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Found 4 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
5033 Ac-p74 Autographa californica nucleopolyhedrovirus 1403971 9627881 ACNVgp139 L22858 NP_054168 occlusion-derived virus envelope protein Virulence factor Ac228z, in which portions of adjacent carboxy-termini from peptides p74 and p10 were deleted, failed to kill larvae, whereas virus with deletions in p10 alone were as infectious to larvae as wild-type virus. (Kuzio et al., 1989) 2688302
5034 OpmnVgp129 Orgyia pseudotsugata MNPV 912086 9630067 OpmnVgp129 U75930 NP_046285 polyhedral envelope protein Virulence factor the absence of the polyhedral envelope and the efficient release of occluded virions are responsible for the increased virulence of polyhedral envelope negative mutants.
(Zuidema et al., 1989)
5080 pe38 Bombyx mori NPV 1488760 9630952 Bmnpvgp136 L33180 NP_047549 PE38 Virulence factor a knockout virus, Delta pe38-E9/E9, in which the pe38 open reading frame was replaced with that of the green fluorescent protein. We compared mutant and wild-type (WT) viral replication in insect cell culture and virulence in Heliothis virescens larvae. Compared to WT, Delta pe38-E9/E9 budded virus (BV) production was delayed by at least 3 h, and BV yields were reduced over 99%. Similarly, Delta pe38-E9/E9 DNA synthesis levels were greatly reduced relative to those of WT, but onset of DNA replication was the same for both viruses. In bioassays, nearly sevenfold more Delta pe38-E9/E9 virus than WT virus was required to achieve an LD(50) when administered orally, but not hemocoelically. (Milks et al., 2003) 12781710
5094 Orf_56 Bombyx mori NPV 1488687 9630875 Bmnpvgp059 JQ991009 NP_047472 AcMNPV orf68 Virulence factor Bioassay with Trichoplusia ni demonstrated that deletion of ac68 did not affect AcMNPV infectivity, but extended LT(50) to a longer value. Taken together, our results indicated that the deletion did not affect viral propagation both in vitro and in vivo, but deletion of the gene may affect the virulence in T. ni larvae. (Li et al., 2008) 18483845