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Found 6 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
5065 NL-S 1772821 1772822 AAB40136.1 virulence-associated protein Virulence factor the null mutant, E70/43, exhibited a marked reduction in pig virulence. In contrast to revertant or parental E70 where mortality was 100%, all E70/43-infected animals survived infection.
(Zsak et al., 1996)
8971015
5066 UK 2905984 2905985 AAC03759.1 virulence determinant Virulence factor Although deletion of UK did not affect the growth characteristics of the virus in macrophage cell cultures, deltaUK exhibited reduced virulence in infected pigs.
(Zsak et al., 1998)
9444996
5067 9GL 6759648 6759649 AAF27977.1 Za-9GL protein Virulence factor The Delta9GL virus was markedly attenuated in swine. In contrast to 9GL-R infection, where mortality was 100%, all Delta9GL-infected animals survived infection. With the exception of a transient fever response in some animals, Delta9GL-infected animals remained clinically normal and exhibited significant 100- to 10,000-fold reductions in viremia titers. All pigs previously infected with Delta9GL survived infection when subsequently challenged with a lethal dose of virulent parental MAL. Thus, ASFV 9GL gene deletion mutants may prove useful as live-attenuated ASF vaccines. (Lewis et al., 2000) 10627538
5068 MGF530 433103 433104 AAA50527.1 multigene family 530 protein Virulence factor both MS16 and BA71V had significant deletions in the region containing members of multigene family 360 (MGF 360) and MGF530. Deletion of this same region from highly pathogenic ASFV isolate Pr4 significantly reduced viral growth in macrophage cell cultures. Given that macrophages are the primary target cells of ASFV in swine, it is likely that these genes are also of significance for viral pathogenesis and virulence in domestic swine. Future studies will examine this possibility. (Zsak et al., 2001) 11238833
5069 MGF360 210601 both MS16 and BA71V had significant deletions in the region containing members of multigene family 360 (MGF 360) and MGF530. Deletion of this same region from highly pathogenic ASFV isolate Pr4 significantly reduced viral growth in macrophage cell cultures. Given that macrophages are the primary target cells of ASFV in swine, it is likely that these genes are also of significance for viral pathogenesis and virulence in domestic swine. Future studies will examine this possibility . (Zsak et al., 2001) 11238833
5075 K196R African swine fever virus 1488815 9628158 ASFVgp045 AF504896 NP_042744 thymidine kinase Virulence factor The Malawi TK deletion mutant showed reduced virulence for swine, producing transient fevers, lower viremia titers, and reduced mortality. In contrast, 100% mortality was observed for swine inoculated with the TK+ revertant virus. (Moore et al., 1998) 9811782