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Found 7 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4893 US8 Bovine herpesvirus 1 1487407 9629888 BoHV1_gp42 AJ004801 NP_045372 envelope glycoprotein E Virulence factor MUTATION: Strain A of the virus has a mutation in the glycoprotein E gene, and is avirulent in calves (Kaashoek et al., 1994).
MUTATION: the Za strain of BHV1 is attenuated by a deletion of the gE gene and is used as a live attenuated vaccine (Kaashoek et al., 1995).
8023552 7793128
4953 UL23 Bovine herpesvirus 1 1487380 9629852 BoHV1_gp21 Z78205 NP_045336 thymidine kinase Virulence factor MUTATION: A thymidine kinase-deficient mutant (B8-D53) showed no detectable thymidine kinase-inducing activity and was attenuated in calves (Kit et al., 1985). 2994602
5054 gE 195593051 195593052 ACG50670.1 truncated glycoprotein E Virulence factor MUTATION: the gE and gE/TK deletion mutants were avirulent (van et al., 1994). 8077929
5055 UL47 Bovine herpesvirus 1 1487395 9629828 BoHV1_gp07 M84469 NP_045312 tegument protein VP13/14 Virulence factor The U(L)47 deletion mutant exhibited reduced plaque size and more than 100-fold decrease in intracellular and extracellular viral titers in cultured cells. the U(L)47 gene product was indispensable for BHV-1 replication in vivo, since no clinical manifestations or viral shedding were detected in the U(L)47 deletion mutant-infected calves, and the virus failed to induce significant levels of humoral and cellular immunity. (Lobanov et al., 2010) 19864376
5056 BICP0 Bovine herpesvirus 1 1487364 9629879 BoHV1_gp35 M84465 NP_045363 ubiquitin E3 ligase ICP0 Virulence factor During acute infection of calves, levels of infectious virus were 2 to 3 logs lower in ocular or nasal swabs with 51g than with 51gR. Calves latently infected with the 51g mutant did not reactivate from latency because virus shedding did not occur in ocular or nasal cavities. (Saira et al., 2008) 18842710
5057 US4 291500676 291500677 ADE08263.1 glycoprotein G Virulence factor Glycoprotein gC, gG, gI and gE single deletion mutants, a gI/gE double deletion mutant and a gE frame-shift mutant were made. The virulence and immunogenicity of these mutants were evaluated in specific-pathogen-free calves. Except for the gC deletion mutant, all mutants were significantly less virulent than the parental wild-type (wt) BHV1 strain Lam. (Kaashoek et al., 1994) 8023552
5058 US7 291500678 291500679 ADE08264.1 glycoprotein I Virulence factor Glycoprotein gC, gG, gI and gE single deletion mutants, a gI/gE double deletion mutant and a gE frame-shift mutant were made. The virulence and immunogenicity of these mutants were evaluated in specific-pathogen-free calves. Except for the gC deletion mutant, all mutants were significantly less virulent than the parental wild-type (wt) BHV1 strain Lam. (Kaashoek et al., 1994) 8023552