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Found 52 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
2827 ompP2 from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3429565 68248747 NTHI0225 YP_247859.1 OMP P2 Virulence factor MUTATION: the introduction of functional NTHI ompP2 gene into the avirulent Hib ompP2 mutant restored the virulence of this strain to wild-type levels (Sanders et al., 1993). P2 mutants are unable to produce detectable bacteremia in infant rats (Cope et al., 1990). 7689543 2169463
2828 dam from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3429634 68248814 NTHI0307 YP_247926.1 deoxyadenosyl-methyltransferase; DNA adenine methyltransferase; M.HindIV Virulence factor MUTATION: dam mutants is attenuated in invasion of of human brain microvascular endothelial cells (HBMECs) and human respiratory epithelial cells (NCI-H292) (Watson et al., 2004). 15228541
2829 lgtC Haemophilus influenzae 86-028NP 3429690 68248865 NTHI0365 CP000057 YP_247977 UDP-galactose--lipooligosaccharide galactosyltransferase Virulence factor MUTATION: lgtC mutant is attenuated in infant rat model (Hood et al., 1996). 8855319
2830 oapA from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3429769 68248935 NTHI0448 YP_248047.1 opacity associated protein OapA Virulence factor MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type (Prasadarao et al., 1999). 10417187
2831 lic3A Haemophilus influenzae 86-028NP 3429791 68248957 NTHI0472 CP000057 YP_248069 CMP-Neu5Ac--lipooligosaccharide alpha 2-3 sialyltransferase Virulence factor MUTATION: lic3A mutant is attenuated in chinchilla (Bouchet et al., 2003). 12855765
2832 accA from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3429845 68249008 NTHI0528 YP_248120.1 acetyl-CoA carboxylase carboxyltransferase subunit alpha Virulence factor MUTATION: accA mutant is attenuated in rats (Herbert et al., 2002). 12473436
2833 rpoE from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3430027 68249183 NTHI0719 YP_248295.1 Sigma-24 Virulence factor MUTATION: ropE mutants are unable to survive intracellularly in macrophages (Craig et al., 2002). 11796603
2834 pgmB Haemophilus influenzae 86-028NP 3430211 68249340 NTHI0899 CP000057 YP_248452 phosphoglucomutase Virulence factor MUTATION: pgmB mutant is had reduced adherence and invasion of human bronchial epithelial cells (16HBE14) (Swords et al., 2000). 10931302
2835 dsbA from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3430315 68249440 NTHI1012 YP_248552.1 thiol:disulfide interchange protein DsbA Virulence factor MUTATION: dsbA mutant is attenuated in mice (Rosadini et al., 2008). 18212083
2836 hbpA Haemophilus influenzae 86-028NP 3430322 68249447 NTHI1021 CP000057 YP_248559 heme-binding protein A Virulence factor MUTATION: hbpA mutant is attenuated in mice (Rosadini et al., 2008). 18212083
2837 hktE from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3430392 68249515 NTHI1099 YP_248627.1 catalase Virulence factor MUTATION: ktkE mutant has attenuated virulence in interperitoneal infection in infant rats (Bishai et al., 1994). 7927766
2838 licD Haemophilus influenzae 86-028NP 3430833 68249945 NTHI1594 CP000057 YP_249057 phosphorylcholine transferase Virulence factor MUTATION: licD mutant is more rapidly cleared in mouse pulmonary infection than the wild type (Pang et al., 2008). 18347044
2839 siaB Haemophilus influenzae 86-028NP 3431148 68250197 NTHI1891 CP000057 YP_249309 acylneuraminate cytidylyltransferase Virulence factor MUTATION: siaB mutant is attenuated in chinchillas (Bouchet et al., 2003). 12855765
2840 tehB from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3431152 68250201 NTHI1895 YP_249313.1 tellurite resistance protein TehB Virulence factor MUTATION: tehB mutant is attenuated in rats (Whitby et al., 2010). 20075041
2841 ptsI from Haemophilus influenzae 86-028NP Haemophilus influenzae 86-028NP 3431268 68250314 NTHI2021 YP_249426.1 phosphotransferase system, enzyme I Virulence factor MUTATION: ptsI is attenuated in mice (Kok et al., 2003). 12949188
2842 HI0364 Haemophilus influenzae Rd KW20 949374 16272312 HI0364 L42023 NP_438525 penicillin-binding protein 7 Virulence factor MUTATION: HI0364 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2843 oapA from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 949442 16272282 HI0330 NP_438494.1 opacity associated protein Virulence factor MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type (Prasadarao et al., 1999). 10417187
2844 HI1018 Haemophilus influenzae Rd KW20 949460 0 HI1018 - pseudo Virulence factor MUTATION: HI1018 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2845 accA from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 949505 16272355 HI0406 NP_438568.1 acetyl-CoA carboxylase carboxyltransferase subunit alpha Virulence factor MUTATION: accA mutant is attenuated in rats (Herbert et al., 2002). 12473436
2846 nudC Haemophilus influenzae Rd KW20 949531 16272380 HI0432 L42023 NP_438593 NADH pyrophosphatase Virulence factor MUTATION: nudC mutant is attenuated in rats (Herbert et al., 2002). 12473436
2847 HI1245 Haemophilus influenzae Rd KW20 949562 16273164 HI1245 L42023 NP_439401 malic enzyme Virulence factor MUTATION: HI1245 mutant is attenuated in rats (Herbert et al., 2002) 12473436
2848 fdx-2 Haemophilus influenzae Rd KW20 949590 16272471 HI0527 L42023 NP_438685 ferredoxin Virulence factor MUTATION: fdx-2 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2849 oapA from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 949701 16272604 HI0661 NP_438821.1 hemoglobin-binding protein Virulence factor MUTATION: oapA mutant has significantly reduced binding to Chang epithelial cells than the wild type (Prasadarao et al., 1999). 10417187
2850 HI0700 Haemophilus influenzae Rd KW20 949725 16272641 HI0700 L42023 NP_438859 hypothetical protein Virulence factor MUTATION: HI0700 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2851 arcA Haemophilus influenzae Rd KW20 949839 16272824 HI0884 L42023 NP_439045 two-component response regulator Virulence factor MUTATION: arcA mutant is attenuated in mice (De et al., 2003). 12496162
2852 obgE Haemophilus influenzae Rd KW20 949885 16272817 HI0877 L42023 NP_439038 GTPase ObgE Virulence factor MUTATION: obgE mutant is attenuated in rats (Herbert et al., 2002). 12473436
2853 emrA Haemophilus influenzae Rd KW20 949904 16272836 HI0898 L42023 NP_439059 multidrug resistance protein A Virulence factor MUTATION: emrA mutant is attenuated in rats (Herbert et al., 2002). 12473436
2854 hktE from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 949926 16272865 HI0928 NP_439088.1 catalase Virulence factor MUTATION: htkE mutant has attenuated virulence in interperitioneal infection of infant rats (Bishai et al., 1994). 7927766
2855 tehB from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 949980 16273190 HI1275 NP_439428.1 tellurite resistance protein TehB Virulence factor MUTATION: tehB mutant is attenuated in rats (Whitby et al., 2010). 20075041
2856 pmbA Haemophilus influenzae Rd KW20 950115 16273077 HI1152 L42023 NP_439310 hypothetical protein Virulence factor MUTATION: pmbA mutant is attenuated in rats (Herbert et al., 2002). 12473436
2857 ompA Haemophilus influenzae Rd KW20 950124 16273088 HI1164 L42023 NP_439322 outer membrane protein P5 Virulence factor MUTATION: ompA mutant had reduced adherence to human oropharyngeal cells in vitro, augmented clearance from the tympanum post-transbullar inoculation, and significantly reduced induction of OM post-intranasal inoculation in a chinchilla model compared to the wild type (Sirakova et al., 1994). 7909539
2858 dsbA from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 950165 30995432 HI1215 NP_439371.2 thiol-disulfide interchange protein Virulence factor MUTATION: dsbA mutant is attenuated in mice (Rosadini et al., 2008). 18212083
2859 HI0561 Haemophilus influenzae Rd KW20 950224 16272504 HI0561 L42023 NP_438718 hypothetical protein Virulence factor MUTATION: HI0561 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2860 HI1459 Haemophilus influenzae Rd KW20 950350 30995451 HI1459 L42023 NP_439610 RNA polymerase sigma factor Virulence factor MUTATION: HI1459 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2861 parE Haemophilus influenzae Rd KW20 950390 16273428 HI1528 L42023 NP_439677 DNA topoisomerase IV subunit B Virulence factor MUTATION: parE mutant is attenuated in rats (Herbert et al., 2002). 12473436
2862 licA Haemophilus influenzae Rd KW20 950399 16273437 HI1537 L42023 NP_439686 lic-1 operon protein Virulence factor MUTATION: licA mutant is attenuated in rats (Herbert et al., 2002). 12473436
2863 HI1598 Haemophilus influenzae Rd KW20 950454 16273488 HI1598 L42023 NP_439740 hypothetical protein Virulence factor MUTATION: HI1598 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2864 HI1368 Haemophilus influenzae Rd KW20 950673 16273278 HI1368 L42023 NP_439519 putative zinc protease Virulence factor MUTATION: HI1368 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2865 HI0936 Haemophilus influenzae Rd KW20 950731 16272873 HI0936 L42023 NP_439096 cytochrome C-type biogenesis Virulence factor MUTATION: HI0936 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2866 lctP Haemophilus influenzae Rd KW20 950748 16273137 HI1218 L42023 NP_439374 L-lactate permease Virulence factor MUTATION: lctP mutant is attenuated in rats (Herbert et al., 2002). 12473436
2867 alaS Haemophilus influenzae Rd KW20 950776 16272755 HI0814 L42023 NP_438974 alanyl-tRNA synthetase Virulence factor MUTATION: alaS mutant is attenuated in rats (Herbert et al., 2002). 12473436
2868 rpoE from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 950801 16272571 HI0628 NP_438788.1 RNA polymerase sigma factor RpoE Virulence factor MUTATION: ropE mutants are unable to survive intracellularly in macrophages (Craig et al., 2002). 11796603
2869 dsbB Haemophilus influenzae Rd KW20 950809 16272376 HI0428 L42023 NP_438589 disulfide bond formation protein B Virulence factor MUTATION: dsbB mutant is attenuated in rats (Herbert et al., 2002). 12473436
2870 HI1677 Haemophilus influenzae Rd KW20 950862 16273564 HI1677 L42023 NP_439819 iron-sulfur cluster repair di-iron protein Virulence factor MUTATION: Compared to the wild-type strain, the ytfE (HI1677) mutant exhibited decreased survival when exposed to macrophages, a defect that was more pronounced after prior stimulation of macrophages with IFN-gamma or lipopolysaccharide. Complementation restored survival of the mutant to the level in the parental strain (Harrington et al., 2009). 19289513
2871 ptsI from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 950872 16273599 HI1712 NP_439854.1 phosphoenolpyruvate-protein phosphotransferase Virulence factor MUTATION: ptsl mutant is attenuated in mice (Kok et al., 2003). 12949188
2872 HI1732 Haemophilus influenzae Rd KW20 950878 0 HI1732 - - Virulence factor MUTATION: HI1732 mutant is attenuated in rats (Herbert et al., 2002). 12473436
2873 metB Haemophilus influenzae Rd KW20 950982 16272060 HI0086 L42023 NP_438259 cystathionine gamma-synthase Virulence factor MUTATION: metB mutant is attenuated in rats (Herbert et al., 2002). 12473436
2874 afuB Haemophilus influenzae Rd KW20 951037 16272097 HI0129 L42023 NP_438299 ferric transport system permease-like protein Virulence factor MUTATION: afuB mutant is attenuated in rats (Herbert et al., 2002). 12473436
2875 ompP2 Haemophilus influenzae Rd KW20 951048 16272106 HI0139 L42023 NP_438308 outer membrane protein P2 Virulence factor MUTATION: the introduction of functional NTHI ompP2 gene into the avirulent Hib ompP2 mutant restored the virulence of this strain to wild-type levels (Sanders et al., 1993). P2 mutants are unable to produce detectable bacteremia in infant rats (Cope et al., 1990). 7689543 2169463
2876 dam from Haemophilus influenzae Rd KW20 Haemophilus influenzae Rd KW20 951117 16272172 HI0209 NP_438378.1 DNA adenine methylase Virulence factor MUTATION: dam mutants is attenuated in invasion of of human brain microvascular endothelial cells (HBMECs) and human respiratory epithelial cells (NCI-H292) (Watson et al., 2004). 15228541
4863 LPS Haemophilus influenzae Virulence factor MUTATION: isogenic sialic acid-deficient LPS mutants (disrupted sialyltransferase or CMP-acetylneuraminic acid synthetase genes) were profoundly attenuated in chinchillas (Bouchet et al., 2003). 12855765
4887 type b polysaccharide capsule Haemophilus influenzae Virulence factor MUTATION: mutations in the genes hcsA and/or hcsB resulted in diminished polysaccharide b capsule, and were attenuated in neonatal mice (Sukupolvi-Petty et al., 2006). 16707679