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Found 122 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
4033 yibK Actinobacillus pleuropneumoniae L20 4848512 126207549 APL_0061 CP000569 YP_001052774 putative tRNA/rRNA methyltransferase Virulence factor MUTATION: yibK mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4034 dnaK from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848587 126209366 APL_1906 YP_001054591.1 molecular chaperone DnaK Virulence factor MUTATION: dnaK mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4035 nqrA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848604 126207638 APL_0150 YP_001052863.1 Na(+)-translocating NADH-quinone reductase subunit A Virulence factor MUTATION: ngrA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4036 aroA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848647 126208179 APL_0699 YP_001053404.1 3-phosphoshikimate 1-carboxyvinyltransferase Virulence factor MUTATION: aroA mutant is attenuated in pigs (Garside et al., 2002). 12027598
4037 fur from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848648 126208686 APL_1218 YP_001053911.1 ferric uptake regulation protein Virulence factor MUTATION: fur mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4038 moaA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848653 126208170 APL_0690 YP_001053395.1 molybdenum cofactor biosynthesis protein A Virulence factor MUTATION: moaA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4039 pntB from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848714 126208317 APL_0841 YP_001053542.1 pyridine nucleotide transhydrogenase Virulence factor MUTATION: pntB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4040 dksA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848733 126207663 APL_0175 YP_001052888.1 DnaK suppressor protein Virulence factor MUTATION: dksA mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4041 napB from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848740 126208890 APL_1426 YP_001054115.1 nitrate reductase cytochrome c-type subunit Virulence factor MUTATION: napB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4042 ilvI from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848759 126208207 APL_0727 YP_001053432.1 acetolactate synthase 3 catalytic subunit Virulence factor MUTATION: ilvl mutant is attenuated in pigs (Subashchandrabose et al., 2009). 19703979
4043 mrp from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848795 126208474 APL_1000 YP_001053699.1 putative ATPase Virulence factor MUTATION: mrp mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4044 htpG from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848844 126208461 APL_0987 YP_001053686.1 heat shock protein 90 Virulence factor MUTATION: htpG mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4045 thrC from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848887 126208963 APL_1499 YP_001054188.1 threonine synthase Virulence factor MUTATION: thrC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4046 recR from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848935 126207562 APL_0074 YP_001052787.1 recombination protein RecR Virulence factor MUTATION: recR mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4047 frpB from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4848963 126207764 APL_0276 YP_001052989.1 iron-regulated outer membrane protein B Virulence factor MUTATION: frpB mutant is avirulent in pigs (Buettner et al., 2009). 19343711
4048 cpxD from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849025 126209046 APL_1582 YP_001054271.1 capsule polysaccharide export protein Virulence factor MUTATION: cpxD mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4049 cpxC from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849026 126209047 APL_1583 YP_001054272.1 capsule polysaccharide export inner-membrane protein Virulence factor MUTATION: cpxC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4050 pnp from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849054 126208059 APL_0577 YP_001053284.1 polynucleotide phosphorylase/polyadenylase Virulence factor MUTATION: pnp mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4051 irp from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849145 126208395 APL_0919 YP_001053620.1 iron-regulated outer membrane protein Virulence factor MUTATION: irp mutant is attenuated in competitive index experiment in pig infection model (Subashchandrabose et al., 2009). 19703979
4052 fkpA Actinobacillus pleuropneumoniae L20 4849158 126209104 APL_1640 CP000569 YP_001054329 putative FKBP-type peptidyl-prolyl cis-trans isomerase Virulence factor MUTATION: fkpA mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4053 argG from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849166 126207906 APL_0422 YP_001053131.1 argininosuccinate synthase Virulence factor MUTATION: argG mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4054 dmsA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849184 126209138 APL_1674 YP_001054363.1 anaerobic dimethyl sulfoxide reductase chain A precursor Virulence factor MUTATION: dmsA mutant is attenuated in pigs (Baltes et al., 2003). 14638764
4055 corC from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849211 126207856 APL_0372 YP_001053081.1 magnesium and cobalt efflux protein Virulence factor MUTATION: corC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4056 mglA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849247 126208883 APL_1419 YP_001054108.1 galactose/methyl galaxtoside transporter ATP-binding protein Virulence factor MUTATION: mglA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4057 tbpA Actinobacillus pleuropneumoniae L20 4849278 126209031 APL_1567 CP000569 YP_001054256 transferrin-binding protein 1 Tbp1 Virulence factor MUTATION: tbpA mutant is attenuated in pigs (Baltes et al., 2002). 12007819
4058 dnaJ from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849429 126209365 APL_1905 YP_001054590.1 chaperone protein DnaJ Virulence factor MUTATION: dnaJ mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4059 galU from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849515 126208131 APL_0651 YP_001053356.1 UTP--glucose-1-phosphate uridylyltransferase Virulence factor MUTATION: galU mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4060 aroQ from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849643 126209324 APL_1862 YP_001054549.1 3-dehydroquinate dehydratase Virulence factor MUTATION: aroQ mutant is attenuated in pigs (Ingham et al., 2002). 11731178
4061 tig from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849723 126208971 APL_1507 YP_001054196.1 trigger factor Virulence factor MUTATION: tig mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4062 lpdA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849746 126208249 APL_0771 YP_001053474.1 dihydrolipoamide dehydrogenase Virulence factor MUTATION: lpdA mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4063 hgbA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849777 126208521 APL_1047 YP_001053746.1 hemoglobin-binding protein A precursor Virulence factor MUTATION: hgbA mutant is attenuated in pigs (Shakarji et al., 2006). 16699590
4064 exbB Actinobacillus pleuropneumoniae L20 4849793 126209034 APL_1570 CP000569 YP_001054259 biopolymer transport ExbB protein Virulence factor MUTATION: exbB mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4065 hemA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849853 126207888 APL_0404 YP_001053113.1 glutamyl-tRNA reductase Virulence factor MUTATION: hemA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4066 apxIC Actinobacillus pleuropneumoniae L20 4849898 126208909 APL_1445 YP_001054134.1 RTX-I toxin-activating lysine-acyltransferase ApxIC Virulence factor MUTATION: apxlC mutant is attenuated in mice (Xu et al., 2007). 18062275
4067 guaA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849920 126208074 APL_0592 YP_001053299.1 GMP synthase Virulence factor MUTATION: guaA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4068 prc from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849922 126207608 APL_0120 YP_001052833.1 carboxy-terminal protease Virulence factor MUTATION: prc mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4069 lon from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849930 126207860 APL_0376 YP_001053085.1 ATP-dependent protease La Virulence factor MUTATION: lon mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4070 hemE from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849940 126207600 APL_0112 YP_001052825.1 uroporphyrinogen decarboxylase Virulence factor MUTATION: hemE mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4071 dsbA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4849992 126209330 APL_1868 YP_001054555.1 Thiol:disulfide interchange protein dsbA precursor Virulence factor MUTATION: dsbA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4072 hupA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850001 126207602 APL_0114 YP_001052827.1 DNA-binding protein HU Virulence factor MUTATION: hupA mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4073 atpG from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850085 126209111 APL_1647 YP_001054336.1 F0F1 ATP synthase subunit gamma Virulence factor MUTATION: atpG mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4074 rpmF from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850127 126208850 APL_1386 YP_001054075.1 50S ribosomal protein L32 Virulence factor MUTATION: rpmF mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4075 znuA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850149 126208904 APL_1440 YP_001054129.1 high-affinity zinc transporter periplasmic component Virulence factor MUTATION: znuA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4076 atpA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850203 126209112 APL_1648 YP_001054337.1 F0F1 ATP synthase subunit alpha Virulence factor MUTATION: atpA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4077 cpxB from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850217 126209048 APL_1584 YP_001054273.1 capsule polysaccharide export inner-membrane protein Virulence factor MUTATION: cpxB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4078 apxIA Actinobacillus pleuropneumoniae L20 4850247 126208908 APL_1444 YP_001054133.1 RTX-I toxin determinant A Virulence factor MUTATION: apxIA mutant is attenuated in mice (Xu et al., 2006). 16930871
4079 visC from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850274 126207817 APL_0333 YP_001053042.1 putative monooxygenase family protein Virulence factor MUTATION: visC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4080 hlyX from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850318 126208136 APL_0656 YP_001053361.1 fumarate/nitrate reduction transcriptional regulator Virulence factor MUTATION: hlyX mutant is attenuated in pigs (Baltes et al., 2005). 16040973
4081 tbpB Actinobacillus pleuropneumoniae L20 4850335 126209032 APL_1568 CP000569 YP_001054257 transferrin-binding protein Virulence factor MUTATION: tbpB mutant is attenuated in pigs (Baltes et al., 2002). 12007819
4082 atpH from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850346 126209113 APL_1649 YP_001054338.1 F0F1 ATP synthase subunit delta Virulence factor MUTATION: atpH mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4083 luxS from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850390 126208684 APL_1216 YP_001053909.1 S-ribosylhomocysteinase Virulence factor MUTATION: luxS mutant is attenuated in mice (Li et al., 2008). 18585450
4084 arcA from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850431 126207536 APL_0048 YP_001052761.1 two-component response regulator Virulence factor MUTATION: arcA mutant is attenuated in pigs (Buettner et al., 2008). 17881160
4085 rpoE from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850464 126207878 APL_0394 YP_001053103.1 RNA polymerase sigma factor RpoE Virulence factor MUTATION: rpoE mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4086 prfC from Actinobacillus pleuropneumoniae L20 Actinobacillus pleuropneumoniae L20 4850473 126207518 APL_0030 YP_001052743.1 peptide chain release factor 3 Virulence factor MUTATION: prfC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4104 rpmF from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850734 165976811 APJL_1404 YP_001652404.1 50S ribosomal protein L32 Virulence factor MUTATION: rpmF mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4105 thrC from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850813 165976927 APJL_1524 YP_001652520.1 threonine synthase Virulence factor MUTATION: thrC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4106 znuA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850850 165976875 APJL_1472 YP_001652468.1 high-affinity zinc transporter periplasmic component Virulence factor MUTATION: znuA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4107 visC from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850858 165975791 APJL_0349 YP_001651384.1 monoxygenase Virulence factor MUTATION: visC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4108 rpoE from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850859 165975855 APJL_0415 YP_001651448.1 RNA polymerase sigma factor RpoE Virulence factor MUTATION: rpoE mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4109 atpA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850894 165977084 APJL_1681 YP_001652677.1 F0F1 ATP synthase subunit alpha Virulence factor MUTATION: atpA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4110 atpH from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850906 165977085 APJL_1682 YP_001652678.1 F0F1 ATP synthase subunit delta Virulence factor MUTATION: atpH mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4111 hupA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850919 165975570 APJL_0115 YP_001651163.1 DNA-binding protein HU Virulence factor MUTATION: hupA mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4112 prc from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5850978 165975576 APJL_0121 YP_001651169.1 carboxy-terminal protease Virulence factor MUTATION: prc mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4113 napB from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851075 165976861 APJL_1458 YP_001652454.1 nitrate reductase cytochrome c-type subunit Virulence factor MUTATION: napB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4114 mglA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851167 165976854 APJL_1451 YP_001652447.1 galactose/methyl galaxtoside transporter ATP-binding protein Virulence factor MUTATION: mglA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4115 dksA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851169 165975631 APJL_0176 YP_001651224.1 dosage-dependent DnaK suppressor protein Virulence factor MUTATION: dksA mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4116 dmsA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851276 165977108 APJL_1705 YP_001652701.1 anaerobic dimethyl sulfoxide reductase chain A precursor Virulence factor MUTATION: dmsA mutant is attenuated in pigs (Baltes et al., 2003). 14638764
4117 frpB from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851335 165975732 APJL_0286 YP_001651325.1 iron-regulated outer membrane protein Virulence factor MUTATION: frpB mutant is avirulent in pigs (Buettner et al., 2009). 19343711
4118 yfeB Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851399 165975728 APJL_0280 CP000687 YP_001651321 iron (chelated) transporter, ATP-binding protein Virulence factor MUTATION: yfeB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4119 lppB Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851473 165977377 APJL_1978 CP000687 YP_001652970 outer membrane antigenic lipoprotein B Virulence factor MUTATION: lppB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4120 prfC from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851529 165975488 APJL_0031 YP_001651081.1 peptide chain release factor 3 Virulence factor MUTATION: prfC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4121 hemE from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851531 165975568 APJL_0113 YP_001651161.1 uroporphyrinogen decarboxylase Virulence factor MUTATION: hemE mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4122 nqrA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851670 165975606 APJL_0151 YP_001651199.1 Na(+)-translocating NADH-quinone reductase subunit A Virulence factor MUTATION: nqrA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4123 argG from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851696 165975881 APJL_0447 YP_001651474.1 argininosuccinate synthase Virulence factor MUTATION: argG mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4124 tig from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851732 165976936 APJL_1533 YP_001652529.1 trigger factor Virulence factor MUTATION: tig mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4125 fur from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851786 165976638 APJL_1231 YP_001652231.1 ferric uptake regulation protein Virulence factor MUTATION: fur mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4126 luxS from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851794 165976636 APJL_1229 YP_001652229.1 S-ribosylhomocysteinase Virulence factor MUTATION: luxS mutant is attenuated in mice (Li et al., 2008). 18585450
4127 cpxD from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851863 165977018 APJL_1615 YP_001652611.1 HexD, capsule biosynthetic locus protein Virulence factor MUTATION: cpxD mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4128 corC from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851868 165975832 APJL_0390 YP_001651425.1 magnesium and cobalt efflux protein Virulence factor MUTATION: corC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4129 cpxB from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851869 165977020 APJL_1617 YP_001652613.1 capsule polysaccharide export transport system permease protein Virulence factor MUTATION: cpxB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4130 pnp from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851945 165975991 APJL_0570 YP_001651584.1 polynucleotide phosphorylase/polyadenylase Virulence factor MUTATION: pnp mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4131 cpxC from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851954 165977019 APJL_1616 YP_001652612.1 capsule polysaccharide export transport system permease protein Virulence factor MUTATION: cpxC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4132 guaA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5851973 165976006 APJL_0585 YP_001651599.1 GMP synthase Virulence factor MUTATION: guaA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4133 aroQ from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852036 165977306 APJL_1905 YP_001652899.1 3-dehydroquinate dehydratase Virulence factor MUTATION: aroQ mutant is attenuated in pigs (Ingham et al., 2002). 11731178
4134 hemA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852041 165975865 APJL_0425 YP_001651458.1 glutamyl-tRNA reductase Virulence factor MUTATION: hemA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4135 dsbA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852086 165977312 APJL_1911 YP_001652905.1 thiol:disulfide interchange protein Virulence factor MUTATION: dsbA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4136 hgbA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852221 165976472 APJL_1065 YP_001652065.1 hemoglobin and hemoglobin-haptoglobin-binding protein 4 precursor Virulence factor MUTATION: hgbA mutant is attenuated in pigs (Shakarji et al., 2006). 16699590
4137 mrp from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852278 165976425 APJL_1018 YP_001652018.1 putative ATPase Virulence factor MUTATION: mrp mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4138 htpG from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852294 165976413 APJL_1004 YP_001652006.1 heat shock protein 90 Virulence factor MUTATION: htpG mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4139 irp from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852390 165976339 APJL_0930 YP_001651932.1 iron-regulated outer membrane protein Virulence factor MUTATION: irp mutant is attenuated in competitive index experiment in pig infection model (Subashchandrabose et al., 2009). 19703979
4140 pntB from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852493 165976258 APJL_0849 YP_001651851.1 pyridine nucleotide transhydrogenase Virulence factor MUTATION: pntB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4141 recR from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852506 165975531 APJL_0074 YP_001651124.1 recombination protein RecR Virulence factor MUTATION: recR mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4142 lpdA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852591 165976188 APJL_0774 YP_001651781.1 dihydrolipoamide dehydrogenase Virulence factor MUTATION: lpdA mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4143 dnaK from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852606 165977352 APJL_1953 YP_001652945.1 molecular chaperone DnaK Virulence factor MUTATION: dnaK mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4144 ilvI from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852660 165976143 APJL_0729 YP_001651736.1 acetolactate synthase 3 catalytic subunit Virulence factor MUTATION: ilvI mutant is attenuated in pigs (Subashchandrabose et al., 2009). 19703979
4145 aroA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852699 165976117 APJL_0697 YP_001651710.1 3-phosphoshikimate 1-carboxyvinyltransferase Virulence factor MUTATION: aroA mutant is attenuated in pigs (Garside et al., 2002). 12027598
4146 moaA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852711 165976108 APJL_0688 YP_001651701.1 molybdenum cofactor biosynthesis protein A Virulence factor MUTATION: moaA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4147 dnaJ from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852738 165977351 APJL_1952 YP_001652944.1 chaperone protein DnaJ Virulence factor MUTATION: dnaJ mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4148 hlyX from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852761 165976066 APJL_0646 YP_001651659.1 fumarate/nitrate reduction transcriptional regulator Virulence factor MUTATION: hlyX mutant is attenuated in pigs (Baltes et al., 2005). 16040973
4149 galU from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852767 165976061 APJL_0641 YP_001651654.1 UTP-glucose-1-phosphate uridylyltransferase Virulence factor MUTATION: galU mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4150 arcA from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852795 165975506 APJL_0049 YP_001651099.1 two-component response regulator Virulence factor MUTATION: arcA mutant is attenuated in pigs (Buettner et al., 2008). 17881160
4151 atpG from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852826 165977083 APJL_1680 YP_001652676.1 F0F1 ATP synthase subunit gamma Virulence factor MUTATION: atpG mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4152 lon from Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 3 str. JL03 5852841 165975836 APJL_0394 YP_001651429.1 ATP-dependent protease LA Virulence factor MUTATION: lon mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4172 pntB from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6395887 190150167 APP7_0898 YP_001968692.1 pyridine nucleotide transhydrogenase Virulence factor MUTATION: pntB mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4173 moaA from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6396208 190150001 APP7_0732 YP_001968526.1 molybdenum cofactor biosynthesis protein A Virulence factor MUTATION: moaA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4174 guaA from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6396394 190149906 APP7_0637 YP_001968431.1 GMP synthase Virulence factor MUTATION: guaA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4175 hemA from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6396804 190149697 APP7_0428 YP_001968222.1 glutamyl-tRNA reductase Virulence factor MUTATION: hemA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4176 dnaK from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6397101 190151264 APP7_1995 YP_001969789.1 molecular chaperone DnaK Virulence factor MUTATION: dnaK mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4177 hemE from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6397393 190149381 APP7_0112 YP_001967906.1 uroporphyrinogen decarboxylase Virulence factor MUTATION: hemE mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4178 prfC from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6397642 190149299 APP7_0030 YP_001967824.1 peptide chain release factor 3 Virulence factor MUTATION: prfC mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4179 znuA from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6397685 190150761 APP7_1492 YP_001969286.1 high-affinity zinc transporter periplasmic component Virulence factor MUTATION: znuA mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4180 recR from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6397705 190149343 APP7_0074 YP_001967868.1 recombination protein RecR Virulence factor MUTATION: recR mutant is attenuated in pigs (Sheehan et al., 2003). 12819083
4181 tig from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6397772 190150836 APP7_1567 YP_001969361.1 trigger factor Virulence factor MUTATION: tig mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4182 rpmF from Actinobacillus pleuropneumoniae serovar 7 str. AP76 Actinobacillus pleuropneumoniae serovar 7 str. AP76 6397986 190150706 APP7_1437 YP_001969231.1 50S ribosomal protein L32 Virulence factor MUTATION: rpmF mutant is attenuated in porcine model of infection (Fuller et al., 2000). 10873489
4885 LPS Actinobacillus pleuropneumoniae Virulence factor MUTATION: an isogenic LPS mutant (with a mutation in the galU gene) was attenuated in adherence and virulence in pigs (Rioux et al., 1999). 10696481
4886 capsule Actinobacillus pleuropneumoniae Virulence factor MUTATION: an acapsular cpxC mutant is avirulent in pigs (Jacques, 2004). 15188950
4939 apxIIA Actinobacillus pleuropneumoniae L20 4848738 126208432 APL_0956 CP000569 YP_001053657 RTX-II toxin determinant A Virulence factor MUTATION: A ΔapxIIA is attenuated in pigs (Boekema et al., 2004).
MUTATION: ureC/apxIIA deletion mutant is attenuated in pigs (Tonpitak et al., 2002).
15135509 12438394
4940 apxIIC Actinobacillus pleuropneumoniae L25-4 52630373 AAU84699.1 ApxIIC Virulence factor MUTATION: An insertionally inactivated apxIIC mutant is attenuated in pigs (Prideaux et al., 1999). 10085043
4941 apxIIIB Actinobacillus pleuropneumoniae serovar 2 470686 AAA21925.1 RTX toxin Virulence factor MUTATION: An apxIIIB mutant, in combination with an apxIIID mutation, is highly attenuated in pigs (Park et al., 2009). 19887737
4942 apxIIID Actinobacillus pleuropneumoniae serovar 2 470687 AAA21926.1 RTX toxin Virulence factor MUTATION: An apxIIIB mutant, in combination with an apxIIID mutation, is highly attenuated in pigs (Park et al., 2009). 19887737
4943 apxIVA Actinobacillus pleuropneumoniae 6671152 AAF23114.1 ApxIVA Virulence factor MUTATION: A precisely defined DeltaapxIICDeltaapxIVA double-deletion mutant of A. pleuropneumoniae is attenuated in pigs (Liu et al., 2007). 17767980
4944 ureC Actinobacillus pleuropneumoniae 2828543 AAC00060.1 UreC Virulence factor MUTATION: ureC/apxIIA deletion mutant is attenuated in pigs (Tonpitak et al., 2002). 12438394