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Found 360 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
57 sigF from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 922492 15842877 MT3385 NP_337914.1 RNA polymerase sigma factor SigF Virulence factor MUTATION: sigF mutant is attenuated in mice (Geiman et al., 2004). 14977982
58 fbpA from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 922599 15843426 MT3911 NP_338463.1 esterase, putative, antigen 85-A Virulence factor MUTATION: fbpA mutant is attenuated in mice (Copenhaver et al., 2004). 15557632
59 panD from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 922795 15843213 MT3706.1 NP_338250.1 aspartate alpha-decarboxylase Virulence factor MUTATION: panCD mutant is attenuated in mice (Sambandamurthy et al., 2002). 12219086
60 sigH from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 922907 15842811 MT3320 NP_337848.1 RNA polymerase sigma factor RpoE Virulence factor MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice (Kaushal et al., 2002). 12060776
61 MT3523 Mycobacterium tuberculosis CDC1551 923111 15843010 MT3523 NP_338047.1 RNA polymerase sigma factor SigD Virulence factor MUTATION: sigD mutant is attenuated in human macrophages and mice (Calamita et al., 2005). 15659067
62 hspR from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 923545 15839739 MT0368 NP_334776.1 transcriptional regulator HspR Virulence factor MUTATION: hspR mutant is attenuated in mice (Stewart et al., 2001). 11385512
63 katG from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 923602 15841380 MT1959 NP_336417.1 catalase-peroxidase Virulence factor MUTATION: katG mutant is attenuated in mice and guinea pigs (Li et al., 1998). 9534978
64 sodC from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 923760 15839819 MT0447 NP_334856.1 superoxide dismutase Virulence factor MUTATION: sodC mutant is more susceptible to killing by activated murine macrophages than the wild type (Piddington et al., 2001). 11447176
65 mgtC from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 923776 15841281 MT1859 NP_336318.1 Mg2+ transport protein Virulence factor MUTATION: mgtC mutant is attenuated in human macrophages and mice (Buchmeier et al., 2000). 10760138
66 senX3 from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 923873 15839881 MT0509 NP_334918.1 sensor histidine kinase SenX3 Virulence factor MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003). 12777483
67 regX3 from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 923874 15839882 MT0510 NP_334919.1 DNA-binding response regulator RegX3 Virulence factor MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003). 12777483
68 proC from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 923905 15839892 MT0520 NP_334929.1 pyrroline-5-carboxylate reductase Virulence factor MUTATION: proC mutant is attenuated in mice (Smith et al., 2001). 11160012
69 trpD from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 924178 15841683 MT2248 NP_336720.1 anthranilate phosphoribosyltransferase Virulence factor MUTATION: trpD mutant is attenuated in mice (Smith et al., 2001). 11160012
70 lspA from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 924361 15841006 MT1591 NP_336043.1 lipoprotein signal peptidase Virulence factor MUTATION: lspA mutant is attenuated in mice (Rampini et al., 2008). 18832305
71 sigC from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 924601 15841558 MT2129 NP_336595.1 RNA polymerase sigma-70 factor, ECF subfamily Virulence factor MUTATION: sigC mutant is attenuated in mice (Sun et al., 2004). 15049808
72 sigE from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 924814 15840665 MT1259 NP_335702.1 RNA polymerase sigma factor SigE Virulence factor MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type (Manganelli et al., 2001). 11489128
73 leuD from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 925207 15842543 MT3065 NP_337580.1 isopropylmalate isomerase small subunit Virulence factor MUTATION: leuD mutant is attenuated in mice (Hondalus et al., 2000). 10768986
74 relA from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 925657 15842122 MT2660 NP_337159.1 GTP pyrophosphokinase Virulence factor MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism (Primm et al., 2000). 10940033
75 ahpC from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 925827 15841949 MT2503 NP_336986.1 alkyl hydroperoxide reductase C Virulence factor MUTATION: ahpC mutant has decreased survival in unactivated macrophages compared to the wild type (Master et al., 2002). 12368447
76 cysH from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 925884 15841906 MT2462 NP_336943.1 phosphoadenosine phosphosulfate reductase Virulence factor MUTATION: cysH mutant is attenuated in mice (Senaratne et al., 2006). 16553880
77 mma4 Mycobacterium tuberculosis CDC1551 925954 15840045 MT0670 NP_335082.1 methoxy mycolic acid synthase 4 Virulence factor MUTATION: mma4 mutant is attenuated in mice (Dubnau et al., 2000). 10844652
78 sigL from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 926053 15840142 MT0759 NP_335179.1 RNA polymerase sigma factor SigL Virulence factor MUTATION: sigL mutant is attenuated in mice (Hahn et al., 2005). 16199577
79 erp Mycobacterium tuberculosis CDC1551 926330 15843432 MT3917 NP_338469.1 exported repetitive protein Virulence factor MUTATION: erp mutant is attenuated in mice (Berthet et al., 1998). 9784137
80 panC from Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis CDC1551 926524 15843214 MT3707 NP_338251.1 pantoate--beta-alanine ligase Virulence factor MUTATION: panCD mutant is attenuated in mice (Sambandamurthy et al., 2002). 12219086
81 MT3491.1 Mycobacterium tuberculosis CDC1551 926547 15842976 MT3491.1 NP_338013.1 hypothetical protein Virulence factor MUTATION: MT3491.1 mutant is attenuated in survival within macrophages (Pethe et al., 2004). 15340136
82 mprA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885038 15608121 Rv0981 NP_215496.1 MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN) Virulence factor MUTATION: mprA mutant is attenuated in mice (Zahrt and Deretic, 2001). 11675502
83 dppD Mycobacterium tuberculosis H37Rv 885039 15610799 Rv3663c NP_218180.1 PROBABLE DIPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DPPD Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
84 PPE31 Mycobacterium tuberculosis H37Rv 885072 57116920 Rv1807 YP_177653.1 PPE FAMILY PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
85 pks7 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885108 15608799 Rv1661 NP_216177.1 Probable polyketide synthase pks7 Virulence factor MUTATION: pks7 mutant is attenuated in mice (Rousseau et al., 2003). 12855735
86 pks10 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885112 15608798 Rv1660 NP_216176.1 Possible chalcone synthase pks10 Virulence factor MUTATION: pks10 mutant is attenuated in mice (Sirakova et al., 2003). 12730158
87 Rv1710 Mycobacterium tuberculosis H37Rv 885116 15608848 Rv1710 NP_216226.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
88 coaA Mycobacterium tuberculosis H37Rv 885120 15608232 Rv1092c NP_215608.1 pantothenate kinase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
89 argJ Mycobacterium tuberculosis H37Rv 885125 15608791 Rv1653 NP_216169.1 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
90 prrA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885209 15608043 Rv0903c NP_215418.1 TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA Virulence factor MUTATION: prrA mutant is attenuated in murine macrophages (Ewann et al., 2002). 11953357
91 cysH from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885250 15609529 Rv2392 NP_216908.1 phosphoadenosine phosphosulfate reductase Virulence factor MUTATION: cysH mutants are attenuated in mice (Senaratne et al., 2006). 16553880
92 ompA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885286 15608039 Rv0899 NP_215414.1 OUTER MEMBRANE PROTEIN A OMPA Virulence factor MUTATION: ompA mutant is impaired in its ability to grow in macrophages and in normal mice, although it was as virulent as the wild type in mice that lack T cells (Raynaud et al., 2002). 12366842
93 Rv3651 Mycobacterium tuberculosis H37Rv 885296 15610787 Rv3651 NP_218168.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
94 hemN Mycobacterium tuberculosis H37Rv 885300 15609525 Rv2388c NP_216904.1 coproporphyrinogen III oxidase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
95 Rv2387 Mycobacterium tuberculosis H37Rv 885302 15609524 Rv2387 NP_216903.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
96 Rv1747 Mycobacterium tuberculosis H37Rv 885311 15608885 Rv1747 NP_216263.1 PROBABLE CONSERVED TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER Virulence factor MUTATION: Rv1747 mutant is attenuated in mice (Curry et al., 2005). 16040957
97 Rv3631 Mycobacterium tuberculosis H37Rv 885314 15610767 Rv3631 NP_218148.1 POSSIBLE TRANSFERASE (POSSIBLY GLYCOSYLTRANSFERASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
98 Rv1930c Mycobacterium tuberculosis H37Rv 885344 15609067 Rv1930c NP_216446.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
99 Rv0986 Mycobacterium tuberculosis H37Rv 885364 15608126 Rv0986 NP_215501.1 PROBABLE ADHESION COMPONENT TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER Virulence factor MUTATION: Rv0986 mutant is attenuated in survival within macrophages (Pethe et al., 2004). 15340136
100 Rv3616c Mycobacterium tuberculosis H37Rv 885377 15610752 Rv3616c NP_218133.1 CONSERVED HYPOTHETICAL ALANINE AND GLYCINE RICH PROTEIN Virulence factor MUTATION: Rv3616c mutant is attenuated in mice (Fortune et al., 2005). 16030141
101 pepD from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885382 15608123 Rv0983 NP_215498.1 PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B) Virulence factor MUTATION: pepD mutant has altered virulence in mouse model of infection (White et al., 2010). 20061478
102 lysS Mycobacterium tuberculosis H37Rv 885428 15608778 Rv1640c NP_216156.1 lysyl-tRNA synthetase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
103 Rv1931c Mycobacterium tuberculosis H37Rv 885437 15609068 Rv1931c NP_216447.1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
104 Rv0950c Mycobacterium tuberculosis H37Rv 885438 15608090 Rv0950c NP_215465.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
105 mgtC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885439 15608948 Rv1811 NP_216327.1 POSSIBLE Mg2+ TRANSPORT P-TYPE ATPASE C MGTC Virulence factor MUTATION: mgtC mutant is attenuated in human macrophages and mice (Buchmeier et al., 2000). 10760138
106 Rv1111c Mycobacterium tuberculosis H37Rv 885447 57116830 Rv1111c NP_215627.2 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
107 panC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885459 15610738 Rv3602c NP_218119.1 pantoate--beta-alanine ligase Virulence factor MUTATION: panCD mutant is attenuated in mice (Sambandamurthy et al., 2002). 12219086
108 nirA Mycobacterium tuberculosis H37Rv 885472 15609528 Rv2391 NP_216907.1 PROBABLE FERREDOXIN-DEPENDENT NITRITE REDUCTASE NIRA Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
109 Rv1939 Mycobacterium tuberculosis H37Rv 885488 15609076 Rv1939 NP_216455.1 PROBABLE OXIDOREDUCTASE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
110 Rv3676 Mycobacterium tuberculosis H37Rv 885502 15610812 Rv3676 NP_218193.1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY CRP/FNR-FAMILY) Virulence factor MUTATION: Rv3676 mutant is attenuated in human macrophages and mice (Rickman et al., 2005). 15882420
111 Rv3701c Mycobacterium tuberculosis H37Rv 885521 15610837 Rv3701c NP_218218.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
112 secA2 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885594 15608958 Rv1821 NP_216337.1 preprotein translocase subunit SecA Virulence factor MUTATION: secA2 mutant is attenuated in mice (Braunstein et al., 2003). 12675804
113 panD from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885596 15610737 Rv3601c NP_218118.1 aspartate alpha-decarboxylase Virulence factor MUTATION: panCD mutant is attenuated in mice (Sambandamurthy et al., 2002). 12219086
114 Rv3717 Mycobacterium tuberculosis H37Rv 885602 15610853 Rv3717 NP_218234.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
115 katG from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885638 15609045 Rv1908c NP_216424.1 CATALASE-PEROXIDASE-PEROXYNITRITASE T KATG Virulence factor MUTATION: katG mutant is attenuated in mice and guinea pigs (Li et al., 1998). 9534978
116 ahpC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885717 15609565 Rv2428 NP_216944.1 ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C) Virulence factor MUTATION: ahpC mutant has decreased survival in unstimulated macrophages compared to the wild type (Master et al., 2002). 12368447
117 Rv3615c Mycobacterium tuberculosis H37Rv 885770 15610751 Rv3615c NP_218132.1 hypothetical protein Virulence factor MUTATION: Rv3615c mutant is attenuated in mice and has growth defects in macrophages (MacGurn et al., 2005). 16135231
118 Rv3614c Mycobacterium tuberculosis H37Rv 885777 15610750 Rv3614c NP_218131.1 hypothetical protein Virulence factor MUTATION: Rv3614c mutant is attenuated in mice and has growth defects in macrophages (MacGurn et al., 2005). 16135231
119 Rv3683 Mycobacterium tuberculosis H37Rv 885780 15610819 Rv3683 NP_218200.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
120 Rv3723 Mycobacterium tuberculosis H37Rv 885791 15610859 Rv3723 NP_218240.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
121 recN Mycobacterium tuberculosis H37Rv 885805 15608834 Rv1696 NP_216212.1 PROBABLE DNA REPAIR PROTEIN RECN (RECOMBINATION PROTEIN N) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
122 Rv1524 Mycobacterium tuberculosis H37Rv 885814 15608662 Rv1524 NP_216040.1 Probable glycosyltransferase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
123 Rv1109c Mycobacterium tuberculosis H37Rv 885828 15608249 Rv1109c NP_215625.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
124 mbtB from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885838 15609520 Rv2383c NP_216899.1 PHENYLOXAZOLINE SYNTHASE MBTB (PHENYLOXAZOLINE SYNTHETASE) Virulence factor MUTATION: mbtB mutant is attenuated in macrophage like THP-1 cells (De et al., 2000). 10655517
125 Rv3649 Mycobacterium tuberculosis H37Rv 885841 15610785 Rv3649 NP_218166.1 PROBABLE HELICASE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
126 Rv1128c Mycobacterium tuberculosis H37Rv 885849 15608268 Rv1128c NP_215644.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
127 glpX Mycobacterium tuberculosis H37Rv 885861 15608239 Rv1099c NP_215615.1 fructose 1,6-bisphosphatase II Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
128 Rv2437 Mycobacterium tuberculosis H37Rv 885906 15609574 Rv2437 NP_216953.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
129 hrcA Mycobacterium tuberculosis H37Rv 885924 15609511 Rv2374c NP_216890.1 heat-inducible transcription repressor Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
130 hspR from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885929 15607494 Rv0353 NP_214867.1 PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL REPRESSOR HSPR (MERR FAMILY) Virulence factor MUTATION: hspR is attenuated in mice (Stewart et al., 2001). 11385512
131 Rv1144 Mycobacterium tuberculosis H37Rv 885932 15608284 Rv1144 NP_215660.1 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
132 Rv1974 Mycobacterium tuberculosis H37Rv 885935 15609111 Rv1974 NP_216490.1 PROBABLE CONSERVED MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
133 mce3A from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885944 57116931 Rv1966 YP_177852.1 MCE-FAMILY PROTEIN MCE3A Virulence factor MUTATION: mce3A mutant is attenuated in mice (Gioffré et al., 2005). 15804490
134 plcA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885995 15609488 Rv2351c NP_216867.1 PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA (MTP40 ANTIGEN) Virulence factor MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002). 12100560
135 plcB from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 885999 15609487 Rv2350c NP_216866.1 PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB Virulence factor MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002). 12100560
136 plcC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886000 15609486 Rv2349c NP_216865.1 PROBABLE PHOSPHOLIPASE C 3 PLCC Virulence factor MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002). 12100560
137 Rv1192 Mycobacterium tuberculosis H37Rv 886007 15608332 Rv1192 NP_215708.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
138 furB Mycobacterium tuberculosis H37Rv 886009 15609496 Rv2359 NP_216875.1 PROBABLE FERRIC UPTAKE REGULATION PROTEIN FURB Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
139 cysE Mycobacterium tuberculosis H37Rv 886012 15609472 Rv2335 NP_216851.1 PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
140 Rv0386 Mycobacterium tuberculosis H37Rv 886030 15607527 Rv0386 NP_214900.1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LUXR/UHPA-FAMILY) Virulence factor MUTATION: Rv0386 mutant is attenuated in mice (Paige and Bishai, 2010). 20039878
141 pks16 Mycobacterium tuberculosis H37Rv 886035 15608153 Rv1013 NP_215529.1 acyl-CoA synthetase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
142 Rv1021 Mycobacterium tuberculosis H37Rv 886052 15608161 Rv1021 NP_215537.1 nucleoside triphosphate pyrophosphohydrolase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
143 Rv1184c Mycobacterium tuberculosis H37Rv 886063 15608324 Rv1184c NP_215700.1 POSSIBLE EXPORTED PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
144 fadD21 Mycobacterium tuberculosis H37Rv 886065 15608325 Rv1185c NP_215701.1 acyl-CoA synthetase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
145 lpqT Mycobacterium tuberculosis H37Rv 886066 15608156 Rv1016c NP_215532.1 PROBABLE CONSERVED LIPOPROTEIN LPQT Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
146 mmpL10 Mycobacterium tuberculosis H37Rv 886068 15608323 Rv1183 NP_215699.1 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL10 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
147 kdpD Mycobacterium tuberculosis H37Rv 886084 15608168 Rv1028c NP_215544.1 PROBABLE SENSOR PROTEIN KDPD Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
148 rfbE Mycobacterium tuberculosis H37Rv 886113 15610917 Rv3781 NP_218298.1 PROBABLE O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER RFBE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
149 embA Mycobacterium tuberculosis H37Rv 886123 15610930 Rv3794 NP_218311.1 INTEGRAL MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBA (ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
150 fbpA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886132 15610940 Rv3804c NP_218321.1 SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) (ANTIGEN 85 COMPLEX A) Virulence factor MUTATION: fbpA mutant is attenuated in mice (Copenhaver et al., 2004). 15557632
151 Rv3805c Mycobacterium tuberculosis H37Rv 886138 15610941 Rv3805c NP_218322.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
152 pirG Mycobacterium tuberculosis H37Rv 886139 15610946 Rv3810 NP_218327.1 EXPORTED REPETITIVE PROTEIN PRECURSOR PIRG (CELL SURFACE PROTEIN) (EXP53) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
153 mmpL8 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886145 15610959 Rv3823c NP_218340.1 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN MMPL8 Virulence factor MUTATION: mmpL8 mutant is attenuated in mice (Converse et al., 2003). 12724526
154 Rv3869 Mycobacterium tuberculosis H37Rv 886166 15611005 Rv3869 NP_218386.1 POSSIBLE CONSERVED MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
155 Rv3865 Mycobacterium tuberculosis H37Rv 886172 15611001 Rv3865 NP_218382.1 hypothetical protein Virulence factor MUTATION: Rv3865 mutant is attenuated in mice (Brodin et al., 2006). 16368961
156 sodA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886174 15610982 Rv3846 NP_218363.1 SUPEROXIDE DISMUTASE [FE] SODA Virulence factor MUTATION: sodA mutant is attenuated in mice (Edwards et al., 2001). 11751190
157 Rv3864 Mycobacterium tuberculosis H37Rv 886185 15611000 Rv3864 NP_218381.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
158 ethR Mycobacterium tuberculosis H37Rv 886189 15610991 Rv3855 NP_218372.1 TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
159 PE35 Mycobacterium tuberculosis H37Rv 886191 57117163 Rv3872 YP_178021.1 PE FAMILY-RELATED PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
160 esxB from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886194 15611010 Rv3874 NP_218391.1 10 KDA CULTURE FILTRATE ANTIGEN ESXB (LHP) (CFP10) Virulence factor MUTATION: esxB (CFP-10) mutant is attenuated in mice (Fortune et al., 2005). 16030141
161 Rv3868 Mycobacterium tuberculosis H37Rv 886199 15611004 Rv3868 NP_218385.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
162 Rv3866 Mycobacterium tuberculosis H37Rv 886200 15611002 Rv3866 NP_218383.1 hypothetical protein Virulence factor MUTATION: Rv3866 mutant is attenuated in mice (Brodin et al., 2006). 16368961
163 PPE68 Mycobacterium tuberculosis H37Rv 886201 57117164 Rv3873 YP_178022.1 PPE FAMILY PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
164 Rv3871 Mycobacterium tuberculosis H37Rv 886202 15611007 Rv3871 NP_218388.1 hypothetical protein Virulence factor MUTATION: Rv3871 mutant is attenuated in mice (Stanley et al., 2003). 14557536
165 Rv3870 Mycobacterium tuberculosis H37Rv 886204 15611006 Rv3870 NP_218387.1 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: Rv3870 mutant is attenuated in mice (Stanley et al., 2003). 14557536
166 Rv3876 Mycobacterium tuberculosis H37Rv 886206 15611012 Rv3876 NP_218393.1 CONSERVED HYPOTHETICAL PROLINE AND ALANINE RICH PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
167 Rv3877 Mycobacterium tuberculosis H37Rv 886207 15611013 Rv3877 NP_218394.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: Rv3877 (snm4) mutant is attenuated in mice (Stanley et al., 2003). 14557536
168 Rv3882c Mycobacterium tuberculosis H37Rv 886208 15611018 Rv3882c NP_218399.1 POSSIBLE CONSERVED MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
169 esxA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886209 57117165 Rv3875 YP_178023.1 6 KDA EARLY SECRETORY ANTIGENIC TARGET ESXA (ESAT-6) Virulence factor MUTATION: esxA (ESAT-6) mutant is attenuated in mice (Fortune et al., 2005). 16030141
170 Rv3887c Mycobacterium tuberculosis H37Rv 886211 15611023 Rv3887c NP_218404.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: Rv3887c mutant is attenuated in mice (MacGurn and Cox, 2007). 17353284
171 Rv3881c Mycobacterium tuberculosis H37Rv 886214 15611017 Rv3881c NP_218398.1 CONSERVED HYPOTHETICAL ALANINE AND GLYCINE RICH PROTEIN Virulence factor MUTATION: Rv3881c (espB) mutant is attenuated in macrophages (McLaughlin et al., 2007). 17676952
172 mycP1 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886217 15611019 Rv3883c NP_218400.1 MEMBRANE-ANCHORED MYCOSIN MYCP1 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-1) Virulence factor MUTATION: mycP1 mutant is attenuated in chronic infection of mice (Ohol et al., 2010). 20227664
173 Rv3910 Mycobacterium tuberculosis H37Rv 886247 15611046 Rv3910 NP_218427.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
174 hbhA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886272 15607616 Rv0475 NP_214989.1 IRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN) Virulence factor MUTATION: hbhA mutant is attenuated in attachment and invasion of pneumocytes (Pethe et al., 2001). 11449276
175 pcaA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886284 57116736 Rv0470c YP_177730.1 MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) Virulence factor MUTATION: pcaA mutant is attenuated in mice (Glickman et al., 2000). 10882107
176 icl from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886291 57116734 Rv0467 YP_177728.1 isocitrate lyase Virulence factor MUTATION: icl mutant is attenuated in activated macrophages (McKinney et al., 2000). 10963599
177 Rv1590 Mycobacterium tuberculosis H37Rv 886292 15608728 Rv1590 NP_216106.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
178 proV Mycobacterium tuberculosis H37Rv 886293 15610894 Rv3758c NP_218275.1 POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
179 bioB Mycobacterium tuberculosis H37Rv 886301 15608727 Rv1589 NP_216105.1 biotin synthase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
180 bioA Mycobacterium tuberculosis H37Rv 886343 15608706 Rv1568 NP_216084.1 adenosylmethionine--8-amino-7-oxononanoate transaminase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
181 bioF1 Mycobacterium tuberculosis H37Rv 886345 57116887 Rv1569 YP_177822.1 8-amino-7-oxononanoate synthase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
182 sodC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886358 15607573 Rv0432 NP_214946.1 PROBABLE PERIPLASMIC SUPEROXIDE DISMUTASE [CU-ZN] SODC Virulence factor MUTATION: sodC mutant is more susceptible to killing by activated murine macrophages than the wild type (Piddington et al., 2001). 11447176
183 Rv1560 Mycobacterium tuberculosis H37Rv 886359 15608698 Rv1560 NP_216076.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
184 xthA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886370 15607568 Rv0427c NP_214941.1 PROBABLE EXODEOXYRIBONUCLEASE III PROTEIN XTHA (EXONUCLEASE III) (EXO III) (AP ENDONUCLEASE VI) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
185 thiE Mycobacterium tuberculosis H37Rv 886391 15607555 Rv0414c NP_214928.1 thiamine-phosphate pyrophosphorylase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
186 pknG from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886397 15607551 Rv0410c NP_214924.1 SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G) Virulence factor MUTATION: pknG mutant is attenuated in mice (Cowley et al., 2004). 15186418
187 lspA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886408 15608677 Rv1539 NP_216055.1 lipoprotein signal peptidase Virulence factor MUTATION: lspA mutant is attenuated in mice (Rampini et al., 2008). 18832305
188 pks5 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886442 15608665 Rv1527c NP_216043.1 Probable polyketide synthase pks5 Virulence factor MUTATION: pks5 mutant is attenuated in mice (Rousseau et al., 2003). 12855735
189 Rv1514c Mycobacterium tuberculosis H37Rv 886457 15608652 Rv1514c NP_216030.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
190 Rv0326 Mycobacterium tuberculosis H37Rv 886544 15607467 Rv0326 NP_214840.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
191 Rv1465 Mycobacterium tuberculosis H37Rv 886569 15608603 Rv1465 NP_215981.1 POSSIBLE NITROGEN FIXATION RELATED PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
192 Rv1460 Mycobacterium tuberculosis H37Rv 886573 57116868 Rv1460 NP_215976.2 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
193 ctpD Mycobacterium tuberculosis H37Rv 886578 15608607 Rv1469 NP_215985.1 PROBABLE CATION TRANSPORTER P-TYPE ATPASE D CTPD Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
194 Rv1422 Mycobacterium tuberculosis H37Rv 886670 15608560 Rv1422 NP_215938.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
195 Rv0249c Mycobacterium tuberculosis H37Rv 886671 15607390 Rv0249c NP_214763.1 PROBABLE SUCCINATE DEHYDROGENASE [MEMBRANE ANCHOR SUBUNIT] (SUCCINIC DEHYDROGENASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
196 lprG Mycobacterium tuberculosis H37Rv 886700 15608549 Rv1411c NP_215927.1 PROBABLE CONSERVED LIPOPROTEIN LPRG Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
197 Rv1410c Mycobacterium tuberculosis H37Rv 886709 15608548 Rv1410c NP_215926.1 AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
198 Rv1405c Mycobacterium tuberculosis H37Rv 886714 15608543 Rv1405c NP_215921.1 PUTATIVE METHYLTRANSFERASE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
199 Rv0218 Mycobacterium tuberculosis H37Rv 886727 15607359 Rv0218 NP_214732.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
200 Rv0216 Mycobacterium tuberculosis H37Rv 886729 15607357 Rv0216 NP_214730.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
201 Rv0204c Mycobacterium tuberculosis H37Rv 886747 15607345 Rv0204c NP_214718.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
202 mmpL11 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886750 15607343 Rv0202c NP_214716.1 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11 Virulence factor MUTATION: mmpL11 mutant is attenuated in mice (Domenech et al., 2005). 15908378
203 Rv0199 Mycobacterium tuberculosis H37Rv 886753 15607340 Rv0199 NP_214713.1 PROBABLE CONSERVED MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
204 Rv0176 Mycobacterium tuberculosis H37Rv 886799 15607317 Rv0176 NP_214690.1 PROBABLE CONSERVED MCE ASSOCIATED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
205 Rv1371 Mycobacterium tuberculosis H37Rv 886800 15608511 Rv1371 NP_215887.1 PROBABLE CONSERVED MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
206 Rv0175 Mycobacterium tuberculosis H37Rv 886801 15607316 Rv0175 NP_214689.1 PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
207 lprK Mycobacterium tuberculosis H37Rv 886804 15607314 Rv0173 NP_214687.1 POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
208 mce1C Mycobacterium tuberculosis H37Rv 886808 15607312 Rv0171 NP_214685.1 MCE-FAMILY PROTEIN MCE1C Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
209 mce1B Mycobacterium tuberculosis H37Rv 886810 15607311 Rv0170 NP_214684.1 MCE-FAMILY PROTEIN MCE1B Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
210 yrbE1B from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886812 15607309 Rv0168 NP_214682.1 CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE1B Virulence factor MUTATION: yrbE1B mutant is attenuated in mice (Gioffré et al., 2005). 15804490
211 fadD5 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886822 15607307 Rv0166 NP_214680.1 acyl-CoA synthetase Virulence factor MUTATION: fadD5 mutant is attenuated in mice (Dunphy et al., 2010). 20214478
212 mce1A Mycobacterium tuberculosis H37Rv 886823 57116701 Rv0169 YP_177701.1 MCE-FAMILY PROTEIN MCE1A Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
213 fadD33 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 886855 15608485 Rv1345 NP_215861.1 acyl-CoA synthetase Virulence factor MUTATION: fadD33 mutant is attenuated in mice (Rindi et al., 2002). 12480891
214 murI Mycobacterium tuberculosis H37Rv 886866 15608478 Rv1338 NP_215854.1 glutamate racemase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
215 Rv1333 Mycobacterium tuberculosis H37Rv 886882 15608473 Rv1333 NP_215849.1 PROBABLE HYDROLASE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
216 Rv1332 Mycobacterium tuberculosis H37Rv 886901 15608472 Rv1332 NP_215848.1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
217 fadA4 Mycobacterium tuberculosis H37Rv 886904 15608463 Rv1323 NP_215839.1 acetyl-CoA acetyltransferase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
218 Rv0100 Mycobacterium tuberculosis H37Rv 886931 15607242 Rv0100 NP_214614.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
219 fadD10 Mycobacterium tuberculosis H37Rv 886933 15607241 Rv0099 NP_214613.1 acyl-CoA synthetase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
220 Rv0098 Mycobacterium tuberculosis H37Rv 886935 15607240 Rv0098 NP_214612.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
221 atpB Mycobacterium tuberculosis H37Rv 886941 15608444 Rv1304 NP_215820.1 F0F1 ATP synthase subunit A Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
222 nrp Mycobacterium tuberculosis H37Rv 886951 15607243 Rv0101 NP_214615.1 PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) Virulence factor MUTATION attenuated in mice (Sassetti and Rubin, 2003). 14569030
223 Rv1284 Mycobacterium tuberculosis H37Rv 886987 15608424 Rv1284 NP_215800.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
224 Rv1272c Mycobacterium tuberculosis H37Rv 887021 15608412 Rv1272c NP_215788.1 PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
225 ino1 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887028 15607188 Rv0046c NP_214560.1 MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) (Glucocycloaldolase) Virulence factor MUTATION: ino1 mutant is attenuated in resting macrophages and guinea pigs (Movahedzadeh et al., 2004). 14763976
226 lpqZ Mycobacterium tuberculosis H37Rv 887093 15608384 Rv1244 NP_215760.1 PROBABLE LIPOPROTEIN LPQZ Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
227 sugC Mycobacterium tuberculosis H37Rv 887104 15608378 Rv1238 NP_215754.1 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003) 14569030
228 sugB Mycobacterium tuberculosis H37Rv 887121 15608377 Rv1237 NP_215753.1 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
229 sugA Mycobacterium tuberculosis H37Rv 887124 15608376 Rv1236 NP_215752.1 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
230 tatB Mycobacterium tuberculosis H37Rv 887143 15608364 Rv1224 NP_215740.1 sec-independent translocase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
231 lpqY Mycobacterium tuberculosis H37Rv 887145 15608375 Rv1235 NP_215751.1 PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
232 accD1 Mycobacterium tuberculosis H37Rv 887168 15609639 Rv2502c NP_217018.1 PROBABLE ACETYL-/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD1 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
233 Rv0485 Mycobacterium tuberculosis H37Rv 887170 15607626 Rv0485 NP_214999.1 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Virulence factor MUTATION: Rv0485 mutant is attenuated in mice (Goldstone et al., 2009). 19651861
234 Rv2885c Mycobacterium tuberculosis H37Rv 887173 15610022 Rv2885c NP_217401.1 PROBABLE TRANSPOSASE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
235 senX3 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887185 15607631 Rv0490 NP_215004.1 PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 Virulence factor MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003). 12777483
236 regX3 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887195 15607632 Rv0491 NP_215005.1 TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) Virulence factor MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003). 12777483
237 Rv3574 Mycobacterium tuberculosis H37Rv 887204 15610710 Rv3574 NP_218091.1 TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
238 ftsY Mycobacterium tuberculosis H37Rv 887205 15610058 Rv2921c NP_217437.1 PROBABLE CELL DIVISION PROTEIN FTSY (SRP RECEPTOR) (SIGNAL RECOGNITION PARTICLE RECEPTOR) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
239 gcvT Mycobacterium tuberculosis H37Rv 887233 15609348 Rv2211c NP_216727.1 glycine cleavage system aminomethyltransferase T Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
240 Rv3551 Mycobacterium tuberculosis H37Rv 887235 15610687 Rv3551 NP_218068.1 POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
241 aceE Mycobacterium tuberculosis H37Rv 887246 15609378 Rv2241 NP_216757.1 pyruvate dehydrogenase subunit E1 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
242 Rv3519 Mycobacterium tuberculosis H37Rv 887247 15610655 Rv3519 NP_218036.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
243 Rv2472 Mycobacterium tuberculosis H37Rv 887255 15609609 Rv2472 NP_216988.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
244 proC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887256 15607641 Rv0500 NP_215014.1 pyrroline-5-carboxylate reductase Virulence factor MUTATION: proC mutant is attenuated in mice (Smith et al., 2001). 11160012
245 fadA6 Mycobacterium tuberculosis H37Rv 887285 15610692 Rv3556c NP_218073.1 acetyl-CoA acetyltransferase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
246 ilvB1 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887286 57117044 Rv3003c YP_177917.1 acetolactate synthase 1 catalytic subunit Virulence factor MUTATION: ilvB1 mutant is attenuated in mice (Awasthy et al., 2009). 19542000
247 pks15 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887291 15610084 Rv2947c NP_217463.1 PROBABLE POLYKETIDE SYNTHASE PKS15 Virulence factor MUTATION: pks15 mutant is attenuated in mice (Sirakova et al., 2003). 12730158
248 ppgK Mycobacterium tuberculosis H37Rv 887313 15609839 Rv2702 NP_217218.1 POLYPHOSPHATE GLUCOKINASE PPGK (POLYPHOSPHATE-GLUCOSE PHOSPHOTRANSFERASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
249 ung Mycobacterium tuberculosis H37Rv 887410 15610113 Rv2976c NP_217492.1 uracil-DNA glycosylase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
250 fadD28 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887454 15610078 Rv2941 NP_217457.1 acyl-CoA synthetase Virulence factor MUTATION: fadD28 mutant is attenuated in mice (Cox et al., 1999). 10573420
251 ceoC Mycobacterium tuberculosis H37Rv 887493 57117016 Rv2692 YP_177901.1 TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOC Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
252 mmpL7 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887548 15610079 Rv2942 NP_217458.1 CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL7 Virulence factor MUTATION: mmpL7 mutant is attenuated in mice (Cox et al., 1999). 10573420
253 Rv1204c Mycobacterium tuberculosis H37Rv 887552 15608344 Rv1204c NP_215720.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
254 hspX from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887579 15609168 Rv2031c NP_216547.1 HEAT SHOCK PROTEIN HSPX (ALPHA-CRSTALLIN HOMOLOG) (14 kDa ANTIGEN) (HSP16.3) Virulence factor MUTATION: hspX mutant is attenuated in murine macrophages and THP-1 cells (Yuan et al., 1998). 9689123
255 sigD from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887594 15610550 Rv3414c NP_217931.1 RNA polymerase sigma factor SigD Virulence factor MUTATION: sigD mutant is attenuated in human macrophages and mice (Calamita et al., 2005). 15659067
256 gcp Mycobacterium tuberculosis H37Rv 887595 15610555 Rv3419c NP_217936.1 O-sialoglycoprotein endopeptidase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
257 whiB3 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887598 15610552 Rv3416 NP_217933.1 TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB3 Virulence factor MUTATION: whiB3 mutant is attenuated in mice (Steyn et al., 2002). 11880648
258 fadD26 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887603 57117038 Rv2930 NP_217446.2 acyl-CoA synthetase Virulence factor MUTATION: fadD26 mutant is attenuated in mice (Infante et al., 2005). 15958066
259 fadE22 Mycobacterium tuberculosis H37Rv 887617 15610198 Rv3061c NP_217577.1 PROBABLE ACYL-CoA DEHYDROGENASE FADE22 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
260 Rv0566c Mycobacterium tuberculosis H37Rv 887633 15607706 Rv0566c NP_215080.1 nucleotide-binding protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
261 trpD from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887681 15609329 Rv2192c NP_216708.1 anthranilate phosphoribosyltransferase Virulence factor MUTATION: trpD mutant is attenuated in mice (Smith et al., 2001). 11160012
262 fabG from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887697 15610638 Rv3502c NP_218019.1 3-ketoacyl-(acyl-carrier-protein) reductase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
263 plsC Mycobacterium tuberculosis H37Rv 887744 15609620 Rv2483c NP_216999.1 POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONNAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSP) (PSPASE) + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPH Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
264 mce2A from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887745 57116756 Rv0589 YP_177740.1 MCE-FAMILY PROTEIN MCE2A Virulence factor MUTATION: mce2A mutant is attenuated in mice (Gioffré et al., 2005). 15804490
265 Rv2707 Mycobacterium tuberculosis H37Rv 887750 15609844 Rv2707 NP_217223.1 PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
266 cyp125 Mycobacterium tuberculosis H37Rv 887782 15610681 Rv3545c NP_218062.1 PROBABLE CYTOCHROME P450 125 CYP125 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
267 serB2 Mycobacterium tuberculosis H37Rv 887815 15610179 Rv3042c NP_217558.1 phosphoserine phosphatase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
268 fadE32 Mycobacterium tuberculosis H37Rv 887818 15610699 Rv3563 NP_218080.1 PROBABLE ACYL-CoA DEHYDROGENASE FADE32 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
269 Rv3588c Mycobacterium tuberculosis H37Rv 887836 15610724 Rv3588c NP_218105.1 CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
270 fadE30 Mycobacterium tuberculosis H37Rv 887838 15610696 Rv3560c NP_218077.1 PROBABLE ACYL-CoA DEHYDROGENASE FADE30 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
271 Rv2224c Mycobacterium tuberculosis H37Rv 887857 15609361 Rv2224c NP_216740.1 Probable exported protease Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
272 relA from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 887888 15609720 Rv2583c NP_217099.1 PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'-PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE) Virulence factor MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism (Primm et al., 2000). 10940033
273 Rv2040c Mycobacterium tuberculosis H37Rv 887893 15609177 Rv2040c NP_216556.1 Probable sugar-transport integral membrane protein ABC transporter Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
274 Rv2693c Mycobacterium tuberculosis H37Rv 887917 15609830 Rv2693c NP_217209.1 PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND LEUCINE RICH PROTEIN Virulence factor MUTATION: Rv2693c mutant is attenuated in mice (MacGurn and Cox, 2007). 17353284
275 Rv3400 Mycobacterium tuberculosis H37Rv 887918 15610536 Rv3400 NP_217917.1 PROBABLE HYDROLASE Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
276 lppX Mycobacterium tuberculosis H37Rv 887956 15610082 Rv2945c NP_217461.1 PROBABLE CONSERVED LIPOPROTEIN LPPX Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
277 drrB Mycobacterium tuberculosis H37Rv 887968 15610074 Rv2937 NP_217453.1 PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRB Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
278 Rv1211 Mycobacterium tuberculosis H37Rv 887990 15608351 Rv1211 NP_215727.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
279 Rv2038c Mycobacterium tuberculosis H37Rv 887998 15609175 Rv2038c NP_216554.1 Probable sugar-transport ATP-binding protein ABC transporter Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
280 Rv3472 Mycobacterium tuberculosis H37Rv 888006 15610608 Rv3472 NP_217989.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
281 Rv2912c Mycobacterium tuberculosis H37Rv 888017 15610049 Rv2912c NP_217428.1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
282 Rv3335c Mycobacterium tuberculosis H37Rv 888029 15610471 Rv3335c NP_217852.1 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
283 Rv0636 Mycobacterium tuberculosis H37Rv 888031 15607776 Rv0636 NP_215150.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
284 Rv3371 Mycobacterium tuberculosis H37Rv 888053 15610507 Rv3371 NP_217888.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
285 mmaA3 Mycobacterium tuberculosis H37Rv 888058 15607783 Rv0643c NP_215157.1 METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
286 amiD Mycobacterium tuberculosis H37Rv 888064 15610511 Rv3375 NP_217892.1 PROBABLE AMIDASE AMID (ACYLAMIDASE) (ACYLASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
287 Rv3377c Mycobacterium tuberculosis H37Rv 888073 15610513 Rv3377c NP_217894.1 POSSIBLE CYCLASE Virulence factor MUTATION: Rv3377c mutant is attenuated in survival inside of macrophages (Pethe et al., 2004). 15340136
288 Rv3378c Mycobacterium tuberculosis H37Rv 888075 15610514 Rv3378c NP_217895.1 hypothetical protein Virulence factor MUTATION: Rv3378c mutant is attenuated in survival within macrophages (Pethe et al., 2004). 15340136
289 mkl Mycobacterium tuberculosis H37Rv 888081 15607795 Rv0655 NP_215169.1 POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
290 fadE28 Mycobacterium tuberculosis H37Rv 888091 15610680 Rv3544c NP_218061.1 PROBABLE ACYL-CoA DEHYDROGENASE FADE28 Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
291 sigH from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888094 15610359 Rv3223c NP_217739.1 RNA polymerase sigma factor RpoE Virulence factor MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice (Kaushal et al., 2002). 12060776
292 Rv2206 Mycobacterium tuberculosis H37Rv 888107 57116956 Rv2206 NP_216722.2 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: Rv2206 mutant is attenuated in mice (MacGurn and Cox, 2007). 17353284
293 pks1 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888122 15610083 Rv2946c NP_217462.1 PROBABLE POLYKETIDE SYNTHASE PKS1 Virulence factor MUTATION: pks1 mutant is attenuated in mice (Sirakova et al., 2003). 12730158
294 drrA Mycobacterium tuberculosis H37Rv 888168 15610073 Rv2936 NP_217452.1 PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
295 end Mycobacterium tuberculosis H37Rv 888190 15607810 Rv0670 NP_215184.1 endonuclease IV Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
296 leuD from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888225 15610124 Rv2987c NP_217503.1 isopropylmalate isomerase small subunit Virulence factor MUTATION: leuD mutant is attenuated in mice (Hondalus et al., 2000). 10768986
297 Rv2553c Mycobacterium tuberculosis H37Rv 888228 15609690 Rv2553c NP_217069.1 PROBABLE CONSERVED MEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
298 ltp3 Mycobacterium tuberculosis H37Rv 888247 15610659 Rv3523 NP_218040.1 acetyl-CoA acetyltransferase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
299 fabG from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888279 15607827 Rv0687 NP_215201.1 3-ketoacyl-(acyl-carrier-protein) reductase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
300 Rv3527 Mycobacterium tuberculosis H37Rv 888295 15610663 Rv3527 NP_218044.1 hypothetical protein Virulence factor MUTATION: Rv3527 mutant is attenuated for intramacrophage survival (Pethe et al., 2004). 15340136
301 Rv2734 Mycobacterium tuberculosis H37Rv 888303 15609871 Rv2734 NP_217250.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
302 yrbE4A Mycobacterium tuberculosis H37Rv 888320 15610637 Rv3501c NP_218018.1 CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE4A Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
303 cobL Mycobacterium tuberculosis H37Rv 888321 15609209 Rv2072c NP_216588.1 Probable precorrin-6y methyltransferase CobL Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
304 cobC Mycobacterium tuberculosis H37Rv 888337 15609368 Rv2231c NP_216747.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
305 mce4A from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888344 57117113 Rv3499c YP_177977.1 MCE-FAMILY PROTEIN MCE4A Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
306 pks12 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888350 15609185 Rv2048c NP_216564.1 Probable polyketide synthase pks12 Virulence factor MUTATION: pks12 mutant is attenuated in mice (Sirakova et al., 2003). 12819062
307 mce4C Mycobacterium tuberculosis H37Rv 888354 15610633 Rv3497c NP_218014.1 MCE-FAMILY PROTEIN MCE4C Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
308 Rv2275 Mycobacterium tuberculosis H37Rv 888355 15609412 Rv2275 NP_216791.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
309 lprN Mycobacterium tuberculosis H37Rv 888364 15610631 Rv3495c NP_218012.1 POSSIBLE MCE-FAMILY LIPOPROTEIN LPRN (MCE-FAMILY LIPOPROTEIN MCE4E) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
310 Rv3534c Mycobacterium tuberculosis H37Rv 888387 15610670 Rv3534c NP_218051.1 4-hydroxy-2-ketovalerate aldolase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
311 Rv3489 Mycobacterium tuberculosis H37Rv 888410 15610625 Rv3489 NP_218006.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
312 ddl Mycobacterium tuberculosis H37Rv 888415 15610118 Rv2981c NP_217497.1 D-alanyl-alanine synthetase A Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
313 lipF from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888430 15610623 Rv3487c NP_218004.1 PROBABLE ESTERASE/LIPASE LIPF Virulence factor MUTATION: lipF mutant is attenuated in mice lungs (Camacho et al., 1999). 10564470
314 cpsA Mycobacterium tuberculosis H37Rv 888445 15610620 Rv3484 NP_218001.1 POSSIBLE CONSERVED PROTEIN CPSA Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
315 ltp2 Mycobacterium tuberculosis H37Rv 888450 15610676 Rv3540c NP_218057.1 lipid-transfer protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
316 Rv3541c Mycobacterium tuberculosis H37Rv 888475 15610677 Rv3541c NP_218058.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
317 Rv2696c Mycobacterium tuberculosis H37Rv 888482 15609833 Rv2696c NP_217212.1 CONSERVED HYPOTHETICAL ALANINE AND GLYCINE AND VALINE RICH PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
318 Rv3542c Mycobacterium tuberculosis H37Rv 888486 15610678 Rv3542c NP_218059.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
319 drrC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888491 15610075 Rv2938 NP_217454.1 PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC Virulence factor MUTATION: drrC mutant is attenuated in mice (Camacho et al., 1999). 10564470
320 Rv2277c Mycobacterium tuberculosis H37Rv 888498 15609414 Rv2277c NP_216793.1 Possible glycerolphosphodiesterase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
321 proS Mycobacterium tuberculosis H37Rv 888539 15609982 Rv2845c NP_217361.1 prolyl-tRNA synthetase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
322 Rv2857c Mycobacterium tuberculosis H37Rv 888560 15609994 Rv2857c NP_217373.1 short chain dehydrogenase Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
323 Rv2813 Mycobacterium tuberculosis H37Rv 888570 15609950 Rv2813 NP_217329.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
324 sigL from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888609 15607875 Rv0735 NP_215249.1 RNA polymerase sigma factor SigL Virulence factor MUTATION: sigL mutant is attenuated in mice (Hahn et al., 2005). 16199577
325 Rv2998 Mycobacterium tuberculosis H37Rv 888646 15610135 Rv2998 NP_217514.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
326 Rv3087 Mycobacterium tuberculosis H37Rv 888653 15610224 Rv3087 NP_217603.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
327 Rv3258c Mycobacterium tuberculosis H37Rv 888694 15610394 Rv3258c NP_217775.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
328 ctpC Mycobacterium tuberculosis H37Rv 888705 15610406 Rv3270 NP_217787.1 PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C CTPC Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
329 sigC from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888723 15609206 Rv2069 NP_216585.1 RNA polymerase sigma factor SigC Virulence factor MUTATION: sigC mutant is attenuated in mice (Sun et al., 2004). 15049808
330 sigF from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888727 15610422 Rv3286c NP_217803.1 RNA polymerase sigma factor SigF Virulence factor MUTATION: sigF mutant is attenuated in mice (Geiman et al., 2004). 14977982
331 Rv3277 Mycobacterium tuberculosis H37Rv 888729 15610413 Rv3277 NP_217794.1 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
332 mtrA Mycobacterium tuberculosis H37Rv 888743 15610382 Rv3246c NP_217763.1 TWO COMPONENT SENSORY TRANSDUCTION TRANSCRIPTIONAL REGULATORY PROTEIN MTRA Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
333 sigE from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888751 15608361 Rv1221 NP_215737.1 RNA polymerase sigma factor SigE Virulence factor MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type (Manganelli et al., 2001). 11489128
334 phoP from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888772 15607897 Rv0757 NP_215271.1 POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP Virulence factor MUTATION: phoP mutant is attenuated in mice (Pérez et al., 2001). 11454210
335 Rv3168 Mycobacterium tuberculosis H37Rv 888778 15610304 Rv3168 NP_217684.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
336 Rv3114 Mycobacterium tuberculosis H37Rv 888779 15610251 Rv3114 NP_217630.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
337 Rv3178 Mycobacterium tuberculosis H37Rv 888786 15610314 Rv3178 NP_217694.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
338 Rv3103c Mycobacterium tuberculosis H37Rv 888798 15610240 Rv3103c NP_217619.1 HYPOTHETICAL PROLINE-RICH PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
339 Rv2004c Mycobacterium tuberculosis H37Rv 888817 15609141 Rv2004c NP_216520.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
340 Rv3229c Mycobacterium tuberculosis H37Rv 888821 57117078 Rv3229c YP_177948.1 POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
341 devR from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888842 15610269 Rv3133c NP_217649.1 TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY) Virulence factor MUTATION: devR mutant is attenuated in guinea pigs (Malhotra et al., 2004). 14987770
342 Rv3236c Mycobacterium tuberculosis H37Rv 888861 57117079 Rv3236c YP_177949.1 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
343 Rv3050c Mycobacterium tuberculosis H37Rv 888866 15610187 Rv3050c NP_217566.1 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY) Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
344 moeB1 from Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv 888871 57117072 Rv3206c YP_177942.1 molybdopterin biosynthesis-like protein MoeZ Virulence factor MUTATION: moeB1 mutant is attenuated in mice (MacGurn and Cox, 2007). 17353284
345 Rv3210c Mycobacterium tuberculosis H37Rv 888876 15610346 Rv3210c NP_217726.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
346 Rv2808 Mycobacterium tuberculosis H37Rv 888944 15609945 Rv2808 NP_217324.1 hypothetical protein Virulence factor MUTATION: attenuated in mice (Sassetti and Rubin, 2003). 14569030
1648 lspA from Mycobacterium tuberculosis F11 Mycobacterium tuberculosis F11 5222252 148822762 TBFG_11572 YP_001287517.1 lipoprotein signal peptidase Virulence factor MUTATION: lspA mutant is attenuated in mice (Rampini et al., 2008). 18832305
1649 trpD from Mycobacterium tuberculosis F11 Mycobacterium tuberculosis F11 5222896 148823399 TBFG_12220 YP_001288153.1 anthranilate phosphoribosyltransferase Virulence factor MUTATION: trpD mutant is attenuated in mice (Smith et al., 2001). 11160012
1650 leuD from Mycobacterium tuberculosis F11 Mycobacterium tuberculosis F11 5223688 148824177 TBFG_13002 YP_001288931.1 isopropylmalate isomerase small subunit Virulence factor MUTATION: leuD mutant is attenuated in mice (Hondalus et al., 2000). 10768986
1651 panC from Mycobacterium tuberculosis F11 Mycobacterium tuberculosis F11 5224323 148824807 TBFG_13634 YP_001289561.1 pantoate--beta-alanine ligase Virulence factor MUTATION: pan CD mutant is attenuated in mice (Sambandamurthy et al., 2002). 12219086
1845 mgtC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211668 148661617 MRA_1823 YP_001283140.1 Mg2+ transport P-type ATPase C Virulence factor MUTATION: mgtC mutant is attenuated in human macrophages and mice (Buchmeier et al., 2000). 10760138
1846 hspR from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211729 148660119 MRA_0362 YP_001281642.1 heat shock protein transcriptional repressor HspR Virulence factor MUTATION: hspR mutant is attenuated in mice (Stewart et al., 2001). 11385512
1847 sigD from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211733 148663278 MRA_3454 YP_001284801.1 RNA polymerase sigma factor SigD Virulence factor MUTATION: sigD mutant is attenuated in human macrophages and mice (Calamita et al., 2005). 15659067
1848 whiB3 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211735 148663280 MRA_3456 YP_001284803.1 transcriptional regulatory protein whib-like WhiB3 Virulence factor MUTATION: whiB3 mutant is attenuated in mice (Steyn et al., 2002). 11880648
1849 mce2A from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211750 148660358 MRA_0596 YP_001281881.1 MCE-family protein Mce2A Virulence factor MUTATION: mce2A mutant is attenuated in mice (Gioffré et al., 2005). 15804490
1850 hbhA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211814 148660242 MRA_0482 YP_001281765.1 iron-regulated heparin binding hemagglutinin Hbha Virulence factor MUTATION: hbhA mutant is attenuated in attachment and invasion of pneumocytes (Pethe et al., 2001). 11449276
1851 pks12 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211927 148661862 MRA_2063 YP_001283385.1 polyketide synthase Pks12 Virulence factor MUTATION: pks12 mutant is attenuated in mice (Sirakova et al., 2003). 12819062
1852 mce3A from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5211946 148661775 MRA_1977 YP_001283298.1 MCE-family protein Mce3A Virulence factor MUTATION: mce3A mutant is attenuated in mice (Gioffré et al., 2005). 15804490
1853 fadD5 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212238 148659930 MRA_0174 YP_001281453.1 acyl-CoA synthetase Virulence factor MUTATION: fadD5 mutant is attenuated in mice (Dunphy et al., 2010). 20214478
1854 sigL from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212242 148660510 MRA_0743 YP_001282033.1 RNA polymerase sigma factor SigL Virulence factor MUTATION: sigL mutant is attenuated in mice (Hahn et al., 2005). 16199577
1855 mmpL11 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212263 148659966 MRA_0210 YP_001281489.1 membrane protein MmpL11 Virulence factor MUTATION: mmpL11 mutant is attenuated in mice (Domenech et al., 2005). 15908378
1856 senX3 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212269 148660257 MRA_0497 YP_001281780.1 putative two component sensor histidine kinase SenX3 Virulence factor MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003). 12777483
1857 regX3 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212270 148660258 MRA_0498 YP_001281781.1 two component sensory transduction protein RegX3 Virulence factor MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003). 12777483
1858 plcC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212285 148662177 MRA_2369 YP_001283700.1 phospholipase C 3 PlcC Virulence factor MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002). 12100560
1859 plcB from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212286 148662178 MRA_2370 YP_001283701.1 membrane-associated phospholipase C 2 Virulence factor MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002). 12100560
1860 plcA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212287 148662179 MRA_2371 YP_001283702.1 membrane-associated phospholipase C 1 Virulence factor MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002). 12100560
1861 devR from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212298 148662987 MRA_3165 YP_001284510.1 two component transcriptional regulatory protein DevR Virulence factor MUTATION: devR mutant is attenuated in guinea pigs (Malhotra et al., 2004). 14987770
1862 hspX from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212340 148661845 MRA_2046 YP_001283368.1 antigen Hsp20 Virulence factor MUTATION: hspX mutant is attenuated in murine macrophages and THP-1 cells (Yuan et al., 1998). 9689123
1863 fadD26 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212516 148662776 MRA_2956 YP_001284299.1 acyl-CoA synthetase Virulence factor MUTATION: fadD26 mutant is attenuated in mice (Infante et al., 2005). 15958066
1864 sigC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212564 148661883 MRA_2083 YP_001283406.1 RNA polymerase sigma factor SigC Virulence factor MUTATION: sigC mutant is attenuated in mice (Sun et al., 2004). 15049808
1865 mprA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212587 148660762 MRA_0988 YP_001282285.1 mycobacterial persistence regulator MrpA Virulence factor MUTATION: mprA mutant is attenuated in mice (Zahrt and Deretic, 2001). 11675502
1866 pepD from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212589 148660764 MRA_0990 YP_001282287.1 serine protease PepD Virulence factor MUTATION: pepD mutant has altered virulence in mouse model of infection (White et al., 2010). 20061478
1867 ino1 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212676 148659806 MRA_0049 YP_001281329.1 1L-myo-inositol-1-phosphate synthase Virulence factor MUTATION: ino1 mutant is attenuated in resting macrophages and guinea pigs (Movahedzadeh et al., 2004). 14763976
1868 trpD from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212696 148662009 MRA_2208 YP_001283532.1 anthranilate phosphoribosyltransferase Virulence factor MUTATION: trpD mutant is attenuated in mice (Smith et al., 2001). 11160012
1869 lipF from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212740 148663351 MRA_3527 YP_001284874.1 esterase LipF Virulence factor MUTATION: lipF mutant is attenuated in mice lungs (Camacho et al., 1999). 10564470
1870 pks1 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212915 148662793 MRA_2973 YP_001284316.1 putative polyketide synthase Pks1 Virulence factor MUTATION: pks1 mutant is attenuated in mice (Sirakova et al., 2003). 12730158
1871 pks15 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5212916 148662794 MRA_2974 YP_001284317.1 polyketide synthase Pks15 Virulence factor MUTATION: pks15 mutant is attenuated in mice (Sirakova et al., 2003). 12730158
1872 cysH from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213172 148662225 MRA_2416 YP_001283748.1 phosphoadenosine phosphosulfate reductase Virulence factor MUTATION: cysH mutant is attenuated in mice (Senaratne et al., 2006). 16553880
1873 secA2 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213460 148661627 MRA_1833 YP_001283150.1 preprotein translocase subunit SecA Virulence factor MUTATION: secA2 mutant is attenuated in mice (Braunstein et al., 2003). 12675804
1874 relA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213487 148662422 MRA_2612 YP_001283945.1 GTP pyrophosphokinase RelA Virulence factor MUTATION: Long-term survival of the relA mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anaerobic incubation than the wild-type virulent organism (Primm et al., 2000). 10940033
1875 drrC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213524 148662784 MRA_2964 YP_001284307.1 daunorubicin-dim ABC transporter permease protein DrrC Virulence factor MUTATION: drrC mutant is attenuated in mice (Camacho et al., 1999). 10564470
1876 fadD28 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213527 148662787 MRA_2967 YP_001284310.1 acyl-CoA synthetase Virulence factor MUTATION: fadD28 mutant is attenuated in mice (Cox et al., 1999). 10573420
1877 mmpL7 Mycobacterium tuberculosis H37Ra 5213528 148662788 MRA_2968 YP_001284311.1 transmembrane transport protein MmpL7 Virulence factor MUTATION: mmpL7 mutant is attenuated in mice (Cox et al., 1999). 10573420
1878 sodC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213568 148660197 MRA_0437 YP_001281720.1 superoxide dismutase Virulence factor MUTATION: sodC mutant is more susceptible to killing by activated murine macrophages than the wild type (Piddington et al., 2001). 11447176
1879 pks5 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213745 148661323 MRA_1539 YP_001282846.1 putative polyketide synthase pks5 Virulence factor MUTATION: pks5 mutant is attenuated in mice (Rousseau et al., 2003). 12855735
1880 sodA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5213873 148663714 MRA_3886 YP_001285237.1 superoxide dismutase Virulence factor MUTATION: sodA mutant is attenuated in mice (Edwards et al., 2001). 11751190
1881 mbtB from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214000 148662215 MRA_2406 YP_001283738.1 dihydroaeruginoic acid synthetase Virulence factor MUTATION: mbtB mutant is attenuated in macrophage like THP-1 cells (De et al., 2000). 10655517
1882 leuD from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214120 148662837 MRA_3016 YP_001284360.1 isopropylmalate isomerase small subunit Virulence factor MUTATION: leuD mutant is attenuated in mice (Hondalus et al., 2000). 10768986
1883 sigH from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214150 148663085 MRA_3263 YP_001284608.1 RNA polymerase sigma factor RpoE Virulence factor MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice (Kaushal et al., 2002). 12060776
1884 proC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214181 148660268 MRA_0507 YP_001281791.1 pyrroline-5-carboxylate reductase Virulence factor MUTATION: proC mutant is attenuated in mice (Smith et al., 2001). 11160012
1885 pknG from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214250 148660175 MRA_0416 YP_001281698.1 serine/threonine protein kinase Virulence factor MUTATION: pknG mutant is attenuated in mice (Cowley et al., 2004).
15186418
1886 prrA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214363 148660681 MRA_0910 YP_001282204.1 two component response transcriptional regulatory protein PrrA Virulence factor MUTATION: prrA mutant is attenuated in murine macrophages (Ewann et al., 2002). 11953357
1887 katG from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214412 148661716 MRA_1919 YP_001283239.1 catalase-peroxidase Virulence factor MUTATION: katG mutant is attenuated in mice and guinea pigs (Li et al., 1998). 9534978
1888 esxB from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214548 148663741 MRA_3913 YP_001285264.1 antigen EsxB Virulence factor MUTATION: esxB (CFP-10) mutant is attenuated in mice (Fortune et al., 2005). 16030141
1889 esxA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214549 148663742 MRA_3914 YP_001285265.1 early secretory antigenic target EsxA Virulence factor MUTATION: esxA (ESAT-6) mutant is attenuated in mice (Fortune et al., 2005). 16030141
1890 mycP1 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214557 148663750 MRA_3922 YP_001285273.1 membrane-anchored mycosin Mycp1 Virulence factor MUTATION: mycP1 is attenuated in chronic infection of mice (Ohol et al., 2010). 20227664
1891 fbpA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214567 148663672 MRA_3844 YP_001285195.1 secreted antigen 85-A FbpA Virulence factor MUTATION: fbpA mutant is attenuated in mice (Copenhaver et al., 2004). 15557632
1892 ahpC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214581 148662263 MRA_2455 YP_001283786.1 AhpC Virulence factor MUTATION: ahpC mutant has decreased survival in unactivated macrophages compared to the wild type (Master et al., 2002). 12368447
1893 panD from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214616 148663465 MRA_3640 YP_001284988.1 aspartate alpha-decarboxylase Virulence factor MUTATION: panCD mutant is attenuated in mice (Sambandamurthy et al., 2002). 12219086
1894 panC from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214617 148663466 MRA_3641 YP_001284989.1 pantoate--beta-alanine ligase Virulence factor MUTATION: panCD mutant is attenuated in mice (Sambandamurthy et al., 2002). 12219086
1895 ompA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214708 148660677 MRA_0906 YP_001282200.1 outer membrane protein A Virulence factor MUTATION: ompA mutant is impaired in its ability to grow in macrophages and in normal mice, although it was as virulent as the wild type in mice that lack T cells (Raynaud et al., 2002). 12366842
1896 lspA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214891 148661335 MRA_1551 YP_001282858.1 lipoprotein signal peptidase Virulence factor MUTATION: lspA mutant is attenuated in mice (Rampini et al., 2008). 18832305
1897 mmpL8 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5214944 148663691 MRA_3863 YP_001285214.1 transmembrane transport protein MmpL8 Virulence factor MUTATION: mmpL8 mutant is attenuated in mice (Converse et al., 2003). 12724526
1898 yrbE1B from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215107 148659932 MRA_0176 YP_001281455.1 conserved hypothetical integral membrane protein YrbE1b Virulence factor MUTATION: yrbE1B mutant is attenuated in mice (Gioffré et al., 2005). 15804490
1899 phoP from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215306 148660534 MRA_0767 YP_001282057.1 putative two component system response transcriptional positive regulator PhoP Virulence factor MUTATION: phoP mutant is attenuated in mice (Pérez et al., 2001). 11454210
1900 ilvB1 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215324 148662854 MRA_3033 YP_001284377.1 acetolactate synthase 1 catalytic subunit Virulence factor MUTATION: ilvB1 mutant is attenuated in mice (Awasthy et al., 2009). 19542000
1901 sigE from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215382 148661008 MRA_1230 YP_001282531.1 RNA polymerase sigma factor SigE Virulence factor MUTATION: sigE mutant is unable to grow in unactivated human and murine macrophages and is more susceptible to killing by activated macrophages than the wild type (Manganelli et al., 2001). 11489128
1902 pks10 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215526 148661456 MRA_1671 YP_001282979.1 putative chalcone synthase Pks10 Virulence factor MUTATION: pks10 mutant is attenuated in mice (Sirakova et al., 2003). 12730158
1903 pks7 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215527 148661457 MRA_1672 YP_001282980.1 putative polyketide synthase Pks7 Virulence factor MUTATION: pks7 mutant is attenuated in mice (Rousseau et al., 2003). 12855735
1904 moeB1 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215558 148663066 MRA_3244 YP_001284589.1 molybdopterin biosynthesis-like protein MoeZ Virulence factor MUTATION: moeB1 mutant is attenuated in mice (MacGurn and Cox, 2007). 17353284
1905 icl from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215578 148660233 MRA_0473 YP_001281756.1 isocitrate lyase Icl Virulence factor MUTATION: icl mutant is attenuated in activated macrophages (McKinney et al., 2000). 10963599
1906 pcaA from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215613 148660236 MRA_0476 YP_001281759.1 mycolic acid synthase PcaA Virulence factor MUTATION: pcaA mutant is attenuated in mice (Glickman et al., 2000). 10882107
1907 fadD33 from Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra 5215636 148661134 MRA_1353 YP_001282657.1 acyl-CoA synthetase Virulence factor MUTATION: fadD33 mutant is attenuated in mice (Rindi et al., 2002). 12480891
4915 lysA Mycobacterium tuberculosis H37Rv 886960 15608433 Rv1293 BX842576 NP_215809 diaminopimelate decarboxylase LysA Virulence factor MUTATION: lysA mutant is markedly attenuated in SCID mice, and is strongly attenuated in mice when in combination with a secA2 mutation (Hinchey et al., 2011). 21264335
4916 mce-2 Mycobacterium tuberculosis CDC1551 925014 15839991 MT0618 AE000516 NP_335028 virulence factor Virulence factor MUTATION: a mce-2 mutant is a strongly attenuated in BALB/c mice (Aguilar et al., 2006). 16388878
4917 mce-3 Mycobacterium tuberculosis CDC1551 923491 15841441 MT2018 AE000516 NP_336478 virulence factor Virulence factor MUTATION: mce-3 mutant is strongly attenuated in BALB/c mice (Aguilar et al., 2006). 16388878