Search: for Help
Victors Home
Introduction
Statistics
News and Updates
Victors Query
Victors BLAST
Data Submission
Data Download
OHPI SPARQL Query
Documentation
FAQs
Disclaimer
Contact Us
UMMS Logo

Victors Search

Found 4 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
5231 bap A. baumannii strain 307-0294 159797905 159797906 EU117203 biofilm-associated protein Virulence factor
5233 pgaC 259020301 259020302 FJ866499 ACV90435.1 PgaC Virulence factor Deletion of the pga locus (the pgaABC genes) led to loss of the strong biofilm phenotype, which was restored by complementation (Choi et al., 2009).

pgaC is predicted to encode a 392-amino-acid N-glycosyltransferase that belongs to the glycosyltransferase 2 family. This family includes PgaC, BpsC, HmsR, and IcaA from E. coli, B. pertussis, Y. pestis, and S. aureus, respectively. A. baumannii PgaC shares 55% identity with E. coli PgaC, 47% identity with B. pertussis BpsC, and 55% identity with Y. pestis HmsR. In addition, the five amino acids that have been shown to be critical for the catalytic activity of glycosyltransferases are all conserved in PgaC (Asp112, Asp205, Gln241, Arg244, and Trp245) (Choi et al., 2009).
19633088
5234 pgaB 259020299 259020300 ACV90434 ACV90434.1 PgaB Virulence factor Deletion of the pga locus (the pgaABC genes) led to loss of the strong biofilm phenotype, which was restored by complementation (Choi et al., 2009).

pgaB encodes a predicted 510-amino-acid protein with a putative polysaccharide deacetylase domain. It shares 33%, 31%, and 37% identity with E. coli PgaB, Y. pestis HmsF, and B. pertussis BpsB, respectively. All these proteins have putative deacetylase activities. In Y. pestis, HmsF was isolated from the outer membrane by cellular fractionation. E. coli PgaB is predicted to be an outer membrane lipoprotein that, along with PgaA, is necessary for PNAG export (Choi et al., 2009).
19633088
5235 pgaA 259020297 259020298 ACV90433 ACV90433.1 PgaA Virulence factor Deletion of the pga locus (the pgaABC genes) led to loss of the strong biofilm phenotype, which was restored by complementation (Choi et al., 2009).
A. baumannii pgaA encodes a predicted 812-amino-acid outer membrane protein that shares 26% identity with E. coli PgaA, 23% identity with Y. pestis HmsH, and 25% identity with B. pertussis BpsA. In E. coli, PgaA contains a predicted porin domain that facilitates PNAG translocation across the outer membrane, as well as a superhelical periplasmic domain that is thought to play a role in protein-protein interactions. In Y. pestis HmsH has been demonstrated to be an outer membrane protein (Choi et al., 2009).
19633088