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Found 7 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4829 exgmp Leishmania mexicana MNYC/BZ/62/M379 12584592 GDP-mannose pyrophosphorylase Virulence factor MUTATION: GDPMP (exgmp) mutant is unable to infect macrophages or mice (Garami and Ilg, 2001).
4830 pmm Leishmania mexicana M379 15387672 phosphomannomutase Virulence factor MUTATION: PMM mutant is attenuated in mice and murine macrophages (Garami et al., 2001).
4831 Cht1 Leishmania mexicana M379 48375060 chitinase Virulence factor MUTATION: Overexpression of Cht1 in L. mexicana increased survival within sandfly vector, and more virulent infections in mice (Rogers et al., 2008).
5166 PMI Leishmania mexicana MHOM/GT/2001/U1103 13453593 401427037 LMXM_31_1580 FR799584 XP_003878002 Virulence factor The Delta lmexpmi mutant is attenuated in infections of macrophages in vitro and of mice. (Garami and Ilg, 2001) 11084042
5167 LMCPB 1730100 Cysteine proteinase B Virulence factor deletion of the entire multicopy cysteine protease B (CPB) gene array in L. mexicana is associated with decreased parasite virulence. (Buxbaum et al., 2003) 14500670
5169 ICP Leishmania mexicana MHOM/GT/2001/U1103 13448953 401423014 LMXM_24_1770 FR799577 XP_003875994 Virulence factor Null mutants grew normally in vitro, were as infective to macrophages in vitro as wild-type parasites, but had reduced infectivity to mice. Mutants re-expressing ICP from a single gene gave partial restoration of virulence in vivo, whereas mutants overexpressing ICP secreted the inhibitor and showed markedly reduced virulence in mice.(Besteiro et al., 2004)
5217 LmexCht1 Leishmania mexicana MHOM/GT/2001/U1103 13450317 401418548 LMXM_16_0790 FR799569 XP_003873765 Virulence factor the LmexCht1 transfectants survived significantly better in human macrophages and also produced significantly larger lesions in mice than control parasites.
(Joshi et al., 2005)