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Found 120 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4583 ACE2 Candida albicans SC5314 3645995 68487492 CaO19.13543 AACQ01000160 XP_712367 Virulence factor MUTATION: ace2 mutant is virulent in a mouse model (Kelly et al., 2004).
15255906
4585 ADE2 Candida albicans ATCC 32354 1658378 1658379 AAC49755.1 phosphoribosylaminoimidazole carboxylase Virulence factor MUTATION: ade2 mutant is avirulent in immunosuppressed mice (Donovan et al., 2001).
11254618
4586 ALO1 Candida albicans SC5314 3638983 68473015 CaO19.7551 AACQ01000032 XP_719313 Virulence factor MUTATION: alo1 mutant is attenuated in mice (Huh et al., 2001).
11349062
4587 ALS1 Candida albicans 7687905 agglutinin-like protein Virulence factor MUTATION: als1p mutant is attenuated in mice (Fu et al., 2002).
MUTATION: als1p mutant has attenuated destruction of epithelial destruction in buccal reconstituted human epithelium (RHE) model of oral canididiasis (Zhao et al., 2004).
11967069 15256583
4588 ALS3 Candida albicans 29373982 29373983 AAO72959.1 agglutinin-like sequence 3 Virulence factor MUTATION: als3/als3 mutant was defective in adhesion to both human umbilical vein endothelial cells (HUVEC) and buccal epithelial cells (BEC) (Kelly et al., 2004).
15255906
4589 ASH1 Candida albicans SC5314 3641249 68477667 CaO19.5343 AACQ01000059 XP_717146 Virulence factor MUTATION: ash1p mutant is attenuated for virulence in a mouse model of disseminated candidiasis (Inglis and Johnson, 2002).
12446785
4590 BGL2 Candida albicans 532775 532776 AAA21151.1 beta-1,3 glucan transferase Virulence factor MUTATION: BGL2 mutant is attenuated in mice (Sarthy et al., 1997).
9043114
4591 cahk1 Candida albicans 2961065 2961066 AAC39451.1 histidine kinase 1 Virulence factor MUTATION: cahk1 mutant is attenuated in mice (Calera et al., 1999).
10417206
4592 MNT1 Candida albicans SC5314 3636585 68468365 CaO19.1665 AACQ01000014 XP_721742 Virulence factor MUTATION: mnt1p mutant has reduced ability to adhere to human buccal epithelial cells and to rat vaginal epithelial cells, and is attenuated in guinea pig and mouse models of systemic candidosis (Buurman et al., 1998).
9636208
4593 CMP65 Candida albicans SC5314 3643971 68483450 CaO19.9345 AACQ01000105 XP_714381 Virulence factor MUTATION: camp65 mutants are attenuated in mice (Sandini et al., 2007).
17217426
4594 CaNAG1 Candida albicans 13702164 Virulence factor MUTATION: CaNAG1 is moderately attenuated in mice (Yamada-Okabe et al., 2001).
11298769
4595 CaNAG2 Candida albicans 13702150 13702151 BAB43813.1 Virulence factor MUTATION: CaNAG2 is markedly attenuated in mice (Yamada-Okabe et al., 2001).
11298769
4596 NAG3 Candida albicans SC5314 3646118 68487759 CaO19.9705 AACQ01000162 XP_712290 Virulence factor MUTATION: CaNAG3 mutant is attenuated in mice (Yamada-Okabe and Yamada-Okabe, 2002).
12076781
4597 NAG4 Candida albicans SC5314 3645978 68487473 CaO19.2160 AACQ01000158 XP_712435 Virulence factor MUTATION: CaNAG4 mutant is attenuated in mice (Yamada-Okabe and Yamada-Okabe, 2002).
12076781
4598 CaNAG5 Candida albicans 13702156 13702157 BAB43816.1 Virulence factor MUTATION: CaNAG5 is markedly attenuated in mice (Yamada-Okabe et al., 2001).
11298769
4599 NAG6 Candida albicans SC5314 3645961 68487455 CaO19.2151 AACQ01000158 XP_712426 Virulence factor MUTATION: CaNAG6 mutant is attenuated in mice (Yamada-Okabe and Yamada-Okabe, 2002).
12076781
4600 CaNIK1 Candida albicans 2911163 2911164 BAA24952.1 Virulence factor MUTATION: CaNik1 mutant is attenuated in mice (Yamada-Okabe et al., 1999).
10572127
4601 NRG1 Candida albicans ATCC10261 12958591 12958592 AAK09366.1 Nrg1 Virulence factor MUTATION: Inactivation of CaNrg1 causes attenuated virulence in mice (Murad et al., 2001).
11532938
4602 CaRAS1 Candida albicans wo1 6103364 6103365 AAF03566.1 Ras homolog type A Virulence factor MUTATION: CaRAS1 mutant is less resistant to phagocytosis and has reduced virulence in mice (Leberer et al., 2001).
11722734
4603 CaSLN1 Candida albicans 2911161 2911162 BAA24951.1 Virulence factor MUTATION: CaSLN1 mutant is attenuated in mice (Yamada-Okabe et al., 1999).
10572127
4604 Cat1 Candida albicans ATCC 10261 3097875 3097876 AAC39448.1 catalase Virulence factor MUTATION: CAT1 null mutant is attenuated in mice for an intravenous infection model of disseminated candidiasis (Wysong et al., 1998).
9573075
4605 TEC1 Candida albicans SC5314 3635261 68465521 CaO19.5908 AACQ01000003 XP_723122 Virulence factor MUTATION: The deletion of the CaTEC1 gene attenuates virulence of C. albicans in a systemic model of murine candidiasis (Schweizer et al., 2000).
11069668
4606 TPS2 Candida albicans SC5314 3636892 68468955 CaO19.3038 AACQ01000017 XP_721536 Virulence factor MUTATION: CaTPS2 mutant is attenuated in a mouse model of systemic infection (Van et al., 2002).
11895938
4607 CDC10 Candida albicans SC5314 3640905 68477055 CaO19.8183 AACQ01000055 XP_717505 Virulence factor MUTATION: cdc10 mutant is attenuated in mice (Warenda et al., 2003).
12819094
4608 CDC11 Candida albicans SC5314 3647888 68491366 CaO19.5691 AACQ01000261 XP_710520 Virulence factor MUTATION: cdc11 mutant is attenuated in mice (Warenda et al., 2003).
12819094
4609 CDC24 Candida albicans 28192689 28192690 AAO25556.1 guanine nucleotide exchange factor Cdc24 Virulence factor MUTATION: cdc24 mutant is avirulent in mice (Bassilana et al., 2003).
12582118
4610 ERK1 Candida albicans SC5314 3642789 68481001 CaO19.2886 AACQ01000083 XP_715542 Virulence factor MUTATION: disruption of the CEK1 gene adversely affects the growth of serum-induced mycelial colonies and attenuates virulence in a mouse model for systemic candidiasis (Csank et al., 1998).
9596738
4615 chik1 Candida albicans ATCC366 3243088 3243089 AAC23929.1 histidine kinase Virulence factor MUTATION: Cos-1(chik1) mutant had sgnificantly reduced virulence in a systemic murine model of candidosis (Selitrennikoff et al., 2001).
11270409
4616 CACHS3 Candida albicans IFO1060 218361 218362 BAA02707.1 chitin synthase III Virulence factor MUTATION: CHS3 mutant is significantly less virulent than the parental strain in both immunocompetent and immunosuppressed mice (Bulawa et al., 1995).
7479842
4617 CHS7 Candida albicans SC5314 3639789 68474685 CaO19.9980 AACQ01000040 XP_718550 Virulence factor MUTATION: chs7 mutant had reduced virulence and a high clearance rate in mice (Sanz et al., 2005).
16079341
4618 CLA4 Candida albicans 2351701 2351702 AAB68613.1 CLA4 protein kinase homolog Virulence factor MUTATION: The gene deletions of CLA4 reduced colonization of the kidneys in infected mice and suppressed C. albicans virulence in the mouse model (Leberer et al., 1997).
9259554
4619 CNA1 Candida albicans SC5314 3639328 68473784 CaO19.6033 AACQ01000035 XP_718995 Virulence factor MUTATION: cmp1 (CNA1)mutant is strongly attenuated in mice (Bader et al., 2003).

12933882
4620 CNA1 Candida albicans SC5314 3639406 68473993 CaO19.13454 AACQ01000036 XP_718893 Virulence factor MUTATION: CNA mutant is attenuated in mice (Sanglard et al., 2003).
12753189
4621 CNB1 Candida albicans SC5314 3636332 68467839 CaO19.11492 AACQ01000012 XP_722078 Virulence factor MUTATION: cnb1 mutants are attenuated in mice (Blankenship et al., 2003).
12796287
4622 CPP1 Candida albicans 349178 2947041 AAC05307.1 protein-tyrosine phosphatase Virulence factor MUTATION: CPP1 mutant is attenauted in a systemic mouse model (Csank et al., 1997).
9398674
4623 UTR2 Candida albicans SC5314 3636747 68468620 CaO19.9240 AACQ01000013 XP_721629 Virulence factor MUTATION: csf4 (UTR2) mutant has reduction in adherence to mammalian cells and attenuated virulence in an immunocompetent mouse model of disseminated candidiasis (Alberti-Segui et al., 2004).
15042589
4624 CSH1 33090238 33090239 AAP93915.1 cell surface hydrophobicity-associated protein Virulence factor MUTATION: Csh1 is attenuated in mucosal colonization in a vaginal infection model in mice (Singleton et al., 2005).
15766793
4625 SHR3 Candida albicans SC5314 3646776 68489085 CaO19.10874 AACQ01000190 XP_711608 Virulence factor MUTATION: csh3 (SHR3) mutant is attenuated is avirulent in mice (Martínez and Ljungdahl, 2004).
14756779
4626 CSP37 Candida albicans ATCC 26555 2149593 2149594 AAB66368.1 putative membrane protein Virulence factor MUTATION: Csp37 mutant is attenuated in mice (Sentandreu et al., 1997).
9244249
4627 CST20 Candida albicans SC5314 3637661 68470348 CaO19.11717 AACQ01000021 XP_720678 Virulence factor MUTATION: CST20 mutant cells were less virulent in a mouse model for systemic candidiasis (Leberer et al., 1996).
8917571
4628 DAC1 Candida albicans SC 5314 6137104 6137106 AAF04335.1 N-acetyl-glucosamine-6-phosphate deacetylase Virulence factor MUTATION: a DAC1/NAG1/HXK1 mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro (Singh et al., 2001).
11705974
4629 ECM33 Candida albicans CAF2 53987032 53987033 AAV27296.1 GPI protein Virulence factor MUTATION: ecm33 mutant is avirulent in mice (Martinez-Lopez et al., 2004).
15470113
4630 EFG Candida albicans ATCC10231 6468469 832907 CAA83640.1 putative transcription factor Virulence factor MUTATION: deltaefg1 mutant has reduced capacity to invade and injure endothelial cells (Phan et al., 2000).
10816502
4631 FKH2 Candida albicans SC5314 3640536 68476229 CaO19.5389 AACQ01000050 XP_717764 Virulence factor MUTATION: fkh2 mutant are unable to damage human epithelial or endothelial cells in vitro (Bensen et al., 2002).
12455696
4632 GAT1 Candida albicans 31559063 31559064 AAP50501.1 nitrogen regulatory GATA-factor Virulence factor MUTATION: gat1 mutants are highly attenuated in a murine model of disseminated candidiasis (Limjindaporn et al., 2003).
14617156
4633 GNA1 Candida albicans SC5314 3637397 68469902 CaO19.837 AACQ01000019 XP_720961 GTP cyclohydrolase subunit MoaC Virulence factor MUTATION: gna1 null mutant is significantly attenuated in mice (Mio et al., 2000).
10878139
4634 GPI7 Candida albicans SC5314 3647663 68490911 CaO19.11547 AACQ01000242 XP_710743 Virulence factor MUTATION: gpi7 mutant is attenuated for virulence in mice and has reduced survival in the gastrointestinal environment of mice (Richard et al., 2002).
11994163
4635 CLN3 Candida albicans SC5314 3639349 68473774 CaO19.6028 AACQ01000035 XP_718990 Virulence factor MUTATION: hgc1 (CLN3) mutant is has markedly reduced virulence in the kidneys of systemically infected mice (Zheng et al., 2004).
15071502
4636 HOG1 Candida albicans SC5314 3637270 68469771 CaO19.8514 AACQ01000018 XP_721137 Virulence factor MUTATION: hog1 mutant is attenuated in mice (Alonso-Monge et al., 1999).
10322006
4637 HWP1 Candida albicans SC5314 4028879 1915979 AAC96368.1 hyphal wall protein 1 Virulence factor MUTATION: Candida albicans strains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice (Staab et al., 1999).
10066176
4638 NAG5 Candida albicans SC5314 3646114 68487751 CaO19.9701 AACQ01000162 XP_712286 Virulence factor MUTATION: a DAC1/NAG1/HXK1(NAG5) mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro (Singh et al., 2001).
11705974
4639 ICL1 Candida albicans SC5314 3646146 68487782 CaO19.6844 AACQ01000163 XP_712232 Virulence factor MUTATION: Candida albicans mutants lacking ICL1 are markedly less virulent in mice than the wild type (Lorenz and Fink, 2001).
11452311
4640 INT1 Candida albicans SC5314 3637595 68470378 CaO19.11733 AACQ01000021 XP_720693 Virulence factor MUTATION: disruption of INT1 gene in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice (Gale et al., 1998).
9478896
4641 IRO1 Candida albicans SC5314 3636648 68468453 CaO19.1715 AACQ01000013 XP_721786 Virulence factor MUTATION: IRO1 mutant is attenuated in mice (Chibana et al., 2005).
16237272
4642 irs4 Candida albicans SC5314 3645650 68486800 CaO19.6953 AACQ01000148 XP_712754 Virulence factor MUTATION: an irs4 null mutant strain was associated with attenuated mortality, diminished tissue burdens, less extensive infections, impaired C. albicans hyphal formation and decreased kidney damage in mice (Badrane et al., 2005).
16151204
4643 ker1 Candida albicans SC5314 3638466 68472127 CaO19.6763 AACQ01000029 XP_719859 Virulence factor MUTATION: ker1 mutant had attenuated virulence in systemic mouse infections (Galán et al., 2004).
15289560
4644 Kex2 Candida albicans WO-1 2511731 2511732 AAB80929.1 proteinase Virulence factor MUTATION: kex2/kex2 mutants are highly attenuated in a mouse systemic infection model and persist within cultured macrophages for at least 24 h without causing damage (Newport et al., 2003).
12419804
4645 GPT1 Candida albicans SC5314 3638247 68471625 CaO19.7922 AACQ01000026 XP_720119 Virulence factor MUTATION: C. albicans KRE5 homozygous mutant strains exhibit a 50% reduction in adhesion to human epithelial cells and are completely avirulent in a mouse model of systemic infection (Herrero et al., 2004).
15590817
4646 LIG4 Candida albicans SC5314 3642986 68481400 CaO19.5798 AACQ01000087 XP_715339 Virulence factor MUTATION: deletion of one or both copies of LIG4 resulted in attenuation of virulence in a murine model of candidiasis (Andaluz et al., 2001).
11119499
4647 MAD2 Candida albicans SC5314 3644665 68484757 CaO19.8642 AACQ01000120 XP_713690 Virulence factor MUTATION: mad2 mutant is attenuated in mice (Bai et al., 2002).
12100546
4648 MDR Candida albicans B792 2516 2517 CAA37820.1 Virulence factor MUTATION: CaMDR1 mutant is attenuated in virulence in mouse kidneys (Becker et al., 1995).
7591094
4649 MDS3 Candida albicans BWP17 27413016 27413017 AAN77869.1 Mds3p Virulence factor MUTATION: mds3 mutant is attenuated in mice (Davis et al., 2002).
12524333
4651 SUR1 Candida albicans SC5314 3644089 68483590 CaO19.4077 AACQ01000110 XP_714248 Virulence factor MUTATION: mit1(SUR1) mutant was less virulent during both the acute and chronic phases of systemic infection in mice (Mille et al., 2004).
15347680
4652 MKC1 Candida albicans 1001 (ATCC 64385) 619449 619450 CAA54129.1 MAP kinase Mkc1 Virulence factor MUTATION: MKC1 mutant is attenuated in mice (Diez-Orejas et al., 1997).
9009353
4653 MLT1 Candida albicans SS 19549336 19549337 AAD51594.2 MRP-like transporter Virulence factor MUTATION: MLT1 mutant is attenuated in a mouse peritonitis model (Theiss et al., 2002).
11929516
4654 mnt2 Candida albicans Cai-4 1359535 1359536 CAA61538.1 putative mannosyl transferase Virulence factor MUTATION: mnt2 mutant is has reduced adherence to human buccal epithelial cells (Munro et al., 2005).
15519997
4655 NAG1 Candida albicans SC5314 3646116 6137104 68487755 CaO19.9703 AACQ01000162 XP_712288 N-acetyl-glucosamine-6-phosphate deacetylase Virulence factor MUTATION: a DAC1/NAG1/HXK1 mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro (Singh et al., 2001).
11705974
4656 NOT4 Candida albicans SC5314 28373259 28373260 AAF66693.2 NOT4p Virulence factor MUTATION: not4 mutant is attenuated in mice (Krueger et al., 2004).
14702416
4657 NOT5 Candida albicans SC5314 3640763 68476703 CaO19.5107 AACQ01000053 XP_717644 Virulence factor MUTATION: NOT5 mutant had reduced adherence to epithelial cells and has attenuated virulence in mice (Cheng et al., 2003).
14500538
4658 PDE2 Candida albicans SC5314 3636877 68468825 CaO19.2972 AACQ01000017 XP_721471 Virulence factor MUTATION: pde2 mutant is attenuated in mice (Wilson et al., 2007).
17614954
4659 PHR1 Candida albicans SC5314 857671 857672 AAA68196.1 pH responsive protein Virulence factor MUTATION: phr1 mutant is attenuated in mice (Ghannoum et al., 1995).
7591097
4660 PLB1 Candida albicans SC5314 3169706 3445504 AAC61890.1 phospholipase B precursor Virulence factor MUTATION: Plb1 mutant is attenuated in mice (Mukherjee et al., 2001).
11535799
4661 SPO14 Candida albicans SC5314 3645329 68486156 CaO19.1161 AACQ01000137 XP_713028 Virulence factor MUTATION: pld1(SPO14) mutants are unable to survive in internal organs after intravenous challenge, and are not lethal for immunodeficient mice after oral challenge (Dolan et al., 2004).
15552646
4663 PMR1 Candida albicans SC5314 3638043 68471207 CaO19.7089 AACQ01000024 XP_720380 Virulence factor MUTATION: pmr1 mutant was severely attenuated in virulence in a murine model of systemic infection (Bates et al., 2005).
15843378
4664 PMT1 Candida albicans SC5314 3641393 68477979 CaO19.5171 AACQ01000060 XP_716993 Virulence factor MUTATION: Homozygous pmt1 mutants were avirulent in a mouse model of systemic infection, while heterozygous PMT1/pmt1 strains showed reduced virulence (Timpel et al., 1998).
9694829
4665 PMT2 Candida albicans SC5314 3638538 68472223 CaO19.6812 AACQ01000028 XP_719907 Virulence factor MUTATION: pmt2 mutant has attenuated virulence in a mouse model of hematogenously disseminated candidiasis (HDC) (Rouabhia et al., 2005).
16040968
4666 PMT4 Candida albicans SC5314 3644096 68483654 CaO19.4109 AACQ01000110 XP_714280 Virulence factor MUTATION: pmt4 mutant is attenuated in mice (Prill et al., 2005).
15659169
4667 pmt5 Candida albicans SC5314 3639011 68473011 CaO19.7549 AACQ01000032 XP_719311 Virulence factor MUTATION: pmt5 mutant was less virulent in engineered human oral mucosa (EHOM) and in a mouse model of hematogenously disseminated candidiasis (HDC) (Rouabhia et al., 2005).
16040968
4668 PMT6 Candida albicans 1006 6561138 6561139 AAF16867.1 protein mannosyltransferase Virulence factor MUTATION: pmt6 mutant has reduced adherence to endothelial cells and attenuated virulence in mice (Timpel et al., 2000).
10809683
4669 RBT1 Candida albicans 9963981 9963982 AAG09787.1 repressed by TUP1 protein 1 Virulence factor MUTATION: rbt1 mutant is attenuated in both a rabbit cornea model and a mouse systemic infection model (Braun et al., 2000).
10978273
4670 RBT4 Candida albicans 9963985 9963986 AAG09789.1 repressed by TUP1 protein 4 Virulence factor MUTATION: rbt4 mutant is attenuated in both a rabbit cornea model and a mouse systemic infection model (Braun et al., 2000).
10978273
4671 RHO1 Candida albicans SC5314 3642557 68480453 CaO19.10362 AACQ01000079 XP_715825 Virulence factor MUTATION: RHO1 mutant is unable to colonize murine kidneys and cause disease in mice (Smith et al., 2002).
12702298
4672 RIM101 Candida albicans SC5314 3643280 68482059 CaO19.7247 AACQ01000092 XP_715047 Virulence factor MUTATION: rim101 mutant is attenuated in a mouse model of hematogenously disseminated systemic candidiasis (Davis et al., 2000).
10992507
4673 RIM8 Candida albicans SC5314 3639342 68473896 CaO19.6091 AACQ01000036 XP_719051 Virulence factor MUTATION: rim8 mutant is attenuated in a mouse model of hematogenously disseminated systemic candidiasis (Davis et al., 2000).
10992507
4674 RSR1 Candida albicans B792 1203833 1203834 AAB81286.1 Rsr1p Virulence factor MUTATION: RSR1 mutant is attenuated in mice (Yaar et al., 1997).
9308185
4675 SAP1 Candida albicans SC5314 3640256 68475693 CaO19.5714 AACQ01000046 XP_718053 Virulence factor MUTATION: sap1 mutant is attenuated in mice and guinea pigs (Hube et al., 1997).
9284116
4676 SAP2 Candida albicans CAI4 20378981 20378982 AAM21050.1 secreted aspartic proteinase 2 Virulence factor MUTATION: sap2 mutant is attenuated in mice and guinea pigs (Hube et al., 1997).
9284116
4677 SAP3 Candida albicans SC5314 3635197 68465697 CaO19.6001 AACQ01000004 XP_723210 Virulence factor MUTATION: sap3 mutant is attenuated in mice and guinea pigs (Hube et al., 1997).
9284116
4678 SAP4 Candida albicans SC5314 3640365 68475830 CaO19.13139 AACQ01000046 XP_717988 Virulence factor MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice (Hube et al., 1997).
9284116
4679 SAP5 Candida albicans SC5314 3639268 68473645 CaO19.5585 AACQ01000034 XP_719147 Virulence factor MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice (Hube et al., 1997).
9284116
4680 SAP6 Candida albicans SC5314 3639229 68473561 CaO19.5542 AACQ01000034 XP_719105 Virulence factor MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice (Hube et al., 1997).
9284116
4681 SAP7 Candida albicans SC5314 3644735 68484925 CaO19.8376 AACQ01000123 XP_713601 Virulence factor MUTATION: sap7 mutant is attenuated in an intravenous model of systemic candidiasis in mice (Taylor et al., 2005).
16177393
4682 ARN1 Candida albicans SC5314 3642307 68479941 CaO19.2179 AACQ01000076 XP_716020 Virulence factor MUTATION: sit1(ARN1) mutant was defective in infection of a reconstituted human epithelium as a model for human oral mucosa (Heymann et al., 2002).
12183576
4683 SIT4 Candida albicans SC5314 3647982 68491579 CaO19.12667 AACQ01000273 XP_710419 Virulence factor MUTATION: sit4 mutant is attenuated in mice (Lee et al., 2004).
14731272
4684 SKN7 Candida albicans SC5314 3641499 68478255 CaO19.8586 AACQ01000062 XP_716869 Virulence factor MUTATION: skn7 mutant is mildly attenuated in mice (Singh et al., 2004).
15039366
4685 sod1 Candida albicans 3005096 3005097 AAC12872.1 Cu,Zn-superoxide dismutase Virulence factor MUTATION: sod1 mutant had increased susceptibility to macrophage attack and had attenuated virulence in mice (Hwang et al., 2002).
12427960
4686 SOD5 Candida albicans SC5314 3638702 68472625 CaO19.9607 AACQ01000030 XP_719631 Virulence factor MUTATION: sod5 mutant is attenuated in mice (Martchenko et al., 2004).
14617819
4687 SPA2 Candida albicans SC5314 3646770 68489072 CaO19.13719 AACQ01000192 XP_711649 Virulence factor MUTATION: spa2Delta exhibited no virulence in the mouse systemic candidiasis model (Zheng et al., 2003).
12940995
4688 SPT3 Candida albicans SC5314 3638977 68473155 CaO19.7622 AACQ01000032 XP_719383 Virulence factor MUTATION: spt3 mutant is avirulent in mice (Laprade et al., 2002).
12072450
4689 SSN6 Candida albicans ATCC10231 18767667 18767668 AAL54912.2 putative transcriptional repressor Virulence factor MUTATION: ssn6/ssn6 mutant is avirulent in mice (Hwang et al., 2003).
12581357
4690 CaTOP1 Candida albicans 1762119 topoisomerase I Virulence factor MUTATION: a single gene knockout TOP1 mutant is attenuated in mice (Jiang et al., 1997).
9043115
4691 TPK2 Candida albicans strain 1161 7578501 7578502 AAF64072.1 protein kinase A Virulence factor MUTATION: tpk2/tpk2 mutant has reduced capacity to invade and damage oral epithelial cells and is also attenuated in mice (Park et al., 2005).
15760450
4692 TPS1 Candida albicans SC5314 3646212 68487926 CaO19.13961 AACQ01000186 XP_712180 Virulence factor MUTATION: Mice inoculated with 10(6) CFU of the tps1/tps1 mutant did not show visible symptoms of infection 16 days after inoculation, while those similarly inoculated with wild-type cells were dead 12 days after inoculation (Zaragoza et al., 1998).
9683476
4693 TUP1 Candida albicans SC5314 3639369 68473930 CaO19.6109 AACQ01000035 XP_719068 Virulence factor MUTATION: tup1 mutant is significantly reduced in the ability to invade and injure endothelial cells (Phan et al., 2000).
10816502
4694 VMA7 Candida albicans SC5314 3637217 68469597 CaO19.8424 AACQ01000019 XP_721050 Virulence factor MUTATION: vma7 null mutant is avirulent in a mouse model of systemic candidiasis (Poltermann et al., 2005).
15870472
4695 VPS4 Candida albicans SC5314 3637703 68470797 CaO19.4339 AACQ01000022 XP_720644 Virulence factor MUTATION: vps4 mutant is greatly attenuated for virulence in a mouse model of disseminated candidiasis (Lee et al., 2009).
18814053
4696 YHB1 Candida albicans SC5314 3647353 68490250 CaO19.3707 AACQ01000217 XP_711046 Virulence factor MUTATION: CaYHB1 mutant is still lethal in mice but has reduced virulence compared to the wild type (Ullmann et al., 2004).
15189992
4697 YVH1 Candida albicans SC5314 3643218 68481871 CaO19.4401 AACQ01000091 XP_715177 Virulence factor MUTATION: yvh1 has attenuated virulence in mice (Hanaoka et al., 2005).
16000712
5134 UPC2 556911682 transcription factor Upc2 Virulence factor Deletion of the transcription factors UPC2 (involved in the control of ERG11) of Candida albicans results in the significant attenuation of virulence in mice, and had a negative impact on fitness, results in the epidemiology of antifungal resistance.(Lohberger et al., 2014) 24243794
5137 NCE102 Candida albicans SC5314 3635267 68465619 CaO19.5960 AACQ01000004 XP_723171 Virulence factor Nce102 is implicated in regulating membrane structure and function.The nce102 mutant decreased virulence in mice. The results showed that Nce102 involved in a regulate pathways that regulate morphogenesis and pathogenesis of C. albicans. (Douglas et al., 2013) 24281718
5139 MNN21 Candida albicans SC5314 3648131 68491898 CaO19.8625 AACQ01000293 XP_710268 Virulence factor In Candida albicans, the mannosyltransferase, Mnn2, gene family is comprised of six members (MNN2, MNN21, MNN22, MNN23, MNN24 and MNN26) .Deletion of all MNN2 gene family members increased the average survival of the moth larvae by 50%, and the sextuple mutant was attenuated in virulence with 100% of mice surviving infection with the sextuple mutant.(Hall et al., 2013) 23633946
5140 TOP2 Candida albicans SC5314 3642722 68480866 CaO19.10391 AACQ01000083 XP_715586 DNA topoisomerase II similar to S. cerevisiae TOP2 Virulence factor the TOP2 gene played an important role in pathogenicity of C.albicans. The absence of TOP2 gene increased hypha formation, proteinases and phospholipase secretory activities, and so increased pathogenicity of C. albicans. (Zheng and Yu, 2012) 22203422
5141 SPF1 Candida albicans SC5314 3646573 68488657 CaO19.30 AACQ01000181 XP_711837 potential ER membrane P-type ATPase Virulence factor Spf1is a putative ER-localized P-type calcium ATPase in C. albicans. Deletion of SPF1 severely attenuated the virulence of Candida albicans in the mouse model. In contrast with the wild-type, SPF1 mutant produced little biomass and is defective for invasion in mouse kidneys. (Yu et al., 2012) 22745267
5142 PGA13 Candida albicans _SC5314 Virulence factor PGA13 encoding a GPI protein in Candida albicans, which is highly up-regulated during cell wall regeneration in protoplasts. Compared to the parental strain, the homozygous pga13Δ mutant processed shorter and irregular hyphae. All pga13Δ mutants (homo-, heterozygous and reintegrant) showed a sharply attenuated virulence in a mouse model. Above all, these results indicated that Pga13 is a determinant of C. albicans pathogenicity.(Gelis et al., 2012) 22343036
5143 PGA29 Candida albicans Virulence factor The pga29 deletion mutant is less virulent, and infection of reconstituted human epithelium with the pga29 mutant results in a diminished induction of proinflammatory cytokines, such as GM-CSF, TNF, IL-6 and IL-8. Deletion of PGA29 leads to reduced tissue invasion of infected reconstituted human epithelium, and is slightly reduced in virulence in a mouse model of haematogenous disseminated candidiasis compared to the WT strain. (de et al., 2010) 20533408
5145 HSP104 Candida albicans SC5314 3642228 68479564 CaO19.13747 HC749752 XP_716146 Virulence factor the hsp104Δ mutation Decreased the virulence of Candida albicans in the Caenorhabditis elegans infection model. Worms infected with the homozygous mutant showed a clearly increase in survival relative to animals infected with the wild-type Candida albicans strains. The results show a temperature-independent role for Hsp104 in support of Candida albicans virulence, in addition to its key role in governing thermotolerance.(Fiori et al., 2012)
22635920
5146 DUR1,2 Candida albicans SC5314 3644729 68484977 CaO19.8402 AACQ01000123 XP_713627 Virulence factor A dur1,2Δ/dur1,2Δ mutant significantly decreased in virulence in a mouse model than the wild-type strain, showing significantly higher survival rate, better renal function, and decreased and less sustained fungal colonization in kidney and brain.(Navarathna et al., 2012) 23144764
5147 DUR31 Candida albicans SC5314 3644730 68484979 CaO19.8403 AACQ01000122 XP_713628 Virulence factor Homozygous knockout mutants with DUR31 in Candida albicans elicited the strongest reduction in pathogenicity which caused significantly less damage in human oral epithelium.(Mayer et al., 2012) 22438810
5148 SEF1 Candida albicans SC5314 3644909 68485287 CaO19.11237 AACQ01000127 XP_713477 Virulence factor Sef1 is critical for virulence and competitive infection in BALB/c mice. Sef1-deleted mutant was significantly outcompeted by wild type C. albicans in mouse kidneys.(Chen et al., 2011) 21843869
5149 HSF (CTA8) Candida albicans SC5314 3634947 68464767 CaO19.4775 AACQ01000001 XP_723461 Virulence factor C. albicans mutant which unable to activate Hsf1 gene display attenuated virulence in mice with systemic candidiasis. The HSF1 mutant displayed significantly reduced fungal burdens and outcome scores compared with the control strains.(Nicholls et al., 2011) 20817114