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Found 2 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
5022 RRVgp2 1489707 envelope glycoprotein E2 Virulence factor In day-old mice, RRV dE2,with a 21-nucleotide deletion in the gene coding for the envelope glycoprotein E2, induced less severe symptoms of hind leg paralysis than did RRV T48. In week-old mice, RRV dE2 induced no detectable symptoms even when injected at high doses. (Vrati et al., 1986) 3010551
5087 nsP1 25121492 nsP1 protein Virulence factor we identify two nonsynonymous nucleotide changes as sufficient for the attenuated phenotype. RRV T48 carrying the six nonsynonymous DC5692 nucleotide differences (RRV-T48-nsP1(6M)) was attenuated in both wild-type and Rag1(-/-) mice. Despite the attenuated phenotype, RRV T48 and RRV-T48-nsP1(6M) loads in tissues of wild-type and Rag1(-/-) mice were indistinguishable from 1 to 3 days postinoculation. RRV-T48-nsP1(6M) loads in skeletal muscle tissue, but not in other tissues, decreased dramatically by 5 days postinoculation in both wild-type and Rag1(-/-) mice, suggesting that the RRV-T48-nsP1(6M) mutant is more sensitive to innate antiviral effectors than RRV T48 in a tissue-specific manner.
(Stoermer et al., 2014)
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