SpyM3_0385 Streptococcus pyogenes MGAS315 1008699 21909921 SpyM3_0385 AE014074 NP_664189 UDP-glucose 6-dehydrogenase Virulence factor MUTATION: SpyM3_0385 mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4327 SpyM3_0386 Streptococcus pyogenes MGAS315 1008700 21909922 SpyM3_0386 AE014074 NP_664190 putative efflux protein Virulence factor MUTATION: SpyM3_0386 mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4328 lsp from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1008870 21910092 SpyM3_0556 NP_664360.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4329 salT Streptococcus pyogenes MGAS315 1009964 21911185 SpyM3_1649 NP_665453.1 putative salivaricin A modification enzyme Virulence factor MUTATION: salT mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4330 scpA from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1010041 21911262 SpyM3_1726 NP_665530.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4331 emm3 Streptococcus pyogenes MGAS315 1010042 21911263 SpyM3_1727 NP_665531.1 antiphagocytic M protein, type 3 Virulence factor MUTATION: emm3 mutant has reduced adherence to and internalization into HEp-2 cells compared to the wild type (Eyal et al., 2003). 14522456
4332 mga from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1010043 21911264 SpyM3_1728 NP_665532.1 M protein trans-acting positive regulator, multi-gene activator Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008). 18588968
4333 speB from Streptococcus pyogenes MGAS315 Streptococcus pyogenes MGAS315 1010057 21911278 SpyM3_1742 NP_665546.1 pyrogenic exotoxin B Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains (Chiang-Ni and Wu, 2008). 18796357
4334 SpyM3_1795 Streptococcus pyogenes MGAS315 1010110 21911331 SpyM3_1795 AE014074 NP_665599 hypothetical protein Virulence factor MUTATION: SpyM3_1795 mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4335 hasA Streptococcus pyogenes MGAS315 1010166 21911387 SpyM3_1851 NP_665655.1 hyaluronan synthase Virulence factor MUTATION: hasA mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4348 SPs0560 Streptococcus pyogenes SSI-1 1065796 28895472 SPs0560 NP_801822.1 SpeA precursor Virulence factor TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits (Lee and Schlievert, 1989). 2504778
4349 M6_Spy0741 Streptococcus pyogenes MGAS10394 2941480 50914087 M6_Spy0741 YP_060059.1 SpeA variant Virulence factor TOXIN: SpeA causes pyrexia, hypotension and lethality when administered to rabbits (Lee and Schlievert, 1989). 2504778
4350 speJ from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3573258 71903011 M28_Spy0345 YP_279814.1 exotoxin type J precursor Virulence factor TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS (McCormick et al., 2001). 11179302
4351 scpA from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3574429 71904362 M28_Spy1700 YP_281165.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4352 mga from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3574433 71904366 M28_Spy1704 YP_281169.1 M protein trans-acting positive regulator (Mga) Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008). 18588968
4353 lsp from Streptococcus pyogenes MGAS6180 Streptococcus pyogenes MGAS6180 3574788 71903283 M28_Spy0617 YP_280086.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4354 gidA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571047 71911651 M5005_Spy_1838 YP_283201.1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Virulence factor MUTATION: gidA mutant is highly attenuated in the murine ulcer model of soft tissue infection (Cho and Caparon, 2008). 18426891
4355 speB from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571136 71911548 M5005_Spy_1735 YP_283098.1 streptococcal pyrogenic exotoxin B Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains (Chiang-Ni and Wu, 2008). 18796357
4356 scpA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571155 71911528 M5005_Spy_1715 YP_283078.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4357 mga from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571160 71911533 M5005_Spy_1720 YP_283083.1 trans-acting positive regulator Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008). 18588968
4358 smeZ Streptococcus pyogenes MGAS5005 3571180 71911515 M5005_Spy_1702 YP_283065.1 mitogenic exotoxin Z Virulence factor MUTATION: smeZ mutant is attenuated in zebrafish (Kizy and Neely, 2009). 19223485
4359 fba from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571297 71911420 M5005_Spy_1607 YP_282970.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001). 11679068
4360 M5005_Spy_1305 Streptococcus pyogenes MGAS5005 3571619 71911118 M5005_Spy_1305 YP_282668.1 two-component response regulator Virulence factor MUTATION: In a murine skin infection model, an insertion mutation in the response regulator gene, trxR (M5005_Spy_1305), led to a significant reduction in lesion size, lesion severity, and lethality (Leday et al., 2008). 18678666
4361 grab Streptococcus pyogenes MGAS5005 3571808 71910919 M5005_Spy_1106 YP_282469.1 protein G-related alpha 2M-binding protein Virulence factor MUTATION: grab mutant is attenuated in mice when injected intraperitoneally (Rasmussen et al., 1999). 10336419
4362 dltA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3571853 71910886 M5005_Spy_1073 YP_282436.1 D-alanine--poly(phosphoribitol) ligase subunit 1 Virulence factor MUTATION: dltA mutant was diminished in its ability to adhere to and invade cultured human pharyngeal epithelial cells (Kristian et al., 2005). 16166534
4363 lsp from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3572266 71910450 M5005_Spy_0637 YP_282000.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4364 sagA from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3572347 71910375 M5005_Spy_0562 YP_281925.1 streptolysin S precursor Virulence factor MUTATION: sagA mutant is attenuated in mice (Betschel et al., 1998). 9529097
4365 ccpA Streptococcus pyogenes MGAS5005 3572479 71910237 M5005_Spy_0424 YP_281787.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice (Shelburne et al., 2010). 20333240
4366 speJ from Streptococcus pyogenes MGAS5005 Streptococcus pyogenes MGAS5005 3572567 71910169 M5005_Spy_0356 YP_281719.1 exotoxin type J precursor Virulence factor TOXIN: rSPE J stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, induced fevers in rabbits, and was lethal in two models of STSS (McCormick et al., 2001). 11179302
4367 covS Streptococcus pyogenes MGAS5005 3572612 71910097 M5005_Spy_0283 YP_281647.1 transmembrane histidine kinase Virulence factor MUTATION: covS mutant has reduced capacity to bind to epithelial cell layers (Hollands et al., 2010). 20507231
4368 oppA Streptococcus pyogenes MGAS5005 3572677 71910063 M5005_Spy_0249 YP_281613.1 oligopeptide-binding protein Virulence factor MUTATION: oppA mutant caused less mortality and tissue damage than the wild-type strain when inoculated into BALB/c mice via an air pouch (Wang et al., 2005). 15845494
4369 perR Streptococcus pyogenes MGAS5005 3572745 71909975 M5005_Spy_0161 YP_281525.1 ferric uptake regulation protein Virulence factor MUTATION: perR mutant is attenuated in mouse air sac model (Ricci et al., 2002). 12183543
4389 lsp from Streptococcus pyogenes MGAS9429 Streptococcus pyogenes MGAS9429 4060566 94988323 MGAS9429_Spy0692 YP_596424.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4390 scpA from Streptococcus pyogenes MGAS9429 Streptococcus pyogenes MGAS9429 4061049 94989350 MGAS9429_Spy1720 YP_597451.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4391 scpA from Streptococcus pyogenes MGAS10270 Streptococcus pyogenes MGAS10270 4063044 94991291 MGAS10270_Spy1782 YP_599391.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4392 lsp from Streptococcus pyogenes MGAS10270 Streptococcus pyogenes MGAS10270 4063392 94990202 MGAS10270_Spy0693 YP_598302.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4393 fba from Streptococcus pyogenes MGAS10270 Streptococcus pyogenes MGAS10270 4064175 94991185 MGAS10270_Spy1676 YP_599285.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001). 11679068
4394 scpA from Streptococcus pyogenes MGAS2096 Streptococcus pyogenes MGAS2096 4064563 94993241 MGAS2096_Spy1744 YP_601340.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4395 lsp from Streptococcus pyogenes MGAS2096 Streptococcus pyogenes MGAS2096 4065311 94992200 MGAS2096_Spy0703 YP_600299.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4396 fba from Streptococcus pyogenes MGAS10750 Streptococcus pyogenes MGAS10750 4066760 94995059 MGAS10750_Spy1663 YP_603157.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001). 11679068
4397 scpA from Streptococcus pyogenes MGAS10750 Streptococcus pyogenes MGAS10750 4066822 94995203 MGAS10750_Spy1807 YP_603301.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4398 lsp from Streptococcus pyogenes MGAS10750 Streptococcus pyogenes MGAS10750 4067861 94994122 MGAS10750_Spy0726 YP_602220.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4429 lsp from Streptococcus pyogenes str. Manfredo Streptococcus pyogenes str. Manfredo 4963525 139473996 SpyM51170 YP_001128712.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4430 scpA from Streptococcus pyogenes str. Manfredo Streptococcus pyogenes str. Manfredo 4964259 139474482 SpyM51681 YP_001129198.1 C5A peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4438 fba from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985084 209560042 Spy49_1559c YP_002286514.1 fructose-bisphosphate aldolase Virulence factor MUTATION: fba mutant showed diminished invasive capabilities to HEp-2 cells and low mortality in mice following skin infection (Terao et al., 2001). 11679068
4439 ska Streptococcus pyogenes NZ131 6985239 209560110 Spy49_1630 YP_002286582.1 Streptokinase Virulence factor MUTATION: ska mutant was attenuated in mouse acute poststreptococcal glomerulonephritis model (Nordstrand et al., 2000). 10678902
4440 scpA from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985276 209560146 Spy49_1669c YP_002286618.1 C5a peptidase precursor Virulence factor MUTATION: scpA mutant is attenuated in mouse pneumonia model (Husmann et al., 1997). 9119483
4441 mga from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985280 209560150 Spy49_1673c YP_002286622.1 M protein trans-acting positive regulator (Mga) Virulence factor MUTATION: mga mutant is attenuated in a humanized mouse model for superficial skin infection (Luo et al., 2008). 18588968
4442 speB from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985296 209560166 Spy49_1690c YP_002286638.1 Strepotococcal cysteine protease (Streptopain) / Streptococcal pyrogenic exotoxin B (SpeB) Virulence factor MUTATION: Mice infected by M1, M3 and M49 speB mutants, through air pouch or intraperitoneal challenge, showed less mortality compared with that of the wild-type strains (Chiang-Ni and Wu, 2008). 18796357
4443 sagA from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985582 209559117 Spy49_0568 YP_002285589.1 Streptolysin S associated protein (SagA) Virulence factor MUTATION: sagA mutant is attenuated in mice (Eberhard et al., 2001). 11801184
4444 lsp from Streptococcus pyogenes NZ131 Streptococcus pyogenes NZ131 6985658 209559191 Spy49_0647 YP_002285663.1 lipoprotein signal peptidase Virulence factor MUTATION: lsp mutant is attenuated in a murine model of soft tissue infection (Weston et al., 2009). 19398546
4882 hyaluronic acid capsule Streptococcus pyogenes Virulence factor MUTATION: A mutant acapsular strain TX72 (with a mutation in hasA) was avirulent in mice and sensitive to phagocytic killing in vitro (Wessels et al., 1994). 8300204