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Found 6 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4905 E(rns) Classical swine fever virus - Brescia 130457 Genome polyprotein Virulence factor MUTATION: An N269A/Q mutation in the E(rns) protein created an attenuated mutant in swine (Sainz et al., 2008). 17904607
4906 E1 Classical swine fever virus - Brescia 325460 325461 AAA43843.1 protein precursor Virulence factor MUTATION: An N to A amino acid substitution was made in the N594 site of the E1 glycoprotein, resulting in attenuation of the virus in swine (Fernandez-Sainz et al., 2009). 19203774
4960 E2 Classical swine fever virus 920146 12657942 PestiV2gp1 AF326963 NP_075354 polyprotein Virulence factor MUTATION: A E2 mutant in Classical swine fever virus is attenuated in pigs (Maurer et al., 2005). 15837238
5088 P7 27885149 nonstructural protein p7 Virulence factor Using reverse genetics, partial in-frame deletions of p7 were deleterious for virus growth, demonstrating that CSFV p7 function is critical for virus production in cell cultures. A panel of recombinant mutant CSFVs was created using alanine scanning mutagenesis of the p7 gene harboring sequential three- to six-amino-acid residue substitutions spanning the entire protein. These recombinant viruses allowed the identification of the regions within p7 that are critical for virus production in vitro. In vivo, some of these viruses were partially or completely attenuated in swine relative to the highly virulent parental CSFV Brescia strain, indicating a significant role of p7 in CSFV virulence (Gladue et al., 2012). 22496228
5096 N-Pro 27885143 N-Pro Virulence factor Here, for the moderately virulent CSFV strain Alfort/187 as well as for the highly virulent strain Eystrup we show that the respective N(pro)-deleted viruses are attenuated. Vaccination of pigs with either of the two deletion mutants resulted in the induction of a strong antibody response. Animals were protected against challenge with a lethal dose of highly virulent CSFV indicating that N(pro) deletion mutants are excellent candidates for a modified live virus vaccine. (Mayer et al., 2004)
14670312
5113 NS4B 27885153 nonstructural protein NS4B Virulence factor NS4B.VGIv showed an attenuated phenotype in swine, displaying reduced replication in the oronasal cavity and limited spread from the inoculation site to secondary target organs (Fernandez-Sainz et al., 2009). 19203774